Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'As of yet, none of the improved IL-2-based compounds gained regulatory approval for the treatment of cancer or autoimmune diseases. Three compounds treating cancer have entered phase 3 trials with two studies still ongoing. NKTR-214 is the only compound that has completed phase 3 studies.'
#Immunology #Immunotherapy #IL2 #Preprint
https://www.medrxiv.org/content/10.1101/2022.12.02.22283042v1
Thiago Carvalho
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If anyone here interested in further deconvoluting cytokine biology and activity from single cell RNA -Seq data, this looks intriguing... (and promising)
#immunology #sequencing #transcriptomics #singlecell #RNAseq
https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btac775/6865029
Thiago Carvalho
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The amazing @Moatazassem has arrived on Mastodon!
Moataz does super cool work on task-active #brain regions using #fMRI and #ECoG, especially high-res HCP methods. Moataz also has a new #preprint out on the basis of executive functions in fine-grained architecture of cortical and subcortical human brain networks:
https://www.biorxiv.org/content/10.1101/2022.12.01.518720v1
'The last-known Tasmanian tiger died in Hobart’s Beaumaris zoo on the night of 7 September 1936.
“For years, many museum curators and researchers searched for its remains without success,” Dr Robert Paddle, a researcher said.
“No thylacine material dating from 1936 had been recorded in the zoological collection, and so it was assumed its body had been discarded.”
But recent inquiries by Dr Paddle and TMAG curator of vertebrate zoology, Dr Kathryn Medlock, revealed the last-known thylacine’s remains were at the museum.'
Thiago Carvalho
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Newly observed resistance:
Group A Streptococcus found a way to harvest folate from humans, bypassing the inhibitory role of sulfamethoxazole. Hence they are only resistant to the antibiotics when they're causing an actual infection inside our bodies. https://www.sciencealert.com/scientists-just-caught-bacteria-using-a-never-before-seen-trick-to-avoid-antibiotics
'In terms of GDP per capita, it is the EU’s fifth-richest member state. Natural gas accounts for only 2% of its energy, insulating it from the worst economic ravages of Russia’s war on Ukraine. Poverty is far below the European average.
But fast-rising electricity bills and surging food price inflation are taking their toll here as elsewhere. “Sweden also has a poverty problem,” said Johan Rindevall. “We may not talk about it much, but it’s there – and it’s absolutely got worse this year.”
Thiago Carvalho
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Apply to this cool DFG-funded post doc position with @MarthaMerrow at LMU Munich 🇩🇪 on Bacillus subtilis circadian rhythm systems biology if you have experience with microbial transcriptome/proteome👇
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RT @MarthaMerrow
We’re hiring a Post-doc with microbiology and systems biology experience to work on the B. subtilis circadian clock. Super collaboration with @EvolvedBiofilm and @ant_dodd. Apply by 31 Dec. See here for description: h…
https://twitter.com/MarthaMerrow/status/1598742011724664859
Thiago Carvalho
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We're delighted to be at #CellBio2022 this week. Visit booth #1825 to say hello and to learn more about our initiatives
Thiago Carvalho
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#Advent Day5: Another close relative of obscura, #Drosophila subsilvestris was originally described as ‘silvestris’ in 1954 by EB Basden (who hadn’t read his literature) using flies from near Edinburgh http://www.drosophila.jp/jdd/class/030701/03070107.pdf . Dsus is similar to Dobs & Dtri in looks and known ecology, and is common in Scotland—but is harder to keep in the lab. Dsus is our least-studied species so far, with just 12 papers in WOS and its only apparent claim to fame being some B chromosomes https://link.springer.com/article/10.1007/BF00355318
Thiago Carvalho
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Philippe Ganot et al. present an alternative and straightforward method for extracting skeletal organic matrix from a red coral that requires little equipment and saves steps:
journals.biologists.com/bio/article/11/10/bio059536/277219
Thiago Carvalho
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Mastodon growth numbers might not mean what you think they mean...
In which I unpack the data sources & explain what's misleading about that 8 million data point.
#MastodonStats #MastodonMigration #TwitterMigration
Thiago Carvalho
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@Mill_lab @clathrin Had to look "bah humbug" up, and, amusingly, there's this:
Ba humbugi, a species of land #snail https://en.wikipedia.org/wiki/Ba_humbugi
...which seems apt, and not a coincidence:
"Alan Solem chose the generic name Ba after Ba District, Fiji, which extends into B. humbugi's range. This led to him having an "irresistible impulse" to name the type species Ba humbugi, in reference to the character Ebenezer Scrooge's catchphrase "Bah! Humbug!" from Charles Dickens's novella A Christmas Carol."
Thiago Carvalho
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Our paper on "The Impact of Genetic Surfing on Neutral Genomic Diversity" is out in MBE
https://doi.org/10.1093/molbev/msac249
with @StephanPeischl and, above all, Flavia Schlichta!
Thiago Carvalho
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New pre-print by Sarah Walsh (🥇 from her PhD) looking at the (broad) host range of a phage across 64 Staphylococcus isolates - incl 17 species. Sarah found the host phylogeny is an important determinant of infectivity and susceptibility across this panel of hosts https://doi.org/10.1101/2022.11.30.518513 Fun collaborative project on this neat tractable system set up together with Angus Buckling. Big thanks to other coauthors too for all of their help!
Thiago Carvalho
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The @EMBOPress #editor roadshow is making a stop in Washington DC for the ASCB | EMBO #CellBio conference. If you're attending the meeting, visit us at booth #1433 to discuss #publishing your latest research! @embojournal @MolSystBiol @EmboMolMed @ReviewCommons
"A close examination of the IL-2–IL-2Rα binding interface reveals a putative “pH Switch” consisting of the interaction between Arg38 in IL-2 and His120 in IL-2Rα (Fig. 2F). We hypothesized that, at the low pH in the TME, His120 would become protonated, resulting in release of IL-2 from IL-2Rα and therefore lack of signaling."
"These findings demonstrate that despite extremely close genetic relationships between T. pallidum genomes globally, genomics can still be used to identify putative transmission clusters for epidemiological follow-up, and therefore has a role to play in informing public health interventions"
#PublicHealth #Epidemiology #Preprint #STD #Syphilis
https://www.medrxiv.org/content/10.1101/2022.12.02.22283031v1
Thiago Carvalho
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Hi! 👋🏻 I am the coordinator for the Open Science Center at the LMU University in Munich. We promote open research practices through peer to peer training, community building, and liaising with stakeholders to reform incentives and policy.
I am a former biologist and cofounded the Society for Open Reliable and Transparent Ecology and Evolutionary biology, SORTEE.
I only post about #OpenScience, but I'm also #French #FirstGen #ClimateAnxious #Vegan #Autistic #LGBTQIA+
Thiago Carvalho
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🚨 A new study finds that "#LongCovid is associated with new-onset insulin resistance (IR) in a subset of patients. Increased IR may contribute to the onset of depressive symptoms due to #LongCovid by enhancing overall neurotoxicity." http://medrxiv.org/cgi/content/short/2022.12.01.22283011v1
Thiago Carvalho
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RT @DagmarIber
RT @yoginho
RT EMBOevents
Sign up now! Registration and abstract submission is now open until 31 March for EMBO Lecture Course on Venice Summer School: The future of evolutionary-developmental systems biology, 21 – 25 August 2023 in Venice, Italy (1/2)
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
