Thiago Carvalho @cyrilpedia@social.cleverlibre.org

'This is also a broader issue. The UK’s share of global pharma R&D has dropped sharply since 2012, from 7.7 per cent to 4.2 per cent in 2020. Manufacturing has fallen since 2015, according to the Association of the British Pharmaceutical Industry, along with exports. '

https://www.ft.com/content/aed6c929-6eeb-4f6d-bce7-d36445fc5ebf

'All​ over Europe, the police made the mistake of assuming that the next revolutionary outbreak would be the work of a handful of trained conspirators. The explosion of almost spontaneous mass uprisings by ‘the people’ – the pattern of 1848 – took governments, liberal reformers and even Count Metternich, the supreme architect of Europe’s post-1815 order, by surprise'

https://www.lrb.co.uk/the-paper/v45/n11/neal-ascherson/kings-grew-pale

'The essential problem is that human language is not just about saying what and where things are and which qualities they harbor, such as being green or tall. Language is about what happened, what’s different, what’s on the move. At its core, language is all about the action — to wit, the verbs.'

https://www.nytimes.com/2023/06/01/opinion/verbs-language-instruction.html?action=click&module=Well&pgtype=Homepage&section=Guest%20Essays

'At best, Brenner says, scientists can develop therapies that maintain the health of older people and help keep them out of the hospital—an increasingly important goal as the average age in the United States and elsewhere keeps climbing. Brenner is tackling this problem as the chief scientific advisor of a bioscience company called ChromaDex, which markets supplements for “healthy aging.” But believing we can rewrite the operating manual for lifespan itself, Brenner told me, is like “believing in the tooth fairy.”

https://nautil.us/the-longevity-skeptic-305806/

'We posit that future models purporting to explain the etiology of mammalian mutagenesis need to capture the fact that more closely related species have more similar mutation spectra; a model that fits each marginal spectrum with high cosine similarity is not guaranteed to capture this hierarchy of mutation spectrum variation among species.'

#preprint
https://www.biorxiv.org/content/10.1101/2023.05.31.543114v1

Outra grande ideia do Moedas:

'Sobretudo esta ideia de tirar os pobres do centro da cidade e juntá-los a outros pobres que vivem em bairros sociais é uma ideia errada e ultrapassada de cidade. Estigmatizar cada vez mais os bairros carenciados e limpar as zonas privilegiadas da cidade do mau aspeto de quem literalmente não tem onde cair morto. Como é que ainda estamos aqui?'

https://www.publico.pt/2023/06/02/opiniao/opiniao/arrumar-pobres-devido-lugar-2051888

'What particularly impressed Tolstoy’s contemporaries was his seemingly superhuman ability to trace Prince Andrei’s thoughts after he loses the ability to communicate with others. “How does Count Tolstoy know [all] this?” asked the novelist Konstantin Leontiev. “He did not rise from the dead and visit us after his resurrection.” And yet he convinces readers that, yes, it could really be just this way.'

https://www.nybooks.com/articles/2023/06/22/death-and-the-hedgehog-tolstoy-as-philosopher/

AKT inhibitor in breast cancer

https://www.nejm.org/doi/full/10.1056/NEJMoa2214131?query=featured_home

"Sixteen months after his infection, Mr. Muñoz’s lungs have recovered somewhat, but not completely. The large areas of cysts are gone, but there is still cratered scarring."

https://www.nytimes.com/interactive/2023/05/31/health/covid-lung-damage.html

"Dr. Montenegro, sim ou não?
Esta semana, no Telejornal da RTP, a pergunta foi simples. A resposta queria-se transparente. Sim ou não. O PSD de Luís Montenegro contará ou não com o apoio do partido de extrema-direita, Chega, para governar? No entanto, Montenegro não soube responder."

https://www.publico.pt/2023/06/01/opiniao/opiniao/dr-montenegro-sim-nao-2051739