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"While infection is still prevalent south of the Sahara and in parts of Oceania, such as Papua New Guinea, prior to the 1880s the disease was also endemic in areas that have no longer sustained transmission, including the United States."

asm.org/Articles/2023/Septembe

'These results illuminate an FcγRIIB-mediated, cell-autonomous mechanism of CD8+ T cell suppression, which limits the efficacy of checkpoint inhibitors during antitumor immune responses in vivo.'

science.org/doi/10.1126/scitra

'Researchers who signed up in the past year or so tell Science they committed between $3000 and $6000—plus interest payments on any loans Cheeky Scientist helped them apply for. Hankel declined to comment on the number of people enrolled in the Diamond Program, the company’s pricing strategies, or the program’s content.'

science.org/content/article/cr

'Saura y su equipo sabían que el tumor no se transmite a través de la lactancia, pero a partir de la inquietud de esa paciente, se les “encendió una bombilla”, explica la oncóloga: quizás en esa muestra de leche había ya señales del cáncer que ayudasen a la investigación.'

elpais.com/salud-y-bienestar/2

The best covers are *always* the rejected covers - like this one spotted at @victoralab (Rockefeller) for the LIPSTIC cell-cell contact tracing method.

nature.com/articles/nature2544

With autumn and the virus season approaching, viral levels will go up. We see this in wastewater analysis such as this in the Netherlands. More virus is not great but also does not predict severe disease and hospitalisations, immunity will prevent that.

Deeply troubled to be going in to an emergency HEC to take decisions on behalf of branches and industrial action, without input from a branch delegate meeting in advance of it. Also incredibly troubled that this HEC can be called with less than 24 hours notice, but trying to put one together to implement congress policy on a summer reballot had to take so many weeks that the gap in mandate became inevitable.

"The participants in the group that were given MDMA experienced significantly greater reductions in their PTSD symptoms compared with those in the group that were given a placebo, according to the research article."

nytimes.com/2023/09/14/health/

'The central conundrum in Brazil’s struggle to construct a cultural identity of its own has remained remarkably constant since the first Portuguese explorers arrived in 1500 and encountered Tupi-speaking peoples: To what extent should the European components of the country’s heritage be favored, as opposed to its indigenous and African strands? Or as a group of São Paulo intellectuals memorably phrased it in a manifesto issued nearly a century ago, “Tupi or not Tupi; that is the question.”

nybooks.com/articles/2023/10/0

'Gonsalves’s father recently died after a long descent into dementia. “We need better drugs for neurodegenerative diseases,” he told me. “But the way to do it is not to say, ‘Open the floodgates of the F.D.A.’ ”

newyorker.com/magazine/2023/06

RIP

"You can’t reach an audience on X," Dave Karpf wrote last week. "You can’t organize on X. You can’t follow breaking news on X. The people who made Twitter fun have all given up. There’s nothing worth sticking around for anymore."

defector.com/linda-yaccarino-i

'Yet, as microbiome experts Alan Walker of Aberdeen university and Lesley Hoyles of Nottingham Trent University pointed out recently, in the journal Nature Microbiology, all the excitement “has unfortunately also brought with it hype and entrenched certain misconceptions.” Their article knocks down 12 myths about the microbiome, ranging from exaggerations about its size and weight to misconceptions about the association between some microbial patterns and disease.'

ft.com/content/00619403-fd1a-4

As Florida reports more new #COVID19 hospitalizations than any other state, #GOP sociopath #RonDeSantis demands more sickness and death as surely as if he wrapped his cold, creepy hands around the throats of his constituents and started squeezing. wapo.st/3LltbuZ

Hyperacute rejection

"One photograph of a pig kidney recovered from a baboon at 10 minutes after transplantation shows a blackened lump that resembles more a disaster in a French kitchen than standard organ rejection."

nature.com/articles/d41591-023

When facing the "All we need is STEM!" approach to education, my usual response is:

Developing the vaccine was the STEM problem; distribution & getting shots in arms was the Social Science problem; getting people to trust it & combatting misinformation was the Humanities problem -- which did we fail?

RIP

"You can’t reach an audience on X," Dave Karpf wrote last week. "You can’t organize on X. You can’t follow breaking news on X. The people who made Twitter fun have all given up. There’s nothing worth sticking around for anymore."

defector.com/linda-yaccarino-i

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