Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Now published: Mendes de Farias et al, Lessons learned to boost a bioinformatics knowledge base reusability, the Bgee experience https://academic.oup.com/gigascience/article/doi/10.1093/gigascience/giad058/7243539 #KnowledgeBase #bioinformatics #interoperability #FAIR @GigaScience @wikidata #NCBI #SIB #FAIRdata

“One Night Cough Syrup” from the 1930s, which contained cannabis, morphine, chloroform, and alcohol! In 1934, the FDA ruled that the claims of the cough syrup's therapeutic properties were misleading, and remaining stock was destroyed.

Follow me for more medical history content!

#histmed #histsci #histodons #histodon #twitterexodus #twittermigration #medhist #DYK #bigpharma

MGR PROTOCOL REVIEW AND MONITORING SYSTEM

Moffitt Cancer Center

See the full job description on jobRxiv: https://jobrxiv.org/job/mgr-protocol-review-and-monitoring-system/?feed_id=56023

#ScienceJobs #hiring #research
Tampa #UnitedStatesUS
https://jobrxiv.org/job/mgr-protocol-review-and-monitoring-system/?feed_id=56023

'Hay una falta de escrúpulos en cómo tratan la verdad. Joseph Goebbels, el gran jefe de la propaganda nazi, era un maestro de distorsionarla, pero esto ha ido más allá con los populistas de hoy. En cierto modo, no creen que la verdad como tal exista, y esto es muy preocupante, porque hoy en día tenemos redes sociales, y es así como difunden sus mentiras.'

https://elpais.com/ideas/2023-08-18/richard-j-evans-historiador-creer-que-no-hay-verdad-objetiva-abre-la-puerta-a-la-destruccion-de-la-sociedad.html

'These results suggest that hyperactivity of both mTORC1 and mTORC2 are sufficient to cause epilepsy, and that targeted therapies should aim to reduce activity of both complexes.'
#Preprint #neuroscience

https://www.biorxiv.org/content/10.1101/2023.08.18.553856v1

'Moutinho says that, to score a 5, the Lula administration needs to enable more effective surveillance and control of deforestation in all biomes. The government should also act quickly to give a ‘legal status’ to untitled public lands, especially in the Amazon and Cerrado'

https://www.nature.com/articles/d41586-023-02511-x

"Within the confines of the traditional clinical research model, studying novel treatments for rare cancer subtypes is challenging — particularly with respect to patient engagement, financial burden and timeliness. In this issue of Nature Medicine, Liu et al. describe a novel trial design that positions the patient at the focal point of clinical investigation, while exploring the safety and efficacy of first-line pyrotinib in patients with metastatic HER2+ NSCLC"

https://www.nature.com/articles/s41591-023-02466-6

"Let this great maxim be my virtue’s guide,—
In part she is to blame that has been tried:
He comes too near that comes to be denied."
The Lady’s Resolve

Lady Mary Wortley Montagu died #OTD in 1762. She is today chiefly remembered for her Turkish Embassy Letters describing her travels to the Ottoman Empire. In addition, she is also known for introducing and advocating for smallpox inoculation to Britain after her return from Turkey. via @wikipedia

https://www.gutenberg.org/ebooks/author/7433

#books #literature

"Models taken from ‘Stanley Kubrick’s The Shining’, published by Taschen"

https://www.ft.com/content/a9949d9d-08be-4de9-b3a4-f51403d8546b

Meanwhile, in Portugal, one cant go to Madrid by train anymore & all the ruling parties debate is where to put a new airport.

"The Italian state-owned train operator is aiming to launch high-speed rail services between some of Europe’s biggest cities as it takes advantage of the liberalisation of the region’s network."

https://www.ft.com/content/7ccb3037-64f8-45f1-9368-cdc09bd33362

'Stuff aggregates. That's a lesson in drug screening for you in two words! The problem is that lot of the things that we would like to put into solution to run assays doesn't really want to be in solution all that much.'

https://www.science.org/content/blog-post/breaking-aggregates-peg

Hey #cilia & #centrosome peeps, registration is now open for our in-person 🎇 UK Cilia Network Fall meeting🎇 in Edinburgh Friday October 6th, 2023! Our keynote will be from Prof Dagmar Wachten (Bonn, DE) 'Shedding light on ciliary signaling and function'. Lots of talk slots and posters spots too- join us!

Please register: https://forms.office.com/e/EtTDAeGaFY. Deadline for talk and poster consideration is 04/09/2023 17:00.

Boosts welcome!

Dear small businesses: Please don't use facebook as your primary web page. It now requires you to login and some of us have no interest in doing so.

COVID infection could speed up progression of dementia, new study finds.

Research showed patients with various types of dementia all experienced rapid decline in brain function after contracting COVID-19.

#COVID19 #dementia @auscovid19

Source: https://www.express.co.uk/life-style/health/1755139/covid-infection-dementia-progression

‘Orphaned by decree’: Italy’s same-sex parents react to losing their rights

https://www.theguardian.com/world/2023/aug/21/orphaned-by-decree-italy-same-sex-parents-react-losing-rights

It's astonishing just how vicious and nasty the Right is.