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A team led by #mdcBerlin's @ash_d_sanders in collaboration with scientists from @embl has developed a method that could pave the way for personalized #CancerTreatments – using #SingleCell data and #AI, the researchers report in @NatureBiotech: mdc-berlin.de/news/news/ai-ana

Estimation of activity changes for >500 kinases & transcription factors in >1,000 cancer samples & cell lines identifies drivers of signalling dysregulation & patient survival ➡️ bit.ly/3Jb9l5b
@pedrobeltrao IMSB ETH
@saezlab UniHeidelberg
@Epetsalaki EMBL-EBI
#CancerGenomics #Genomics #Phosphoproteomics #SystemsBiology

'Sometimes the collapse of the #NHS looks like a patient being declared dead on an A&E waiting room floor. But sometimes it looks like a young woman crying on her sofa in pain'!

as the primary care for my wife who has Functional Neurological Disorder, but remains relatively healthy, we've been on the edge of these problems but recognise much of the plight of those with more debilitating ongoing conditions!

But this is not an accident; it has been wrought by the #Tories!
theguardian.com/commentisfree/

“This was an era when the Harris Poll reported that 63% of Americans considered homosexuals “harmful” to society, and the official manual of the American Psychiatric Association stated that all homosexuals were mentally ill.”

theguardian.com/books/2023/jan

Yapici lab 🖨️🔥 off the press!!
The story of novel visual feedback neurons make sure that males flies court nice n’ steady 😎

Kudos to the awe-inspiring twitterless first-author Yuta, and Nilay (also twitterless now!) & to @XinyueCui , @HaeinKim6🎉🎉

biorxiv.org/content/10.1101/20

'Takei, just five years old at the time, was one of 120,000 Japanese Americans interned by the US government following the Pearl Harbor attack: an egregious violation of their rights. The deprivation and humiliation of this experience form the texture of the musical, which follows fictitious families thrown together in the “relocation centre” at Heart Mountain, a dismal, sand-blown cluster of huts in Wyoming.'

ft.com/content/4d4189c5-a533-4

NEW ARTICLE: Seven Films Directed by Alfred Hitchcock Free on YouTube

In this new article, I share seven Hitchcock films available for you to watch for free and study on YouTube, including one of his undisputed masterpieces — REBECCA. This is an excellent way to improve your understanding of cinema, storytelling (especially suspense), and general filmic craft.

Read: medium.com/@cole.haddon/seven-

#film #movies #cinema #filmmaking #screenwriting #writing #writingcommunity #AlfredHitchcock #directing

The MICrONS program was a hugely ambitious effort to map the connectivity patterns of 1 mm3 of mouse cortex and their relationships to brain function. I know that it led to some tremendous technical advances in automated electron microscopy and processing of that data. It also led to a connectivity map for 200K neurons and 500 million synapses.

technologyreview.com/2017/10/1

What I understand less about is whether the new concepts and findings that emerged from the project.
@neurobongo, @xaq, (anyone): What is the status there? (Note this Q is not a criticism - if it's all still tech and maps thus far, that's still a really important step).

Fascinating study examining the switch from coexistence to pathogenicity in a marine association

Bacterial lifestyle switch in response to algal metabolites

elifesciences.org/articles/844

#microbiology #marine #symbiosis

🧠🧠Latest #coverart 🧠🧠

It's for an #openaccess textbook on biological #psychology published by the University of Sussex.

Now... can you work out what on earth I was going for here? 😂

#sciart #MastoArt #ScienceMastodon

'But the descent of Britain is in many ways more dramatic. By the end of next year, the average British family will be less well off than the average Slovenian one, according to a recent analysis by John Burn-Murdoch at The Financial Times; by the end of this decade, the average British family will have a lower standard of living than the average Polish one.'

nytimes.com/2023/01/25/opinion

'Crystal Mackall remembers her scepticism the first time she heard a talk about a way to engineer T cells to recognize and kill cancer. Sitting in the audience at a 1996 meeting in Germany, the paediatric oncologist turned to the person next to her and said: “No way. That’s too crazy.”

nature.com/articles/d41586-023

RT @RepRashida
Palestinians may be banned from flying their flag under an apartheid government, but we can still proudly do it at my office. I’m proud to be a Palestinian American and I want the Palestinian people to know that not all Americans support apartheid. No one can erase our existence.

pnas.org/doi/10.1073/pnas.2217

I wanted to highlight this exciting new class of mouse models for HIV vaccine research from Frederick Alt's lab, recently published @PNASNews

Several of our postdocs and senior research staff contributed to this work. This level of lymphocyte diversity represents an important step for preclinical evaluation!

My latest clinical pipeline column for @NatureMedicine is out today.
It's a look at the recent approval of mosunetuzumab, 's bispecific anti CD20/CD3 monoclonal antibody
for relapsed or refractory follicular .

nature.com/articles/d41591-023

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