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The most recent approved gene therapy, as @STAT reports, will cost $3.5m per patient.
Editas just abandoned a gene editing program because it has <300 patients in the US.
= the challenge of affordability and health justice for CRISPR cures has never been this urgent.
statnews.com/2022/11/22/fda-ap

My #introduction

I’m a clinician scientist and ICU consultant based in Cambridge, UK. I study the immune effects of critical illness, particularly why neutrophils fail and how this leads to nosocomial infections. Through this I’ve collided with a number of research areas, including diagnostics for pneumonia, transcriptional responses to pathogens and air scrubbing- collecting eclectic interests along the way.
Active in ESICM, currently chairing the INF section.

"The mere existence of such a cell should be one of the great astonishments of the earth."

"People ought to be walking around all day, all through their waking hours calling to each other in endless wonderment, talking of nothing except that cell.”

by Lewis Thomas, from "The Medusa and the Snail"

Watch a Salamander emerge From a Single Cell youtube.com/watch?v=SEejivHRIb

#DevBio

#Introduction I am Scientist #HHU, social Media Liaison @APSbacteriology & AAAS Women in STEM community Ambassador. I love sensors, microbes, plant-pathogens among others. Concerns about inclusion & diversity in STEM and climate emergency #Biophysics#Biosensors # #plantpathology #microbes #WomenInSTEM #ClimateAction. I am now also on Mastodonte. My twitter: twitter.com/MayuriSadoine & My linkedin: linkedin.com/in/mayuri-sadoine

'We have developed OpenFold, a complete open-source reimplementation of AlphaFold2 that includes training code and data. By training OpenFold from scratch and matching the accuracy of AlphaFold2, we have demonstrated the reproducibility of the AlphaFold2 model for protein structure prediction. Furthermore, the OpenFold implementation introduces technical advances over AlphaFold2, including markedly faster prediction speed.'

biorxiv.org/content/10.1101/20

*PRO NERD TIP*

Today I learned about "The Wikipedia Library Card". If you've been a WP editor for >6 months, have made >500 edits, at least 10 edits in the last month, and are not blocked for being a cretin, you can access a *ton* of paywalled content for free.

ScienceDirect, AAAS, The BMJ, both APAs, EBSCO, Springer, Nature, Wiley, and many more.

wikipedialibrary.wmflabs.org/a

All those hours in 2005 spent editing sci-fi book articles finally paying off!

"The advent of the gene-editing technology CRISPR–Cas9 in the 2010s provided a catalyst for the field, making it easier to modify not only the gene involved in α-Gal production, but a host of others that might help human bodies to tolerate pig organs."

#glycotime

RT @Nature@twitter.com

Will pigs solve the organ crisis? The future of animal-to-human transplants go.nature.com/3EWxMRu

🐦🔗: twitter.com/Nature/status/1595

Richard Lenski (at his blog) on S.J Gould & the

"Of course, Gould’s experiment is impossible at a paleo-planetary scale. But at a more modest scale, one of the main goals of the LTEE is to study the repeatability of evolution. And so, I often quote from Wonderful Life when I’m giving talks about the experiment. Thus, it’s only natural that someone might wonder if Gould’s book had inspired me to start the LTEE."

telliamedrevisited.wordpress.c

#introduction
I’m a conservation biologist focusing on #cetaceans. I'm presently using molecular, ecological, and demographic approaches to understand the interconnectedness of bottlenose dolphins in the Iberian Peninsula region; with a particular interest in the declining resident population of Sado estuary, 🇵🇹 !!

Before, I studied cetaceans (mostly humpback whales) in 🇸🇹 (west Africa).

Other interests around here: #popgen,#POPs, #marineconservation; #MPAs; #SciComm

'At the time, Argentina’s regime, the bloodiest in modern South American history, was rounding up thousands of real and presumed leftists and putting them in torture camps or killing them outright in what came to called the “dirty war.” The dictatorship lasted seven years, during which at least 8,960 people disappeared, according to official estimates. Some human rights groups put the figure at 30,000.'

nytimes.com/2022/11/22/world/a

Two questions:

1) Does anyone have a reccomendation for a Drosophila anti-SuVar39 antibody?

2) I see this kind of questions becoming more prominent within our community so it may be a good idea to decide on hashtags to be used in the future. I can't think of anything genius right now so I'll go with silly #flyreagents or #flyrequest but feel free to propose something better!

Hello Mastodon.

I am looking for new PhD students to come work with me at the Oxford Internet Institute in 22/23 (@oiioxford) to study the future of data privacy and digital rights, the impact of AI and algorithms on digital platforms, and help co-create better digital futures.

Boosts very much appreciated! 🐘

Super proud of my brother Yoav, check out his beautiful paper and spread the word! 💥🥳🎓 Does exercise change coding in the brain?

check out the paper and also his

cell.com/cell-reports/fulltext/S2211-1247(22)01569-8

twitter thread:
twitter.com/yoavrec/status/159

RT @GRC_CMM
Hey #cilia & #centriole tweeps- we are just under two weeks from our deadline ⏳December 5th⏳ for abstracts for talk slots at 2023 GRC Cilia, Mucus and Mucociliary meeting in Barga, Italy! #RareDisease #Therapeutics #Biophysics #Biofilms #Mucus #CF #PCD grc.org/cilia-mucus-and-mucoci

Orbanization 

"Viktor Orbán, has worn a football scarf showing Hungary’s pre-world war one borders, which included parts of Ukraine and Romania among others. " - I am sure he meant nothing by it, colonialism must be the last thing on his mind 😒

Ongoing rumination: how easy is it for evolution to uncouple gametogenesis from meiosis I…. Pretty easily, I would imagine… check out how common parthenogenesis is…. therefore can we potentially generate a parthenogenic drosophila?

Hi #ScienceMastodon, time for an #introduction!

I'm an #EvoDevo biologist interested in how tissue #mechanics influences the #evolution of #morphogenesis. I study a deep and mysterious epithelial invagination that forms at the head-trunk boundary of #flies during #gastrulation, known as the #CephalicFurrow (see video below!). Currently, based in Germany as a postdoc in the Tomancak Lab at MPI-CBG. Looking forward to meeting you!

#DevBio #mechanobiology #microscopy #lightsheet #embryos

RT @ResFortnight
Seventy more UK ERC winners face tough choice to stay or go: European Research Council announces 408 winners of 2022 Starting Grants—posing dilemma for UK-based researchers. (£) @ResearchEurope @ERC_Research

researchprofessionalnews.com/r

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