Thiago Carvalho @cyrilpedia@social.cleverlibre.org

"Several years ago it was recognized that the cGAS-STING system was a key part of the inflammation seen in microglial cells in the aging brain (and in the brains of people with neurodegenerative diseases). And this new paper has tracked down further details: the reason this inflammatory pathway has been set off is the leakage of DNA from damaged mitochondria in those microglial cells."

https://www.science.org/content/blog-post/aging-brain-misplaced-dna-blame

'Por muito relevante que seja termos bonecas que façam as meninas sonhar com um futuro possível, é ainda mais importante termos pessoas verdadeiras a fazerem esses feitos.'
@JoanaLA

https://www.publico.pt/2023/08/18/ciencia/opiniao/importancia-visivel-2060497

'Mère Ubu, inspirada en la sátira Ubu rey, del autor francés Alfred Jarry, es eco, para Miró, de la crueldad del déspota, memoria de la dictadura franquista y recordatorio de que la tentación autoritaria sigue anidando en nuestras calles.'

https://elpais.com/opinion/2023-08-19/el-simbolismo-de-la-mere-ubu-de-miro.html

In case you missed it, this was a great conversation with Pavel Tomancak & @tlemberger for the #EMBOPodcast.
Everything from the early days of open science to tips on classic Czech science fiction.
#EMBOPodcast #SciComm #SciencePodcast #DevelopmentalBiology

https://www.embo.org/podcasts/who-reviews-the-reviewers/

Apply now for the Travel Grant from #IBRO for joining our #WinterSchool "Ethics of Neuroscience and AI" (26.2.-1.3.2024)

#computational #neuroscience
@neuroscience @neuro @cogsci @mathcog

https://ibro.org/travel-grants/

https://bccn-berlin.de/events-list/winter-school-ethics-of-neuroscience-and-ai-2024.html

Personalized RNA #vaccines for #melanoma advance to phase III trials (in combination with anti-PD1). My latest Clinical Pipeline column for
@NatureMedicine
#Immunology #Immunotherapy

https://www.nature.com/articles/d41591-023-00072-0

The modern use of placebos in research owes a lot to anesthesiologist Henry K. Beecher and a landmark paper he wrote shining a spotlight on these sugar pills.

Sloppy by today’s standards, and maybe even back when it was published in 1955, Beecher’s paper paved the way for sounder drug trials and pushed scientists to better understand how we process pain

Listen:

🎧 Apple: https://podcasts.apple.com/us/podcast/how-the-placebo-effect-went-mainstream/id1548524996?i=1000618492739
🎧 Spotify: https://open.spotify.com/episode/2x7hsGE1uYQxZXfmX8sCUs

Or wherever you enjoy #podcasts: https://knowmag.org/PodcastS3E3_Mastodon

Accumulation of iron with age may inhibit the benefits of hormone replacement therapy on cardiovascular disease in late postmenopause. https://elifesciences.org/articles/90743?utm_source=mastodon&utm_medium=social&utm_campaign=organic_insights

Robert Reich’s UC Berkeley Course on Wealth & Poverty Is Free Online

https://www.openculture.com/2023/08/wealth-and-poverty-a-free-online-course.html

The @ucdavis Microbiology Graduate Group https://mgg.ucdavis.edu is hosting two "Info Sessions" online for prospective applicants 9/18 and 9/21. Sessions hosted by Program Chair, Admission Committee, students et al.

Register by using QR code or link: https://tinyurl.com/36sctyah

Abstraction of Reward Context Facilitates Relative Reward Coding in Neural Populations of the Macaque Anterior Cingulate Cortex
https://doi.org/10.1523/JNEUROSCI.0292-23.2023

#neuroscience

"When leptin failed, he tried a different gut hormone, ghrelin, whose effects were the opposite of leptin’s. The more ghrelin an animal had, the more it would eat. Perhaps a drug that blocked ghrelin would make people lose weight.

“Again, it wasn’t that simple,” said Dr. Tschöp, who left Lilly in 2002."

https://www.nytimes.com/2023/08/17/health/weight-loss-drugs-obesity-ozempic-wegovy.html

I discussed the origin of these new diabetes and weight loss drugs with Matthias, you can listen to "Obesity is a Brain Disease" scrolling down at the link below.

https://www.pioneercampus.org

Charles Henry Turner, who died in 1923, was a zoologist and comparative psychologist who studied the behavior and cognition of insects and other arthropods including spiders, bees, ants and moths. Researchers are rediscovering the forgotten legacy of this pioneering Black scientist.

Read more in:

🕷️ @KnowableMag: https://arevie.ws/3OBAE9X
🐝 The Annual Review of Entomology https://arevie.ws/TurnerBio_EN

#Science
#ScienceMastodon
#Entomology
#KnowableMagazine

'Alas, the results of most longevity studies are difficult to compare. This is in part because there are no clear, universally accepted standards for conducting such experiments or even for reporting such data.'

https://www.biorxiv.org/content/10.1101/2023.08.17.552381v1

Everyone at West Virginia University Knew Something Was Up. I Hate That We Were Right.

The student population got smaller and smaller while fancy new buildings appeared.

https://slate.com/human-interest/2023/08/west-virginia-university-cuts-programs.html

#WVU #HigherEd #AdministrativeMalpractice

August 19, 1970, the Glomar Challenger discovers first evidence that the Mediterranean Sea repeatedly dried out some 7 million years ago, leaving behind vast deposits of gypsum on the seafloor.

https://forbes.com/sites/davidbressan/2017/09/26/disappearance-of-mediterranean-sea-seven-million-years-ago-triggered-widespread-volcanic-activity/#6ee843df6c24

#IDMastodon @WHO Report comes as 🇺🇸 is experiencing an ⏫️ in hospitalizations & mortality as anticipation mounts for updated vaccines, expected in 🍂
The EG.5 variant could contribute to a surge in cases, the report noted, although there’s no evidence to date that it causes more severe disease.