Thiago Carvalho @cyrilpedia@social.cleverlibre.org

"The Shasta county board of supervisors appointed Jon Knight, a hydroponics store owner and prominent figure in the local far-right movement, to serve on the board of the public health agency responsible for managing the insects, instead of the county’s former public health director, an epidemiologist."

https://www.theguardian.com/us-news/2023/sep/28/california-shasta-county-far-right-mosquito-vaccine?CMP=share_btn_tw

Please dont write sentences like this. 'An Italian university' has a name, just like Harvard.

"Dr. Gino was something of an academic late bloomer. After growing up in Tione di Trento, a small town in Italy, she earned a Ph.D. in economics and management from an Italian university in 2004, then did a postdoctoral fellowship at Harvard Business School."

https://www.nytimes.com/2023/09/30/business/the-harvard-professor-and-the-bloggers.html

"New data released Thursday by the National Science Foundation show the exodus of young life scientists from the Ivory Tower to industry has reached the highest level in nearly three decades, deepening concerns about the future of academic science in the US"

https://www.statnews.com/2023/09/28/scientists-exodus-from-academia-historic-levels/

Aardvark in progress by @hunchbacksociety

https://madalenaparreira.com/Hunchbacksociety

#Ceramics #Handmade #Art #stoneware #artgallery #artmastodon

“It became the custom in such cases to give credit solely to the one who actually made the experiment work, even if others may have also conceived the idea. It was the drosophilists’ golden rule. Ideas that were engendered in the group’s informal shoptalk were treated as communal resource and not as personal property.”
(Robert E. Kohler, Lords of the Fly)

#Books #Bookshelf #ScienceHistory #SciComm #Drosophila #bookstodon

"Salmonella Typhimurium mutants for spermidine transport and synthesis cannot mount an antioxidative response, resulting in high intracellular ROS levels. These mutants are also compromised in their ability to be phagocytosed by macrophages"

#Microbiology #Preprint #Salmonella #MucosalImmunology #immunology

https://www.biorxiv.org/content/10.1101/2023.09.29.560257v1?med=mas

Merck filed a biologics license application for sotatercept in pulmonary arterial hypertension & now the FDA has granted it priority review.
https://www.merck.com/news/merck-receives-priority-review-from-fda-for-new-biologics-license-application-for-sotatercept-an-activin-signaling-inhibitor-to-treat-adults-with-pulmonary-arterial-hypertension-pah/

I wrote about the drug last fall for Nature Medicine:

"BMPR-II regulates apoptosis and has anti-proliferative effects on pulmonary smooth muscle and endothelial cells. Sotatercept should assist BMPR-II in its tug-of-war with another TGF-beta family member, ActRIIA (which promotes proliferation), by selectively trapping activin pathway ligands. Unlike existing therapies that provide symptomatic management, sotatercept has the potential to be a curative treatment for pulmonary arterial hypertension by modifying the underlying causes of the disease."

https://www.nature.com/articles/d41591-022-00109-w

#DrugDevelopment #Pharma #DrugDiscovery

Tools

"Natural proteins are composed of 20 proteinogenic amino acids and their post-translational modifications (PTMs). However, due to the lack of a suitable nanopore sensor that can simultaneously discriminate between all 20 amino acids and their PTMs, direct sequencing of protein with nanopores has not yet been realized."

https://www.nature.com/articles/s41592-023-02021-8