Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Research Assistant in Leukemia

Join the lab to work on the metabolism of T-ALL in Montreal!

https://jobrxiv.org/job/sainte-justine-research-center-27778-research-assistant-in-leukemia/?feed_id=39402

#ScienceJobs #job #leukemia #metabolism
Montreal #Canada #ResearchAssistant
https://jobrxiv.org/job/sainte-justine-research-center-27778-research-assistant-in-leukemia/?feed_id=39402

Interesting piece in Nature about the type 1 #diabetes drug Teplizumab, the first that the FDA has ever approved to delay the onset of the disease:

https://www.nature.com/articles/d41586-023-00400-x?utm_source=linkedin&utm_medium=social&utm_content=organic&utm_campaign=CONR_JRNLS_AWA1_GL_SCON_SMEDA_NATUREPORTFOLIO#ref-CR11

I wrote about the drug in mid December for #NatureMedicine

https://www.nature.com/articles/d41591-022-00115-y

A worthy gawp:
Accelerating crystal structure determination with iterative AlphaFold prediction

#crystallography #structuralBiology
#Alphafold @strucbio
http://journals.iucr.org/d/services/forthcoming.html#nz5011

"Here we report a murine model that expresses tumor-like levels of human APOBEC3B after Cre-mediated recombination. Animals appear to develop normally with full-body expression of APOBEC3B. However, adult males manifest infertility and older animals of both sexes show accelerated rates of tumorigenesis (mostly lymphomas or hepatocellular carcinomas)"

https://www.biorxiv.org/content/10.1101/2023.02.24.529970v1

Does accumulation of #macromolecules in the highly protein-rich #mitochondrial matrix regulate solute diffusion and biochemical reactions?
Using FRAP analysis of #organelle-targeted fusion peptides, Werner Koopman and colleagues report macromolecular crowding as a stress-dependent determinant of matrix mobility and viscosity

https://www.embopress.org/doi/10.15252/embj.2021108533

@Nature Oral Azvudine (FNC) Tablets in Patients infected with #SarsCoV2 #omicron Variant: Azvudine is a thymus-homing anti#SarsCoV2 drug effective in treating #COVID19 patients
📌https://www.medrxiv.org/content/10.1101/2023.01.05.23284180v1.full.pdf
📌https://www.nature.com/articles/s41392-021-00835-6

I love the point where science meets art.

What you see are cells of the eye that are important for neuron function and health. In the bottom half, where you see all the protrusions, is where the cells and neurons collide. #LoveScience

#sciArt #science #imageAnalysis #Data

01/2023 Issue ➡️ http://bit.ly/3CMpyKi
On the cover: Engineered bacteria expressing a designed single-chain IL-10 prevent severe inflammation in Pseudomonas aeruginosa lung infection
Luis Serrano lab, CRG
#proteinengineering #immunomodulation #synbio #SystemsBiology

My thoughts on the Met’s new Lohengrin:

https://bachtrack.com/review-lohengrin-girard-beczala-wilson-nezet-seguin-metropolitan-opera-february-2023

Intro: I'm a #Biology professor researching the #Neurogenetics of #learning and #memory in #Drosophila. I study how operant or motor memories are formed and how other forms of learning regulate these processes. As spontaneous behavior is required for operant learning, I also study how #spontaneity arises in nervous systems.

Our lab practices #openscience

Disclaimer: Since I got tenure in 2012, my non-tenured co-authors decide where our manuscripts are submitted.

Thinking about the NYT (and other) pieces about the collapse of both time and world view in pandemic, and pieces in Atlantic (and elsewhere) about the collapse of time and post #ww2 worldview in the accumulating/ staggering local and global crises. These are such deeply related phenomena. Braudel had some things very right in terms of how we think about human history and what matters and when. #history #DeepTime #Braudel #histodons

"Several of the world’s biggest pharmaceutical companies are fighting shareholder proposals to force them to disclose information on their use of a controversial patent strategy that can delay rivals from launching cheaper versions of blockbuster drugs.

A coalition of ethical investors have asked Johnson & Johnson, Merck, Pfizer, Eli Lilly, Gilead, Amgen, Regeneron, Bristol Myers Squibb and AbbVie to publish a report on the process they follow when applying for multiple patents on a single drug."

https://www.ft.com/content/c5498e67-a48f-4adc-b85f-7bf1a0d400f6

Fasted bones grow fast later: chondroprogenitors in the growth plate of murine long bones adapt to dietary restriction, leading to catch-up growth during refeeding. 🦴

Members of the #RoselloDiez Lab #MonashUni highlight a #preprint from Motomi Iwamoto-Enomoto and team #UofMaryland.

Another excellent addition to the preList celebrating #preLights5thBirthday.

📜 https://prelights.biologists.com/highlights/nutrient-regulated-dynamics-of-chondroprogenitors-in-the-postnatal-murine-growth-plate/

In the most recent episode we caught up with @PSarkies from University of Oxford Biochemistry to talk about his work on #Transgenerational Inheritance of #Epimutations. #chromatin #epigenetics #podcast @epigenetics

Listen here:

https://activemotif.com/podcasts#peter-sarkies