Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Postdoc/Researcher Position in Clinical Mass Spectrometry-based Omics at the Steno Diabetes Center Copenhagen | https://jobbank.dk/job/2389680/ #proteomics

"Most recent studies support the hypothesis that T cells worsen disease, but new research from Su et al.4 reported in this issue of Nature Immunology instead describes brain-infiltrating CD8+ T cells as protectors, not perpetrators, of #Alzheimer’s disease pathology."
#Immunology #Neuroimmunology

https://www.nature.com/articles/s41590-023-01622-x

@Kaetchi The initial hypothesis was that the thymus was exerting an endocrine function on gonad development:

"In view of our results, it seems plausible to propose that the thymus has the newly described function of controlling the reproductive faculty in the female mouse."

https://www.science.org/doi/abs/10.1126/science.166.3906.753

PLANTBASED UNIVERSITIES

This Monday we released an open letter signed by over 850 academics, public figures, doctors, politicians, and more! It calls on universities to transition to 100% just and sustainable plant-based catering - for animals, the climate, and us.

Since The Guardian released the story on Monday, we've seen incredible support for our campaign. 

https://www.theguardian.com/environment/2023/sep/04/hundreds-academics-call-for-meat-free-meals-british-universities

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"Although marketed CAR-T therapies have shown transformative efficacy for certain blood cancers, widespread adoption, as well as applicability to solid tumours and autoimmune indications, have been limited by safety, efficacy and operational hurdles. These hurdles include high rates of adverse events such as cytokine release syndrome (CRS), inability to overcome the immunosuppressive microenvironment typically found in solid tumours, and antigen escape and cell exhaustion that reduce durability."

#CARTCells #Immunotherapy #Immunology

https://www.nature.com/articles/d41573-023-00140-7

'The greatest threat to our democracy comes not from demagogues like Mr. Trump or even from extremist followers like those who stormed the Capitol on Jan. 6 but rather from the ordinary politicians, many of them inside the Capitol that day, who protect and enable him.'

https://www.nytimes.com/2023/09/08/opinion/trump-republicans-spain-brazil.html

Closing a loop: The entire modern field of regulatory T cells emerged from the ashes of the suppressor T cell field because of experiments showing destruction of the reproductive system following neonatal thymectomy.

"We found that Treg depletion induces severe autoimmune orchitis and epididymitis, manifested by an exacerbated immune cell infiltration [CD4 T cells, monocytes, and mononuclear phagocytes (MPs)] and the development of antisperm antibodies (ASA)."

#Immunology

https://www.pnas.org/doi/10.1073/pnas.2306797120

Monkey pot. Work in progress by @hunchbacksociety #ceramics #pottery #handmade #artgallery #artmastodon

https://madalenaparreira.com/Hunchbacksociety

A woman walks up a hill in Lanzarote, 2006. The sun is beating down, but she'll be walking into the small shade afforded by the wall of a house.

https://inphotos.org/2023/09/08/from-light-to-shade/

#Lanzarote #CanaryIslands #StreetPhotography #Photo

In #JapaneseFolklore rokurokubi are a type of #yokai appearing as regular women but with the ability to extend their necks to extraordinary lengths (or sometimes completely detach) so their heads can wander around without their bodies. Most rokurokubi just scare people rather than being dangerous. It is believed they were once real women who were transformed into yokai as a result of either a curse or punishment. I have written more about them here: https://www.curiousordinary.com/2023/06/rokurokubi.html
#folklore @folklore

"Why aren't people leaving Twitter?" - I had a call today with a colleague in Europe who manages Twitter ads (among many other tasks) and asked her our plans in light of what's been going on with the platform.

She was completely unaware of what's been going on at Twitter in recent months 🤯. It's a US thing to her so she didn't really pay attention. I'm sending her some links.

Lesson: Don't assume everyone is equally aware of what's going on.

#IDMastodon #virology These observations suggest that BA.2.86 is more closely related to sequences from Southern Africa than other regions & so may have evolved there, and that evolution led to escape from #neutralizingantibodies similar in scale to recently circulating strains of #SARSCoV2.
https://www.medrxiv.org/content/10.1101/2023.09.08.23295250v1.full.pdf

@medrxivpreprint
BA.2.86 showed extensive escape both relative to ancestral virus in sera from pre-Omicron vaccinated individuals and relative to Omicron BA.1 in sera from Omicron BA.1 infected individuals.
https://www.medrxiv.org/content/10.1101/2023.09.08.23295250v1

Her work paved the way for blockbuster obesity drugs. Now, she’s fighting for recognition

Svetlana Mojsov helped discover the hormone GLP-1. Why has she been excluded from its history?

https://www.science.org/content/article/her-work-paved-way-blockbuster-obesity-drugs-now-she-s-fighting-recognition