New article! Read A Strep A vaccine global demand and return on investment forecast to inform industry research and development prioritization https://www.nature.com/articles/s41541-023-00690-2?utm_source=dlvr.it&utm_medium=mastodon in npj Vaccines
Some #AntiviralDrugs act by triggering viral "Death by #Mutagenesis", but could this accelerate evolution of variants-of-concern? @Gabriela3001 @TPilpel @DrMANowak use a math framework to ask whether such treatments are evolutionarily safe #PLOSBiology https://plos.io/45mSjJe
Florida man gets unexplained leprosy case https://arstechnica.com/?p=1959775
"The study, published on 3 August in Science, could open the floodgates to linking the genomes of historical people to their present-day descendants — some direct, but most very distant. This approach could be especially resonant for African Americans and members of other populations around the world who trace some of their ancestry to enslaved people, say researchers."
Both doctors and patients can feel anxious about when and how to stop medicines safely.
What light does a new study shed on this process?
@nihrevidence
https://www.bmj.com/content/382/bmj.p1708
The Oldest Known Photographs of Rome (1841-1871) https://www.openculture.com/2023/08/the-oldest-known-photographs-of-rome-1841-1871.html
'É sabido que a palavra “trabalhador” tem um peso que a muitos desagrada. Preferem dizer “colaborador”. Um colaborador é aquele que não se assume em luta pelos seus direitos e, ainda menos, em reivindicação perante a sua entidade empregadora por melhores condições de trabalho.'
https://www.publico.pt/2023/08/09/opiniao/opiniao/salario-emocional-colaboradores-2059661
"Indeed, it turns out that a host of potentially infectious disease agents can live on microplastics, including parasites, bacteria, fungi, and viruses."
Care to share? Experimental evidence on code sharing behavior in the social sciences
> “Taken together, our results highlight that the availability of research code will hardly be enhanced by small-scale individual interventions but instead requires large-scale institutional norms”
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0289380
Forty-one migrants are reported to have died in a shipwreck off Lampedusa.
https://www.rainews.it/articoli/2023/08/migranti-naufragio-al-largo-di-lampedusa-41-morti--lo-hanno-raccontato-i-quattro-sopravvissuti-125f08ba-ca0a-4f01-ab6d-f5f4370bc05d.html #Italy
The navigational, cartographic, astronomical, and other writings of the gentlemanly humanist scholar Thomas Blundeville (c. 1522–c. 1606) #HistoryOfNavigation #HistoryOfCartography #HistoryOfAstronomy #HistoryOfMathematics
https://thonyc.wordpress.com/2023/08/09/the-equestrian-country-gentleman-who-turned-his-hand-to-navigation/
Into the #Unknome. The function of many human genes still remains mysterious; @mjafreeman, Sean Munro &co present an “Unknome database,” and show that screens focusing on the "Unknome" can shed light on fundamental biological processes #PLOSBiology https://plos.io/3YqumhS
Folding stabilities of ribosome-bound nascent polypeptides probed by mass spectrometry | https://www.pnas.org/doi/10.1073/pnas.2303167120 #proteomics
Suspension Trapping-Based Sample Preparation Workflow for In-Depth Plant Phosphoproteomics | https://pubs.acs.org/doi/10.1021/acs.analchem.3c00786 #proteomics
Scientists discover new #ecosystem underneath #hydrothermal vents.
Using an underwater robot, the science team overturned chunks of volcanic crust, discovering cave systems teeming with worms, snails, and chemosynthetic #bacteria living in 25°C water.
Additionally, they found evidence of vent animals, like #tubeworms, traveling underneath the seafloor through vent fluid to colonize new habitats.
#biology #ecology
https://phys.org/news/2023-08-scientists-ecosystem-hydrothermal-vents.html
'One problem with personalized medicine is the cost. As the bills for his biopsies, surgeries and radiation piled up, we started to call my father the “million-dollar man.” The real eyepopper was the erlotinib, priced at over $5,000 for a one-month supply of the tiny pills.'
#drugdiscovery #drugdevelopment #publichealth
"This series consists of three-dimensional and collapsable (pop-up) collages, made inside cardboard boxes. The images used are engravings and illustrations found in a german encyclopedia published in the 1930’s.
Scales range from 15cmx21cm to 21x28cm."
"The evolution of SARS-CoV-2 shows a novel pattern compared with that of influenza virus or seasonal coronaviruses, which demands a booster vaccine with broad-spectrum protection against emerging SARS-CoV-2 variants."
#covid19 #vaccines #evolution #SARSCoV2 #Pandemic
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00299-8
“These guys did something that I thought was very innovative and inventive,” said Paul Blumenthal, a professor of obstetrics and gynecology at Stanford University and one of the authors of the editorial accompanying the paper. He was not a part of this study. “I remember reflecting to myself when this paper came through … ‘Oh my goodness, after all this time, we don’t have good data on menstrual pads or menstrual products and their capacities?’”
https://www.statnews.com/2023/08/07/period-products-menstrual-disc-new-study/
"The Food and Drug Administration on Friday approved the first pill for postpartum depression, a milestone considered likely to increase recognition and treatment of a debilitating condition that afflicts about a half-million women in the United States every year."
https://www.nytimes.com/2023/08/04/health/postpartum-depression-pill-fda.html?action=click&module=Well&pgtype=Homepage§ion=Health
In April I wrote about how this new class of drugs were developed for #NatureMedicine. Read it at the link below:
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com