Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Nicola L. Stevenson et al. complete a future leader #review of the well-studied interactions between the #Golgi, #cilium and #extra cellular matrix, with a particular focus on how the interplay between all three compartments underpins healthy tissue.
https://journals.biologists.com/bio/article/12/2/bio059719/287059/The-factory-the-antenna-and-the-scaffold-the-three#Biology
#Science #BiologyOpen #AcademicMastodon
Thiago Carvalho
boosted
75% of scientists are burned out and pulling back on conferences, peer review, committee membership, etc https://www.nature.com/articles/d41586-023-00633-w
When scientists set boundaries, it not only improves their own personal well-being, but also creates norms that limits are acceptable and healthy
Thiago Carvalho
boosted
Study shows that morphogens in #Drosophila blastoderm control formation of cell densities along the #DVaxis that in turn is necessary for fine-tuning #morphogen gradient levels; #frazzled & #GUKholder are key effectors in this process #PLOSBiology https://plos.io/3YKufMO
'A big reason people don’t stay in public health is money. Salaries are small. Bureaucracies are large. Since the pandemic, abuse has also been on the rise. And in more than half the states, lawmakers have curtailed public health experts’ ability to make and carry out policies. Castrucci said that’s like using a jackhammer to shatter our own collective safety.'
'Here, Thacker et al. demonstrated that Socs3highCD11b–CD27– immature NK cells were present in samples from patients with triple negative breast cancer (TNBC) and correlated with worse prognosis. The authors further showed that this population of NK cells promoted, rather than inhibited, tumor progression in mice.'
#BreastCancer #NaturalKillerCells #NKcells
https://www.science.org/doi/10.1126/scitranslmed.abl4414#sec-2
'Unequal access to Covid-19 vaccines in 2021 led to one preventable death every 24 seconds, according to an open letter signed by prominent political figures, activists and academics that marks the third anniversary since the World Health Organization first described the coronavirus outbreak as a pandemic.'
#Covid19 #covıd #publichealth #Vaccines
https://www.ft.com/content/fcddc944-5112-4e32-be22-6ead2bc06cc7
Interview (in Portuguese) with my friend @joanagsa
on equality, implicit bias, and the pernicious myth of meritocracy in academia.
"No entanto, é raro encontrar o mesmo nível de escrutínio ou de julgamento quando gerações de homens brancos promovem outros homens brancos porque são da mesma família ou porque os pais eram amigos de infância. Porque nos lembramos mais de uns casos do que de outros, o nosso cérebro constrói uma narrativa que se perpetua."
'For example, without DeepMind the UK’s share of the citations amongst the top 100 recent AI papers drops from 7.84% to just 1.86%'
https://jameswphillips.substack.com/p/s-and-t-is-the-uk-a-world-leader
Thiago Carvalho
boosted
Fixed-term contracts harm research quality
Rahal et al. (2023). Quality research needs good working conditions. https://doi.org/10.1038/s41562-022-01508-2
Thiago Carvalho
boosted
We (the University of Sheffield) are looking for a Head of Research Software Engineering https://www.jobs.ac.uk/job/CYD056/head-of-research-software-engineering-rse.
It's a amazing role are the intersection of research and software. There's loads of emphasis on improving software practice across UoS as well as providing direct support for research projects.
Thiago Carvalho
boosted
'Here we leveraged an atlas of publicly available RNA-sequencing data of over 500,000 single cells from 15 individuals with AML and tissue from 9 healthy individuals for prediction of target antigens that are expressed on malignant cells but lacking on healthy cells, including T cells.'
'When I first saw the photograph, I didn’t recognize it as an Adams. Josie R. Johnson, a curatorial fellow at the Cantor Center for the Visual Arts at Stanford University, in Stanford, Calif., where I teach, planned to include it in an exhibition. She’d chosen the image for its otherworldly qualities. “It sticks with you,” she said, “for being such an enigma.”
https://www.nytimes.com/2023/03/13/travel/ansel-adams-photograph-sierra-nevada.html
Thiago Carvalho
boosted
Another illustration by Madalena Parreira for the online content I created while at JEM - Dan Davis.
At the time, Davis had just published The Compatibility Gene - the lottery motif alludes to matching MHC types for transplantation. A common theme for this interview and the interview with Matt Cobb (https://flexnersuitcase.wordpress.com/2015/08/17/the-first-five-pages-a-conversation-with-matthew-cobb/) was how scientists find a publisher when they have a book project
https://flexnersuitcase.wordpress.com/2015/09/14/finding-stories-a-conversation-with-dan-davis/
Thiago Carvalho
boosted
Pauls Nurse's full report on the "UK’s Research, Development and Innovation Organisational Landscape" is now published.
A very interesting read with a lot of depth in some places.
My favourite line so far ......
"It is important to recognise that high quality research is difficult to carry out and requires researchers to have the time to think."
Thiago Carvalho
boosted
Drug development sets its sights on ADAR
'RNA editing is rapidly gaining prominence as its transient and reversible changes promise a safer and more flexible option to reverse disease-causing mutations than DNA editing.'
Thiago Carvalho
boosted
"Our data provide a model where the global shutdown of protein synthesis and subsequent rebooting mediated by miR-10b-5p downregulation is a hallmark of the dedifferentiation stage of limb regeneration."
Thiago Carvalho
boosted
A conversation I had with @marcellaflamme from @PLOS about #preprints, #peerreview, AI, and, of course, #ReviewCommons has just been posted on the RC site.
"Q As we ask peer review to do more and more things, should we also be looking at new ways to recognize the work of reviewers?
LaFlamme: Another way to ask that question is: should outputs other than published articles and big grants count toward research assessment and the development of scientific careers?"
Thiago Carvalho
boosted
PI call at Institut de Génomique Fonctionnelle de Lyon (IGFL)
'We have an opening for an independent group leader (junior or established). Talented scientists leading research falling within the scientific scope of the Institute are encouraged to apply. We are seeking to increase the number of women team leaders and will particularly welcome applications from women scientists.'
Proximity-inducing drugs
“I don’t begrudge any industry scepticism,” adds Crews, who knows how long it took industry to take PROTACs seriously. “The onus is on us to demonstrate the utility of the creative fruits of our labours. We may not fully, at this point, appreciate what those opportunities are, but that shouldn’t stop us from being creative.”
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
