Thiago Carvalho @cyrilpedia@social.cleverlibre.org

'Marsella, capital de la Provenza, es una ciudad de ciudades, la más antigua y la más diversa de Francia. Una muñeca rusa que entraña tantas posibilidades como ambición tenga cada visitante.'

https://elpais.com/elviajero/2023-05-03/manual-de-uso-para-no-perderse-nada-en-marsella-arte-urbano-escenarios-literarios-y-sitios-para-comer.html

'Our findings demonstrate that developmental bias in fly wings predicts evolvability and macroevolutionary trajectories on a much greater scale than previously appreciated but also suggest that causal explanations for such alignments may go beyond simple constraint hypotheses.'
#Evolution #EvoDevo

https://www.pnas.org/doi/10.1073/pnas.2211210120

This is definitely an area where it makes sense that AI could outperform humans.

'The new methodology is “remarkable”, says Dave Mauger, a computational RNA biologist who previously worked at Moderna in Cambridge, Massachusetts, a maker of mRNA vaccines. “The computational efficiency is really impressive and more sophisticated than anything that has come before.”

https://www.nature.com/articles/d41586-023-01487-y

A reference framework to normalize human lymphocyte numbers in ageing.

'In this study, we analyze cross-sectional numbers of mainly T lymphocytes (CD3+, CD3+CD4+, and CD3+CD8+) and their subpopulations (naive and memory) from 673 healthy Dutch individuals ranging from infancy to adulthood (0–62 y). We fitted the data by a delayed exponential function and estimated parameters for each lymphocyte subset.'
#Immunology #Ageing

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2200520/263658/Age-Dependent-Normalization-Functions-for-T?redirectedFrom=fulltext

The Invisible Cities is a book everyone should read.

"No matter how fantastical those places are in Invisible Cities, he reveals that they’re all Venice. They’re all basically Marco Polo riffing about Venice. It’s his childhood home. Calvino touches on the idea of nostalgia, and I think in the ancient Greek sense of nostalgia—in trying to get home, you go off and you have these adventures"

https://lithub.com/darran-anderson-on-the-ever-shifting-magic-of-italo-calvinos-invisible-cities/

"Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding of their clinical relevance remains largely incomplete. To systematically decipher the effects of human genetic variants, we obtained whole genome sequencing data for 809 individuals from 233 primate species, and identified 4.3 million common protein-altering variants with orthologs in human."
#Preprint #Genomics #GeneticVariaton

https://www.biorxiv.org/content/10.1101/2023.05.01.538953v2

"To capture the complex interplay between the tumor antigenic landscape and anti-tumor immunity in lung cancer, we integrated genomics, transcriptomics, immunopeptidomics, spatial transcriptomics and multiplexed immunofluorescence (mIF) imaging to investigate the antigenic landscape in tumors with variable degrees of immune infiltration"
#Immunology #immunooncology

https://www.nature.com/articles/s43018-023-00548-5

'Pfizer said it would begin offloading its 32 per cent stake in consumer health business Haleon as it focuses on reducing debt linked to its $43bn acquisition of Seagen and boosting returns to shareholders.'

https://www.ft.com/content/ec441144-52ae-4fa2-8a04-4238db0ee504

'A single dose of the human papillomavirus vaccine is highly effective at preventing infections over three years, most likely lowering rates of cervical cancer and other diseases linked to the virus, according to a new study in Kenya.'

https://www.nytimes.com/2023/05/02/health/hpv-vaccine-dose.html?action=click&module=Well&pgtype=Homepage&section=Health