Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"Often, of course, malaria exacted a toll on both sides. It pushed English Protestants into Catholic Ireland, setting the stage for the Troubles centuries later. But Oliver Cromwell, the Englishman who conquered Ireland, died of malaria, in 1658, rather than take quinine, the only known treatment, because he associated it with its Catholic discoverers, making him a victim of both parasitosis and sectarianism."
https://www.newyorker.com/magazine/2019/08/05/how-mosquitoes-changed-everything
Monoclonal targeting Plasmodium falciparum circumsporozoite protein (PfCSP)
"We conducted a phase 2 trial to assess the safety and efficacy of a single intravenous infusion of CIS43LS against P. falciparum infection in healthy adults in Mali over a 6-month malaria season"
#Plasmodium #Malaria #MonoclonalAntibody #clinicaltrial
https://www.nejm.org/doi/full/10.1056/NEJMoa2206966?query=featured_home
In depth reporting at STAT on the development of Bharat Biotech's Covaxin
"Protocols were not in public domain while the trials were happening, and the trials were happening at breakneck speed with no information about the basis for granting approvals,” said Aisola, adding that the handling of the adverse event also set a poor tone for investigating and sharing information with the public. “This isn’t just a purely scientific issue. It involves the role of the government and its partner, which was more than happy to cooperate, because it benefited as well.”
https://www.statnews.com/2022/11/15/vaccine-covid19-india-bharat-covaxin-transparency-protocols/
Thiago Carvalho
boosted
#Postdoc position to investigate cGAS-STING-dependent signaling in drosophila. A three-year postdoc position starting in spring 2023 with Jean-Luc Imler and 🐘krin_meignin@drosophila.social at IBMC in Strasbourg (France). #immunity #drosophila #virus
Thiago Carvalho
boosted
Intro post: I'm a professor of #Biology at the #UniversityOfWashington. My training is in #EvolutionaryBiology, #BehavioralEcology, #PopulationGenetics, and #Epidemiology. I did lots of work in #Bibliometrics and #NetworkTheory. I teach #DataLiteracy. These days I spend a lot of time thinking about the spread of #Misinformation, the #ScienceOfScience, and #PhilosophyOfScience. I do a lot of #BirdPhotography and love #ravens, #crows, and all #corvids.
For your trouble, here's a perfect crow.
Thiago Carvalho
boosted
Hey, y’all. My name is Chris. I’m a geoscientist, working for the engineering company Jacobs. I’m from Derby, but currently based near Manchester, on the side of the Peak District, which allows me to do two things I really like; running and cycling. When not messing fiddling with the Earth, I’m usually found discussing social justice issues with a pint. I’m the woke Black man that your granny warned you about…
Thiago Carvalho
boosted
Here the three candidate-vaccines against Ebola recently evaluated by the WHO committee of external experts.
RT @WHO@twitter.com
@DrTedros@twitter.com @g20org@twitter.com @GlobalGoalsUN@twitter.com "Today, I’m pleased to announce that a WHO committee of external experts has evaluated three #Ebola candidate vaccines and agreed that all three should be included in the planned trial in #Uganda"-@DrTedros@twitter.com http://bit.ly/3AjxdP5
Thiago Carvalho
boosted
🔬🧬 Italy's research institute for #LifeSciences based in Palazzo Italia, Milan.
👨🔬 👩🔬 Our mission is to promote human health & well-being.
#lifescience #science #genomics #neuroscience #biology #computationalbiology #structuralbiology #datascience #biostatistics #molecularbiology #microbiology #bioinformatics #cryoem #cryoet #machinelearning #openscience #scicomm #crispr #genetics #organoids #medicine #publichealth
Thiago Carvalho
boosted
How does APOE4 affect #humanbrain in #Alzheimer’s disease?
The new paper on @Nature by our Jose Davila-Velderrain, Group Leader at the #Neurogenomics Research Centre, and colleagues at the Massachusetts Institute of Technology and the #BroadInstitute of #MIT and #Harvard, led by Li-Huei Tsai, paves the way for the development of novel therapeutic strategies for AD.
#science #sciencemastodon #lifesciences #lifescience #neuroscience
https://humantechnopole.it/en/news/how-apoe4-affects-human-brain-in-alzheimers-disease/
Thiago Carvalho
boosted
Hi everyone, I’m Alessandro Nascimento, professor at University of São Paulo, Brazil.
My main interests are on structural biology, including #ProteinCrystallography, and some computational modeling, e.g., #molecularDynamics simulations, #docking, etc.
Our current research is focused on the structural determination of new antibiotic target candidates and their chemical validation. We have a special interest in enzymes involved in the synthesis and modifications of carbohydrates and we are also very interested in learning AI methods and their application in structural biology.
Thiago Carvalho
boosted
#introductions
I am a chemist and an 🧲 #NMR spectroscopist and Facility Manager at #CSIC 🇪🇸 Spanish National Research Council.
🤩 Personal interests include #MMR, #Chemistry, #StructuralBiology, #ProteinStructure, #Biophysics, #Glycotime…
I will be posting about #NMR, cool #Science and geeky things 😅 Mostly on social media to meet fellow humans, to learn and to have fun.
"Here, we show that neuronal signal-regulatory protein alpha (SIRPα) is a permissive cue for microglial #phagocytosis in the developing murine retina. Removal of neuronal, but not microglial, SIRPα reduced microglial phagocytosis, increased synpase numbers, and impaired circuit function. Conversely, prolonging neuronal SIRPα expression extended developmental microglial phagocytosis. These outcomes depended on the interaction of presynaptic SIRPα with postsynaptic CD47."
#Immunity #Immunology #Microglia #Neuroimmunology
https://www.cell.com/immunity/fulltext/S1074-7613(22)00559-3
"Acontece que este movimento é apenas mais um de um enorme esforço de apoio às empresas que o Estado português tem feito, sem evidência de que esteja a funcionar no sentido de promover ciência ou inovação e sem a esperada canalização de fundos para investigação académica."
Joana Sa on the recent (very disturbing) #SciencePolicy #ScienceFunding trends in Portugal
https://www.publico.pt/2022/11/17/opiniao/opiniao/ciencia-melhores-empresas-2027963
"A new study, based on 25 years of data from Australia, suggests that environmental changes have been driving these spillovers by radically altering the ecology of black flying foxes. Deforestation, coupled with climate-linked food shortages, has driven the bats into human-dominated habitats like farms, where food is readily available but may be of poorer quality, scientists reported in Nature on Wednesday."
Thiago Carvalho
boosted
Hi everyone, 🙂
Starting on Mastodon!
I am interested in cancer and aging. I study telomeres 🧬 in zebrafish 🐟 and what happens when they get fu€&ed up 💥 ...
Thiago Carvalho
boosted
For anyone interested in the great and terrible beauty of immunometabolism (drives immune cell fate and phenotype and disease outcome but with unpronounceable things) https://pubmed.ncbi.nlm.nih.gov/32320073/
Thiago Carvalho
boosted
ACS Chem Biol put together a special issue on #bioorthogonal and #clickchemistry, great selection of articles that touch upon every biomolecule type with far-ranging applications in biology and medicine. Well done!
https://pubs.acs.org/page/acbcct/vi/click-bioorthogonal-chemistry
Thiago Carvalho
boosted
Colleagues at our sister #journal Science Immunology are looking to #hire another #editor to join their team! Prior editorial experience is welcome but not required. #RemoteWork is an option. The #job advertisement can be found here:
bit.ly/NextSciImmEditor
Thiago Carvalho
boosted
And another job... Posting another job in our department. Tenure track Immunology. #academicjobs #biology #immunology
Please boost to help us spread the opportunity.
http://webapps.yorku.ca/academichiringviewer/viewposition.jsp?positionnumber=2368
Thiago Carvalho
boosted
RT @PradeepMadapura@twitter.com
We just released a massively revised version of the paper. Overall, we show for the first time #LINE1 with #H4K16ac function as #enhancers to rewire the regulatory landscape of the genome https://www.biorxiv.org/content/10.1101/2022.04.29.488986v2 feedback welcome! https://twitter.com/PradeepMadapura/status/1520340222382329856
🐦🔗: https://twitter.com/PradeepMadapura/status/1593132480680562688
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
