Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
#DrugDiscovery #Drugdevelopment #viralimmunology @Nature summarize the most recently developed broad-spectrum fusion inhibitors (neutralizing antibodies, peptides, proteins, small-molecule compounds) & candidate #vaccines targeting the conserved elements in #SARSCoV2 S2 subunit
📌 https://www.nature.com/articles/s41392-023-01472-x
📌 https://www.nature.com/sigtrans/
Thiago Carvalho
boosted
Two important, groundbreaking studies on pancreatic cance this week. I reviewed them here https://erictopol.substack.com/p/a-one-two-punch-against-pancreatic
Thiago Carvalho
boosted
unearned prestige https://sometimesimwrong.typepad.com/wrong/2023/05/unearned-prestige.html
Make sure to read until the end. Final paragraph is the most important one: "more radical thing ... to make science more transparent and equitable is to take back control of how we allocate prestige. we don't need to wait for journals to reform themselves ... there's no reason to think journals will ever do that - most of them are in business of chasing impact and profits, so why would we expect them to change? it's time to move on."
'Schools have also been targeted, with right-wing pressure groups such as ‘Moms for Liberty’ recognising no irony as they oppose the freedom to read, through controlling which books are stocked in classrooms or school libraries. One of the books the group sought to ban in Tennessee was Ruby Bridges Goes to School, which celebrates racial integration in schools.'
'They observed the significant induction of IFNβ and other inducible chemokines in the medium of primary microglia treated with tau fibrils, which was abrogated by the genetic ablation of Cgas. This raised a question: how does tau protein activate this DNA sensor? Through a series of clever in vitro experiments, the authors demonstrated that tau fibrils localize to microglial lysosomes and mitochondria and that they promote the release of mitochondrial DNA (mtDNA) to the cytosol'
"A panel of advisers to the Food and Drug Administration voted unanimously on Wednesday that the benefits of making a birth control pill available without a prescription outweigh the risks, a significant step in the decades-long push to make oral contraception obtainable over the counter in the United States."
https://www.nytimes.com/2023/05/10/health/fda-otc-birth-control-pill.html
'For seventy percent of us with ME/CFS, the illness that tore our lives apart started with a viral infection. We knew, when Covid-19 struck, that we would soon be hearing about a chronic, debilitating post-Covid syndrome devastating the lives of an entirely new influx of people.'
https://lithub.com/how-chaos-theory-can-revitalize-and-save-modern-medicine/
Thiago Carvalho
boosted
'We find that naïve-like T cells in zebrafish organize into a previously undescribed whole-body lymphoid network that supports streaming migration and coordinated trafficking through the host. This network has the cellular hallmarks of a mammalian lymph node, including naïve T cells and CCR7-ligand expressing nonhematopoietic cells, and facilitates rapid collective migration.'
Thiago Carvalho
boosted
CART cells beyond cancer - my latest Clinical Pipeline column for Nature Medicine is out. CAR T cell technology in humans was first tried for HIV in the 90s. Now veteran HIV researchers are giving them another shot.
#immunotherapy #publichealth #hiv #Immunology #cartcells
#ScienceCommunication #SciComm #InfectiousDisease
Thiago Carvalho
boosted
Finally, a solution to the unfairness of authorship ordering in scientific papers! 😂
"Every Author as First Author"
The Max Planck Institute for Biology of Ageing in Cologne is recruiting a junior PI
#ScienceJobs
https://recruitingapp-2695.de.umantis.com/Vacancies/447/Description/1
'We find that naïve-like T cells in zebrafish organize into a previously undescribed whole-body lymphoid network that supports streaming migration and coordinated trafficking through the host. This network has the cellular hallmarks of a mammalian lymph node, including naïve T cells and CCR7-ligand expressing nonhematopoietic cells, and facilitates rapid collective migration.'
'The ‘continuous urge to win the battle’ may extend to physicians, they noted. Oncologists’ desire for ‘victory’ over cancer may be detrimental to their patients if they’re inclined to prescribe inappropriately aggressive treatments. And patients, wishing to ‘beat’ cancer, may be reluctant to accept palliative or hospice care.'
https://aeon.co/essays/should-we-abandon-the-idea-that-cancer-is-something-to-fight
'Prime minister Rishi Sunak is at pains to insist that “the police are operationally independent of government”, which might be a little too convenient. I’m not sure you get to pass draconian new legislation into law a mere three days before the coronation, then claim its prompt misuse has nothing to do with you.'
Thiago Carvalho
boosted
Potentially good news that the EU is considering to move beyond #OpenAccess mandates and do away with author publication fees - and fund scientific publication directly.
To me, one problem in the way we talk about this is the tendency to discuss "journals" as a monolithic entity. On a previous episode of the #EMBOPodcast Adriano Aguzzi, Thomas Lemberger & I discussed if funding agencies should establish stricter parameters for which journals could be funded. The community can rate what matters - this is the sort of thing that could give DORA principles some teeth for example. Quality peer review, track record of publishing reliable work, inclusivity, tools for data analysis, etc.
If you want to jump to this bit in the episode ("From Prions to Preprints"), go to minute 19.
Thiago Carvalho
boosted
'Even within one rare disease, many subtypes can exist that require personalized approaches to therapy. As one example, EMA’s chief medical officer Steffen Thirstrup mentions cystic fibrosis, which affects around 1 in 2,500 babies born. “When I left medical school 30 years ago, we knew that cystic fibrosis was caused by a genetic defect, but now we know that different mutations in the genome can cause this disease,” he explains.'
#raredisease
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
