Thiago Carvalho @cyrilpedia@social.cleverlibre.org

'UK curator, gallerist and video essayist James Payne details how a combination of geopolitical and personal struggles led Goya to the bleak outlook that birthed these intense and often disturbing images, as well as the indelible influence they’ve had on art in the centuries since his death.'

https://aeon.co/videos/tracing-goyas-dark-journey-from-spanish-court-painter-to-macabre-visionary

T2 Phage by Madalena Parreira, a drawing for a piece I did on the Hershey-Chase experiments when I was at J Exp Med (for the short-lived JEM blog).

https://madalenaparreira.com

'Tessa wants to share her research to inspire other scientists whose burning scientific questions in new model organisms also require technological developments to answer them. To that end, she created Cuttlebase, a website that chronicles the scientific tools her team has developed, including a 3D brain atlas and a staging series of dwarf cuttlefish embryonic development.'

https://thenode.biologists.com/if-you-give-a-scientist-a-cuttlefish/research/

STING maintains cells with metastatic potential in a dormant state in a mouse LUAD model.
#Immunology #TumorImmunology #CancerImmunity

https://www.nature.com/articles/s41586-023-05880-5

"Thus, we performed a comprehensive screen of TE-chimeric transcripts across 10,357 tumors, 675 cancer cell lines and 11,686 Genotype-Tissue Expression (GTEx) adult tissues, and evaluated these TE-chimeric candidates for tumor specificity, antigenic potential, proteomic validation, HLA presentation and membrane presence."
#TumorImmunology #immunology

https://www.nature.com/articles/s41588-023-01349-3

"These differences in expression necessarily limit the usefulness of these systems in identifying and understanding the more subtle roles played by ACE2 in the development and resolution of COVID-19. To overcome these limitations, we have developed two mouse lines in which the ACE2 locus has been humanized by syntenic replacement."

#SARSCoV2
#Covid19

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011168

'It is hoped that a spatially resolved picture of protein expression, posttranslational protein modifications, cell phenotypes, and communities of cell phenotypes will not only advance our understanding of tumor evolution (3) but also guide patient treatment response prediction modeling and the development of novel cancer therapeutics targeting the TME, such as bispecific T-cell engagers, immune-checkpoint inhibitors (ICI), and chimeric antigen receptor (CAR) T cells.'

https://aacrjournals.org/cancerdiscovery/article/13/4/824/725006/Moving-Spatially-Resolved-Multiplexed-Protein

"Two concurrent outbreaks of the Marburg virus, a close cousin of Ebola that can kill as many as 90 percent of the people it infects, are raising critical questions about the behavior of this mysterious bat-borne pathogen and global efforts to prepare for potential pandemics."

#Marburg #Outbreak #publichealth #virology

https://www.nytimes.com/2023/04/03/health/marburg-outbreak-vaccine-treatment.html

Nobelist Martin Chalfie on how *not* to apply for a postdoc:

"They say 'Here is my CV and I'd really like to work in your lab, do you have any space? That's a letter that could be sent out to a hundred people, or a thousand people. There's nothing in it."

https://www.youtube.com/watch?v=x2fBwH6CupA

"The Federal Trade Commission has ordered Illumina to divest cancer screening company Grail, arguing the $8bn acquisition would damage competition in the US market for life-saving cancer tests."

https://www.ft.com/content/3848cf02-8d00-4286-ab96-f3d72bde3c8e