Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Check out our lab's #newpaper in @cellpress Cell:
We found that the skull is special - its marrow is a special immunologic niche. Skull #Immune #cells can move to the meninges via skull-meninges connections, which we found both in mice and humans with #tissueclearing and #lightsheet #microscopy.
We also bring #proteomics and #PETimaging to the mix!

Paper: https://doi.org/10.1016/j.cell.2023.07.009

Explainer thread:
https://bird.makeup/users/erturklab/statuses/1689293936185991169

Please help solve a mystery! I'm working on a long-suffering book chapter, & we're at the copyright approvals part. We had been using this figure about the yeast life cycle, but no one can remember the original source. 0 results on reverse image search! Look familiar to anyone?

Opa!

Tem número recém-lançado da revista Nova Economia. Tem artigos de micro, macro, HPE e muito mais. Tem artigos em português e em inglês, ao gosto de cada freguês. E tem esta capa... simplesmente sensacional!

Tudo isso com acesso aberto em https://revistas.face.ufmg.br/index.php/novaeconomia/issue/view/407

Nova Economia é a revista do Departamento de Ciências Econômicas da #UFMG

#economia

'Cuando finalmente aborda el atentado a Schneider, que acabó con su muerte tras agonizar -el plan era secuestrarlo, no asesinarlo-, Kissinger le plantea a Nixon que hubo “un giro para peor, pero no ha desencadenado nada más”. “El movimiento siguiente debería haber sido la toma de posesión del Gobierno [por parte de los militares], pero no ha ocurrido”. La de idea Washington era crear un “clima golpista”.

https://elpais.com/chile/2023-08-09/kissinger-a-nixon-en-1970-los-militares-chilenos-son-un-grupo-bastante-incompetente.html

"It is well established that Hsp70 upregulation during post-heat shock stimulus is mediated by cap-dependent translation. However, the molecular mechanisms of Hsp70 expression during heat shock stimulus remains elusive"
#Preprint

https://www.biorxiv.org/content/10.1101/2023.02.22.529618v2

In macaques:

"The pattern of infection observed suggests that ZIKV vertically transmits not through a transplacental route but through a paraplacental route by infecting the chorionic membrane, the outer layer of the fetal membranes. This finding is significant because it challenges the assumption that vertical transmission occurs exclusively across the placenta."

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011274

"They have investigated the brains of ageing mice, elucidating the source of the cGAS–STING trigger and the particular cells in which this pathway is activated (Fig. 1). Specifically, the authors find that cytosolic DNA derived from perturbed mitochondria activates the pathway in ageing microglia, the main immune cells in the brain — an observation that agrees with earlier findings that cGAS–STING is involved in activating microglia and in neuroinflammation"
#Immunology #Neuroimmunology #NeurodegenerativeDisease #InnateImmunity

https://www.nature.com/articles/d41586-023-02240-1

The African turquoise killifish is a short-lived fish species that's a novel vertebrate model to study aging and other physiological processes.

Anne Brunet has a new lab manual telling you all you need to know about it.

http://cshlpress.com/default.tpl?action=full&--eqskudatarq=1379

Deadline is 11 August 2023 to apply for a Travelling Fellowships from
@Dev_journal
@J_Cell_Sci
@J_Exp_Biol
&
@DMM_Journal
. £3,000 available to #PhD students and #postdocs to make collaborative visits to other laboratories. Apply at: https://t.co/j9PUHgaa5Q

🔬The fascinating world of Basement Membranes🔬
@uwe689
and colleagues shed more light on BM and its pivotal role in tissue structure, cell migration and morphogenesis. Read the #OpenAccess 🔓#Review here: https://journals.biologists.com/bio/article/12/8/bio059980/325754/Basement-membrane-dynamics-and-mechanics-in-tissue

Risk of ischemic stroke after #COVID19 recovery: overall population
https://journals.sagepub.com/doi/10.1177/23969873231190432

Senior Research Investigator -- Computational Biology

Center for Cytokine Storm Treatment and Laboratory, Perelman School of Medicine, University of Pennsylvania

Come join us at the Center for Cytokine Storm Treatment and Laboratory within the Perelman School of Medicine at Penn as a #bioinf...
https://jobrxiv.org/job/center-for-cytokine-storm-treatment-and-laboratory-perelman-school-of-medicine-university-of-pennsylvania-27778-senior-research-investigator-computational-biology/?feed_id=54401

In the latest podcast episode of #HABgehört, Dr Stephanie Leitch, curator of the 45th #HAB_WF Summer Course "Early Modern Visual Data: Organising Knowledge in Printed Books" is our first English-speaking guest!
Listen via any podcatcher app or our website: https://www.hab.de/early-modern-visual-data/

A reminder that Canada’s pandemic alert system, GPHIN, collapsed in 2019 just before the arrival of #COVID19, and we paid a price for it. https://theglobeandmail.com/canada/article-what-happened-with-canadas-pandemic-alert-system-the-gphin/?utm_medium=Referrer:+Social+Network+/+Media&utm_campaign=Shared+Web+Article+Links

'While extensive research has focused on mitochondrial dNTP homeostasis due to its defects being associated with various mitochondrial DNA (mtDNA) depletion and deletion syndromes, the investigation of mitochondrial rNTP homeostasis has received relatively little attention.'
#mitochondria

https://www.embopress.org/doi/full/10.15252/embj.2023114990

'A story that has an experimental or mysterious structure turns you into a detective, trying to figure out not just what happened, but also why the writing is the way it is. To me, the most delightful work in this vein is If on a Winter’s Night a Traveler, by Italo Calvino'

https://www.theatlantic.com/books/archive/2023/08/attention-focus-book-recommendations/674941/

'The “care home” was in fact a recent rebrand of one of Ireland’s notorious Magdalene laundries run by the Roman Catholic Church. Between the eighteenth and twentieth centuries tens of thousands of Irish women, pregnant and unwed or simply, like O’Connor, deemed “difficult,” were disappeared into such institutions. In addition to their incarceration and punitive abuse, the women were used as forced labor.'

https://www.nybooks.com/online/2023/08/05/incomparable-sinead-oconnor/

'In contrast to the pathological activation of the immune system by metabolic stress, little attention has been paid to the physiological role of the immune system in regulating energy supply. In fact, the primary function of the immune system is to ensure tissue integrity and repair, thereby maintaining homeostasis.'
#Immunology & #Metabolism

https://www.cell.com/trends/immunology/fulltext/S1471-4906(23)00110-2