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@gpollara this paper supports the message we sent out when we reported the presence of a 'Viral storm' in severe covid-19 also in Lancet Microbe, linked to a more evident dysregulated response. We proposed that preventing this viral storm could prevent hyperinflammation thelancet.com/journals/lanmic/

"All parts of knowledge have their origin in metaphysics, and finally, perhaps, revolve into it."
De Quincey's Writings (ed. 1854)

Thomas De Quincey was born #OTD in 1785. He is best known for his Confessions of an English Opium-Eater. Many scholars suggest that in publishing this work De Quincey inaugurated the tradition of addiction literature in the West. via @wikipedia

Books by Thomas De Quincey at PG:
gutenberg.org/ebooks/author/79

#books #literature

Humans have been making symbols for numbers for thousands of years.

Different cultures developed their own symbols, but all use addition and multiplication, suggesting arithmetic is a universal truth, writes @RandolphGrace (@UCNZ).

theconversation.com/arithmetic

'A recently identified autoimmune disorder called vacuoles, E1 enzyme, X-linked, autoinflammatory, and somatic (VEXAS) provides insight into the synergistic effects of genetic perturbations and stress responses leading to autoinflammation.'
Butera et al @EmboMolMed

embopress.org/doi/full/10.1525

Republicans won’t fight for kids to get school lunch but they’ll fight to make them have a baby? Fuck you, GOP.

Did you know my free online textbook comes with 140 interactive practice questions for your students to test their understanding of p-values, Type 1 and 2 errors, effect sizes, confidence intervals, sample size justification, etc? lakens.github.io/statistical_i

Funny how historical #UFOs always look exactly like human design objects from the period in which they were photographed...
Early-mid- 20th century UFOs all look like Art Deco Bakelite.
Oh, and they have aerials on top because that was the human technology of the day.

As the Beatles would suggest, come together, right now.

"Research on the origin and early evolution of life therefore comprises two areas of understanding that in practice make little contact with one another (Fig. 1). We understand some of the chemistry and geochemical settings that could have led to an origin of life and we can also infer details about early organisms through the most ancient protein families. In practice, however, these two fields of research remain largely disconnected."

pnas.org/doi/10.1073/pnas.2210

'Fifty years ago this month, the best-selling novel and the best-selling nonfiction title in the country had something unusual in common: They were both illustrated.'

nytimes.com/2023/08/10/books/r

"Fazer plantações da mesma casta mas com clones misturados aumenta a estabilidade de comportamento da vinha. Estamos a aumentar a capacidade da videira de amortecer variações [climáticas]", explica Graça.'

publico.pt/2023/08/13/ciencia/

'We used the minimal gene regulatory network of type 1 conventional dendritic cells (cDC1) to reprogram cancer cells into professional antigen-presenting cells (tumor-APCs). Enforced expression of the transcription factors PU.1, IRF8, and BATF3 (PIB) was sufficient to induce the cDC1 phenotype in 36 cell lines derived from human and mouse hematological and solid tumors.'

science.org/doi/10.1126/sciimm

"If justice is blind, she sometimes heads down unpredictable paths. For example, only in Donald Trump’s fourth felony indictment, unsealed last night in Atlanta, has a local prosecutor managed to deliver a sweeping, nationwide view of the former president’s scheme to steal the 2020 election."

theatlantic.com/ideas/archive/

Flights serving the eastern Sicilian city of Catania were halted after an eruption from nearby Mount Etna, local authorities said, bringing fresh travel troubles to the crisis-plagued Italian airport.

Catania’s mayor has banned the use of motorcycles and bikes while many streets in the city remain covered by ash as a result of the erupting volcano.

theguardian.com/world/2023/aug

#Italy #Sicily #Catania #Airport #MountEtna #Volcano

It positively glows with marital bliss

"Yet Jakob Fugger and Sybilla Artzt were man and wife. This painting, by the German artist Hans Burgkmair the Elder, was made to commemorate their wedding in 1498."

ft.com/content/3dbc2126-04eb-4

Do you see power lines (or cable tv or internet fiber) hanging above ground in Europe? No, they are buried, especially near human populations and where there is fire risk. Only high voltage transmission towers near production facilities are seen above ground. But those are designed to withstand high winds, earthquakes, and such---unlike the ancient "technology" of wooden poles barely lifting old cables used by American utilities. It is only the insularity of the USA, including reporting in media such as this article, that prevents the population from understanding that other countries have fixed this problem. It just takes investment from the utility companies to bury the cable and avoid such unnecessary and recurrent tragedy.

Experts Scrutinize Hawaiian Electric as They Search for the Maui Wildfire Cause nytimes.com/2023/08/14/us/hawa

“He could actually read a room and understand how to make it a meaningful experience,” says Hesse, recalling that 1966 Monterey jazz festival performance. “From the first note, he had the people in the palm of his hand and then took them on a journey throughout the entire set.”

theguardian.com/music/2023/aug

In my mind, broadly compatible that faster viral clearance with #COVID19 #vaccination 👉 less antigen 👉 lower inflammatory response.

Further supports hypothesis that #vaccine works by dampening excessive #inflammation to #SarsCoV2, which drives severe disease.
#Immunology

Dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA: a prospective cohort study - The Lancet Microbe

thelancet.com/journals/lanmic/

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