Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Haruki Murakami on originality in art & literature (from "Novelist as a Vocation".

#books #writers #bookshelf #literature

With a beautiful view of the Canals

'Yet it is still early days for AI drug discovery. There are a lot of AI companies making claims they can’t back up, says Prakash: “If somebody tells you they can perfectly predict which drug molecule can get through the gut or not get broken up by the liver, things like that, they probably also have land to sell you on Mars.”

https://www.technologyreview.com/2023/02/15/1067904/ai-automation-drug-development/?utm_campaign=site_visitor.unpaid.engagement&utm_medium=tr_social&utm_source=LinkedIn

'But the most productive plasma centres are clustered along the southern border, where Mexican citizens cross over to sell plasma in the US. “Our political leaders like Trump don’t want them in the United States but we have been allowing people to cross over to mine their bodies for blood plasma, so what does that say about us?”

https://www.theguardian.com/books/2023/mar/02/blood-money-book-kathleen-mclaughlin

“Es una radiografía de la impotencia y de la falta de voluntad. Unos obispos que cooperan, otros que no, la Iglesia parece que sí quiere, pero no quiere, creo que es todo una gran mentira. Desde el primer momento esta auditoría me pareció una pamema."

https://elpais.com/sociedad/2023-03-02/las-victimas-desencantadas-con-el-giro-de-la-auditoria-de-la-iglesia-de-los-abusos-es-todo-una-gran-mentira.html

“The critical technology tracker shows that, for some technologies, all of the world’s top 10 leading research institutions are based in China and are collectively generating nine times more high-impact research papers than the second-ranked country (most often the US).”
https://www.theguardian.com/world/2023/mar/02/china-leading-us-in-technology-race-in-all-but-a-few-fields-thinktank-finds

"Researchers who hold at least three grants from the National Institutes of Health (NIH) make up a growing portion of its grantees, according to a new study. White men predominate among these “super” principal investigators (PIs), with women and Black researchers much less likely to be part of this elite group."

https://www.science.org/content/article/women-black-researchers-less-likely-hold-multiple-nih-grants

FDA panel votes on Pfizer and GSK RSV vaccines

"On Tuesday, the panel voted in favor of the Pfizer vaccine by 7 to 4, with one abstention, on its safety and efficacy. On Wednesday, it voted 10 to 2 in favor of the GSK vaccine’s safety and unanimously on the shot’s efficacy."

https://www.nytimes.com/2023/03/01/health/rsv-vaccine-fda.html?action=click&module=Well&pgtype=Homepage&section=Health

Preclinical study of anti-IL8 in endometriosis:

"We created a long-acting recycling antibody against IL-8 (AMY109) and evaluated its clinical potency. Because rodents do not produce IL-8 and do not experience menstruation, we analyzed the lesions in cynomolgus monkeys that spontaneously developed endometriosis and in a surgically induced endometriosis monkey model."
#Immunology #monoclonalantibodies #Endometriosis #inflammation

https://www.science.org/doi/10.1126/scitranslmed.abq5858

'Apart from trans-acting protein factors, recent evidence points to a role of different RNA species in targeting repressive histone marks and DNA methylation to these sites in mammals. Here, we review recent discoveries on this topic and predominantly focus on the role of RNA methylation, piRNAs, and other localized satellite RNAs.'

https://www.embopress.org/doi/full/10.15252/embj.2022111717