Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
STM is looking for an editor with experience in cardiovascular/vascular research.
'The American Association for the Advancement of Science (AAAS) and Science Translational Medicine are seeking a talented scientist, physician scientist or clinician interested in biomedical/translational research to join the Science Translational Medicine editorial team, preferably in our Washington, DC, USA or Cambridge, UK offices.'
#ScienceJobs #ScienceCommunication
'Reconvertir el viñedo en ecológico significa que todas las prácticas como el abonado, con productos fitosanitarios contra las plagas de la viña y la erradicación de malas hierbas, se ajustan a la legislación ecológica. Este plan obedece, según la enóloga de la bodega, Elisa Ludeña, a la responsabilidad que existe por parte de la propiedad en “cuanto al cuidado del suelo y de la biodiversidad y a la restricción del uso de productos químicos de síntesis”.
'In a section that suggests those closest to Johnson at the time have been obliging in spilling the beans, Seldon describes how Johnson, digesting the results at his London home, “paced around in a Brazilian football shirt and bottom-hugging shorts looking ashen-faced and distraught”. A new thought struck him: “Oh s**t, we’ve got no plan. We haven’t thought about it. I didn’t think it would happen. Holy crap, what will we do?”
https://www.ft.com/content/4288182d-db70-4bcc-9db2-fef88a0a5cf5
Thiago Carvalho
boosted
#CharlieSausageFingersGoldenHatParade #Coronation
Monty Python: "Strange women lying in ponds distributing swords is no basis for a system of government…"
The Royal Family:
Thiago Carvalho
boosted
"Berners-Lee eventually convinced CERN to release the World Wide Web into the public domain without any patents or fees. He has since attributed the runaway success of the web to that single decision."
30 years ago, one decision altered the course of our connected world
https://www.npr.org/2023/04/30/1172276538/world-wide-web-internet-anniversary
Thiago Carvalho
boosted
‘A race it might be impossible to stop’: how worried should we be about AI? https://www.theguardian.com/technology/2023/may/07/a-race-it-might-be-impossible-to-stop-how-worried-should-we-be-about-ai?CMP=share_btn_tw
'The EU is ready to agree that immediate open access to papers reporting publicly funded research should become the norm, without authors having to pay fees, and that the bloc should support non-profit scholarly publishing models.'
Molecular atlas for Crohn's disease & ulcerative colitis in patients receiving anti-TNF.
'We describe a therapeutic atlas for Crohn's disease (CD) and ulcerative colitis (UC) following anti-tumour necrosis factor (TNF) therapy. We generated ~1 million single-cell transcriptomes, organised into 109 cell states, from 216 gut biopsies from 38 patients and three controls, revealing disease- and therapy-specific differences.'
#Preprint #IBD #ulcerativecolitis #crohnsdisease #immunology #TNF #immunotherapy #mucosalimmunology
Thiago Carvalho
boosted
@cyrilpedia
What an interesting paper, thank you for sharing.
The data and experiments look very solid. One comment - fig 1c is doing quite a lot of the heavy lifting in showing the specific induction of IL-24. Looks fair but how often is an injury just epidermis deep? If you get dermal injury, then IL-1b looks almost as specific a cytokine induced. Anyway, that's a separate story. IL-24 as an important local skin danger signal, I'm sold.
Thiago Carvalho
boosted
Today the government’s anti-democratic mission is seen clearly. As well as suppressing dissent through draconian anti-protest laws, the Met used live facial recognition surveillance during the coronation.
These are the tactics of authoritarian regimes.
In a democracy, protest is a fundamental right. #protest #coronation #policing #humanrights
https://time.com/6277591/anti-monarchy-protesters-arrested-king-charles-coronation/
Thiago Carvalho
boosted
Just in case anyone didn’t know, the police are currently arresting anyone peacefully protesting against the coronation and its lavish extravagance during a time of national need.
Currently. Arresting. Peaceful. Protestors.
This is not my country. This is a dystopia.
Thiago Carvalho
boosted
Thiago Carvalho
boosted
'These distinct roles for EZH2 in promoting prostate cancer progression, metastasis, and AR independence raise the possibility that it could be a potential therapeutic target in advanced disease.'
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002038
Thiago Carvalho
boosted
Born in 1902, botanist & cytogeneticist Barbara McClintock became a pioneer in modern genetics by changing our understanding of inheritance.
She proposed that genomic replication does not always follow a consistent pattern, which wasn’t widely accepted at the time. She also contributed new cytogenetic research techniques & was the first scientist to correctly speculate about epigenetics.
In 1983, McClintock was awarded a Nobel Prize. https://www.nobelprize.org/womenwhochangedscience/stories/barbara-mcclintock #HistoryRemix #science #history
Thiago Carvalho
boosted
"Menopause costs American women an estimated $1.8 billion in lost working time per year, according to a Mayo Clinic study published this week. The paper examined how hot flashes, night sweats, mood swings and the myriad other symptoms associated with this time of life affect women in the workplace. It’s the largest study of its kind to have been done in the United States."
Thiago Carvalho
boosted
'The European People’s party, which has the most seats in the European parliament and is in power in nine countries across the EU, will call on Friday to scrap two flagship pieces of legislation put forward by their own European Commission president, Ursula von der Leyen. The move could torpedo the commission’s plans to cut pesticide use in half and rewild a fifth of damaged habitats across the bloc by 2030.'
https://www.ft.com/content/38f5801e-a68c-4328-b467-a07ee7fbd94d
@mucida The paper also has a very interesting evolutionary scenario
"Unbiased phylogenetic analyses indicated that this family and its receptors28 share greater sequence/structure homology to IFN and IFN-receptors than other cytokines/cytokine-receptors (Figures S1A and S1B; Table S3). Notably, the heterodimeric receptor subunits of the IFN and IL-10 families also sub-clustered, suggestive of a common ancestral heterodimeric receptor specific to these two families (Figure S1B). In contrast to IFNs, however, the IL-10 cytokine family has not been as clearly linked to pathogens/danger signals. This raises the tantalizing possibility that, during evolution, these pathways may have bifurcated from a common ancestor to cope with the increasing diversity of pathogens and injuries."
Thiago Carvalho
boosted
Clarence Thomas Promises To Adopt Code Of Ethics For The Right Price
https://www.theonion.com/clarence-thomas-promises-to-adopt-code-of-ethics-for-th-1850409408
'We now provide compelling evidence that in hypoxic conditions, an autocrine IL-24/IL-24-receptor signaling/STAT3 loop is induced, which then sustains the HIF1α-mediated expression of epidermal IL-24. In turn, IL-24 acts in an autocrine and paracrine fashion to coordinate re-epithelialization, re-vascularization, dermal fibroblast proliferation, and collagen deposition to restore the damaged tissue to homeostasis.'
Liu, @mucida, Fuchs et al
“Older adults, in particular those with underlying health conditions, such as heart or lung disease or weakened immune systems, are at high risk for severe disease caused by RSV,” said Dr. Peter Marks, director of the FDA’s Center for Biologics Evaluation and Research, in a statement. “Today’s approval of the first RSV vaccine is an important public health achievement to prevent a disease which can be life-threatening and reflects the FDA’s continued commitment to facilitating the development of safe and effective vaccines for use in the United States.”
https://edition.cnn.com/2023/05/03/health/first-rsv-vaccine-approved/index.html
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
