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"However, it remains unknown how JH3 degradation results in neurodevelopmental outcomes that translate into distinct worker behaviors, how this is accomplished at the molecular and cellular level, and whether differential regulation of JH3 levels early in life is sufficient to accomplish lifelong Major-Minor division of labor in C. floridanus."

cell.com/cell/fulltext/S0092-8

@JonChevreau
heathercoxrichardson.substack.
Heather Richardson's analysis. Her conclusion: " It is astonishing that a major U.S. political party is considering either man to become the second in line for the presidency."

If you are in Switzerland on Jan 11 2024, join us for our symposium 'Cell Lines in the 21st Century': my.weezevent.com/cell-lines-in

We have a wonderful palette of speakers (see below).

@cyrilpedia hey that’s @meikeesther with a really great article. Sent it to everyone I know.

"This blog is highly biased on my n=1 experience. I am a Caucasian woman, married without children. I was asked about my marital status and the “moveability” of my husband at nearly all on-site interviews, and about children during half of them."

ecrlife.org/things-to-know-aca

Antoine Canat, Pierre Therizols and colleagues find that DAXX plays an essential role in the maintenance and 3D organisation of constitutive heterochromatin, which protects ESC viability.
Highlight: journals.biologists.com/jcs/ar
Article: journals.biologists.com/jcs/ar

Find out more about this research in our ‘First person’ interview with Antoine Canat: journals.biologists.com/jcs/ar

What is teleology today?

I've tripped over references to "teleology" from a 1968 paper and I'm trying to wrap my head around it. It's described as controversial, to say the least (CW: "teleology as a lady without whom no biologist can live without but he is ashamed to be seen with her in public." 🙄​). link.springer.com/chapter/10.1

Teleological explanations are defined as, "the explanation of phenomena in terms of the purpose they serve rather than of the cause by which they arise."

Do brain researchers use it today? For instance, are normative models (like Bayesian models of decision making) teleological? There, researchers typically define the optimal solution for a problem and compare real behavior to it.

What about the neuroconnectionist program? There, researchers typically define a problem that needs to be solved (like labeling objects in images), train an ANN to perform it, and compare that ANN to the brain.
nature.com/articles/s41583-023

The few papers I've found that discuss teleology versus Normativity were impenetrable. Thanks in advance for pointers in the right direction!

"A new report from Tufts Medical Center’s New Drug Development Paradigms (NEWDIGS) program shows that cell and gene therapies for orphan diseases and hematological cancers are two to 3.5 times more likely to be successful than other types of treatments for similar conditions, or as compared to the entire drug pipeline."

fiercebiotech.com/biotech/some

"She credits her postdoctoral research programme, the US National Institutes of Health’s institutional research and academic career development award (IRACDA), with teaching her about great mentorship."

nature.com/articles/d41586-023

"Educating doctors is a long and expensive process, but not every country can reward its graduates equally. Health spending per capita varies drastically in EU countries, from €816 per year in Romania to more than €4,000 in Luxembourg, Germany and other Western European countries. And so doctors and nurses follow the money."

politico.eu/article/doctors-nu

"Up to 18 children from the UK, Spain and the US are being recruited to the study, which aims to transform treatment of auditory neuropathy, a condition caused by the disruption of nerve impulses travelling from the inner ear to the brain."

ft.com/content/fc34dbe1-db03-4

Hardest hit by the exodus of doctors and nurses: the EU's newest members, plus crisis-hit Portugal and Greece, according to POLITICO's analysis of Commission data.

politico.eu/article/doctors-nu

Welcome to our new Editor, Renata Basto. Renata will handle papers focussing on the cell cycle, centrosomes, chromosomes, mitosis, genetic instability, mitotic spindle, microtubules, aneuploidy and polyploidy. If you have an article on one of these topics, consider sending it our way! bit.ly/45s0gwx

"Suddenly you become a public figure being asked to do all sorts of things: to give lectures, quite often on topics you know little about; to sit on committees and reviews you are not always well qualified to be on; to visit countries you have barely heard of; to sign endless petitions on what are probably good causes, but you never know. It is like having a whole new extra job, with upwards of 500 requests a year. It is impostor syndrome on steroids."

theguardian.com/commentisfree/

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