Thiago Carvalho @cyrilpedia@social.cleverlibre.org

“Declaring the public-health emergency over would give governments and some public-health agencies permission to look away and move on to other things,” says Mark Woolhouse, an epidemiologist at the University of Edinburgh, UK. “It remains a very significant public-health problem. About a quarter of the world is still unvaccinated, and that’s potentially a lot of vulnerable people.”

#COVID #COVID19 #PublicHealth

https://www.nature.com/articles/d41586-023-00294-9

"Here, we have developed a robust computational framework to determine the prognostic strengths of a variety of molecular features relative to conventionally utilized clinical factors such as tumor stage, age, and histopathology across a vast compendia of cancer cohorts from TCGA."

#Genomics #PrecisionMedicine

https://www.cell.com/cell-genomics/fulltext/S2666-979X(23)00018-6

At the Human Technopole Institute, Milan.

'As global demand for Covid-19 vaccines dries up, the program responsible for vaccinating the world’s poor has been urgently negotiating to try to get out of its deals with pharmaceutical companies for shots it no longer needs.

Drug companies have so far declined to refund $1.4 billion in advance payments for now-canceled doses, according to confidential documents obtained by The New York Times.'

#COVID #COVID19 "
#SARSCoV2 #PublicHealth

https://www.nytimes.com/2023/02/01/health/covid-vaccines-covax-gavi-prepayments.html?action=click&module=Well&pgtype=Homepage&section=Health

'Munch was a different musician under studio conditions than he was live, Holoman writes, and he controlled his most explosive tendencies in the hope of making records that would last. Even his two incendiary Boston readings of Berlioz’s “Symphonie Fantastique,” his trademark piece, come nowhere close to the maelstrom he inflamed onstage.'

https://www.nytimes.com/2023/02/02/arts/music/charles-munch-conductor.html

By the time they're done with it, is it still your manuscript?

"To characterize cell-type-specific transcriptional heterogeneity in active Crohn’s disease, we profiled 720,633 cells from the terminal ileum and colon of 71 donors with varying inflammation status."

#Immunology #MucosalImmunology #crohnsdisease

https://www.cell.com/immunity/fulltext/S1074-7613(23)00012-2

Birthday party in Milan.

Ciao Milano

"Here, among seemingly unending geological strata, we can gaze into what the natural philosopher John Playfair called ‘the abyss of time’, a description he made after he, James Hall and James Hutton in 1788 observed layered geological aeons in the rocky outcrops of Scotland’s Siccar Point – a revelation that would eventually lead Hutton to become the founder of modern geology. In the Rift Valley, this vertical, tilted way of seeing is all the more powerful because the story of the Rift is the story of all of us, our past, our present, and our future."

https://aeon.co/essays/the-rift-valley-tells-the-entire-human-story-from-the-start

"The current model for GVHD holds that disease is maintained through the continued recruitment of alloreactive effectors from blood into affected tissues. Here, we show, using multiple approaches including parabiosis of mice with GVHD, that GVHD is instead primarily maintained locally within diseased tissues."

#Immunology #GraftVersusHost

Sacirbegovic et al @ImmunityCP https://www.cell.com/immunity/fulltext/S1074-7613(23)00013-4