Thiago Carvalho @cyrilpedia@social.cleverlibre.org

"It might seem that the obvious course is not to make multiple models but rather to grow a network. Instead of developing two networks for recognizing cats and horses respectively, for instance, it might appear easier to teach the cat-savvy network to also recognize horses. This approach, however, forces AI designers to confront one of the main issues in lifelong learning, a phenomenon known as catastrophic forgetting. A network trained to recognize cats will develop a set of weights across its artificial neurons that are specific to that task. If it is then asked to start identifying horses, it will start readjusting the weights to make it more accurate for horses. The model will no longer contain the right weights for cats, causing it to essentially forget what a cat looks like. “The memory is in the weights. When you train it with new information, you write on the same weights,” says Siegelmann"

https://www.nature.com/articles/d41586-022-01962-y

Currently listening to: Tokyo funk sessions 2022

https://www.youtube.com/watch?v=nQufZEijRmc

"Our data provide a model where the global shutdown of protein synthesis and subsequent rebooting mediated by miR-10b-5p downregulation is a hallmark of the dedifferentiation stage of limb regeneration."

https://www.cell.com/developmental-cell/fulltext/S1534-5807(23)00049-7?rss=yes&utm_source=dlvr.it&utm_medium=twitter

Margaret Atwood's epiphany (fm her book On Writers and Writing).

Phage for lunch

"Highly purified T4 phages were rapidly internalized by mammalian cells and accumulated within macropinosomes but did not activate the inflammatory DNA response TLR9 or cGAS-STING pathways."
#Preprint #Phage

https://www.biorxiv.org/content/10.1101/2023.03.10.532157v1

"Perhaps this is as it should be: if Rupert Murdoch’s Wall Street Journal were going to embrace Free Market’s message enthusiastically, Soll would have had no reason to write the book."

https://lareviewofbooks.org/article/how-we-learned-to-love-free-markets/

Drug development sets its sights on ADAR

'RNA editing is rapidly gaining prominence as its transient and reversible changes promise a safer and more flexible option to reverse disease-causing mutations than DNA editing.'

https://www.nature.com/articles/s41587-023-01709-8

“I couldn’t say that this specific pattern of binding, or this specific expression of genes, is a causal determinant in the patient’s response to immunotherapy,” he explains.

Bhattacharya was stymied by the age-old dictum that correlation does not equal causation — a fundamental stumbling block in artificial intelligence (AI).'

https://www.nature.com/articles/d41586-023-00577-1?utm_source=linkedin&utm_medium=social&utm_content=organic&utm_campaign=CONR_JRNLS_AWA1_GL_SCON_SMEDA_NATUREPORTFOLIO

"The cheap servant

It is against the law for black servants to live under the same roof as their employers. In a private home, servants would have a separate little room in the backyard. She lives on the edge of opulence, while her own world is bare. Newspapers are her carpet, fruit crates her chairs and table."

fm 'Ernest Cole’s photographs of 1960s South Africa during apartheid' in the FT

https://www.ft.com/content/9919a741-9115-460c-b541-405b1ef2ab32

"Our model is based on experimental measurements of neuronal and muscle activity and assumes gap junctional coupling among muscle cells and calcium-dependent force generation by muscles. With these assumptions, we can robustly reproduce a basic set of Hydra’s behaviors."

https://www.pnas.org/doi/10.1073/pnas.2210439120