Thiago Carvalho @cyrilpedia@social.cleverlibre.org

'While we have focused on mice, it should be noted that rats may be advantageous in some circumstances. For example, while nearly all mouse models of breast cancer are estrogen-receptor negative, treatment of rats with the carcinogen N-nitrosomethylurea generates mammary tumors that are estrogen-receptor positive.'

https://www.cell.com/cell/fulltext/S0092-8674(23)00169-1

For the long weekend.

#Mitochondria, powerhouse of the #cell were labeled (cyan) and it's possible to visualize how they reach every corner.

All recorded under the microscope by @KuxJohan & @Marie_Adler23 @cellcommlab

#scicomm #microscopy @focalplane_jcs @Mito_News @MitoAging

The Mighty Krug-Man! #krugman #PaulKrugman

Former politicians and officials who supported the interests of the wealthy find comfortable sinecures at billionaire-supported lobbying firms, think tanks and media organizations. These organizations also help shape what military analysts call the “information space,” defining public discourse in ways that favor the interests of the superrich.

https://www.nytimes.com/2023/04/17/opinion/plutocrats-power-trump.html

Research technician @SanghviLab

https://jobrxiv.org/job/columbia-university-27778-research-technician/?feed_id=44232

#ScienceJobs #job
New York city #UnitedStatesUS #ResearchTechnician
https://jobrxiv.org/job/columbia-university-27778-research-technician/?feed_id=44232

Issue 9 with spotlight on actin:
- Cover on actin remodeling function of plant ribonucleoprotein assemblies
- Regulation of branched vs. linear filaments
- Monomer recycling as determinant of network turnover

Further:
Uptake-independent macrophage killing by Mtb aggregates
How cells coordinate growth with DNA replication and mitosis

https://www.embopress.org/toc/14602075/2023/42/9

Nature editors retract influential cancer paper with “unreliable” data
#Science #Research #Cancer

https://retractionwatch.com/2023/05/01/nature-editors-retract-influential-cancer-paper-with-unreliable-data/

First #preLight post from Aniruddha Das.

👉 https://prelights.biologists.com/highlights/proteasomeid-quantitative-mapping-of-proteasome-interactomes-and-substrates-for-in-vitro-and-in-vivo-studies/

Aniruddha picked a #preprint from the #AOri_lab and team in which proximity labelling is used to identify interactions between the #proteasome and membrane-associated proteins or transcription factors.

'In Finland and Portugal, early career academics seem to require more time on teaching than senior staff. In Norway, the opposite applies, early career academic roles list more research related criteria.'

https://blogs.lse.ac.uk/impactofsocialsciences/2023/02/13/what-40000-job-adverts-say-about-academic-career-progression/

A CRISPR atlas of human CD8 cells.

"We developed pooled CRISPR screening approaches with compact epigenome editors to systematically profile the effects of activation and repression of 120 transcription factors and epigenetic modifiers on human CD8+ T cell state."
#Preprint #Immunology

https://www.biorxiv.org/content/10.1101/2023.05.01.538906v1?med=mas

'Outside of mammals, few examples of immunostimulatory LPS activities (or LPS receptors) exist. Indeed, the genes encoding the mammalian LPS receptors CD14, TLR4, and MD2 are absent from the genomes of fish and invertebrates (which constitute >90% of metazoan life). Thus, exceptions to the error-centric theme of pattern recognition may be a recent evolutionary innovation'

https://www.science.org/doi/10.1126/science.ade9733

'Health-sector governance should promote collaboration and solidarity between countries, not encourage competition and gatekeeping in the development of lifesaving products. The pandemic has already demonstrated why we need such a shift in perspective.'

https://www.project-syndicate.org/commentary/drug-development-health-innovation-public-funding-needs-more-conditions-by-mariana-mazzucato-2023-04?barrier=accesspaylog

Beatrix Potter is best remembered for her charming tales of Peter Rabbit, but did you know she also studied #science?

Potter collected & examined beetles, butterflies, plants, bird eggs, shells, rocks, fossils & especially fungi. She conducted experiments & wrote a scientific paper with her own illustrations, presented at the Linnean Society of London. However, as a woman in the Victorian era, she couldn’t even attend the meeting. https://www.nytimes.com/2023/04/26/arts/design/beatrix-potter-peter-rabbit-science.html?smid=nytcore-ios-share&referringSource=articleShare #HistoryRemix #history #art #books

Associate Research Scientist @ZuckermanBrain

https://jobrxiv.org/job/associate-research-scientist-11/?feed_id=44172

#ScienceJobs #job
New York City #UnitedStatesUS #Researcher #Scientist
https://jobrxiv.org/job/associate-research-scientist-11/?feed_id=44172

#Viralimmunology A brief overview of how #SARSCoV2 evade or inactivate the host #innateimmunity
📌 https://www.sciencedirect.com/science/article/pii/S0925443923000376
📌 https://www.sciencedirect.com/journal/biochimica-et-biophysica-acta-bba-molecular-basis-of-disease/vol/1869/issue/6