Thiago Carvalho @cyrilpedia@social.cleverlibre.org

"Their film is an intimate and righteous production that centers on Nicole Smith-Holt and James Holt, the Minnesota couple whose son Alec died mere months after turning 26 and being cut off from his parents’ health insurance."

https://www.theguardian.com/film/2023/oct/31/pay-or-die-documentary-insulin-price

"But back in 1857, when the idea of the dictionary was born, its three founders proposed something more democratic than authoritative: a reference book that didn’t prescribe but instead described English, tracking the meaning of every word in the language across time and laying out how people were actually using each one."

https://www.theatlantic.com/books/archive/2023/10/oxford-english-dictionary-sarah-ogilvie-book-review/675826/

A new episode of the EMBO podcast is out. I spoke with Hsiao-Han Chang, Gytis Dudas, and Hedvig Tamman about viruses, hosts, spillovers, public health... And also starting a new lab, the challenges of mobility, mentorship, and Die Hard Dracula.

#EMBOPodcast #scicomm #SciencePodcast #Virology
#Evolution #Microbiology

https://www.embo.org/podcasts/its-viruses-all-the-way-down-a-conversation-with-hsiao-han-chang-gytis-dudas-and-hedvig-tamman/

Deep immunological imprinting due to the ancestral spike in the current bivalent #COVID19vaccines @cellpress

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(23)00435-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2666379123004354%3Fshowall%3Dtrue

German geophysicist Alfred Wegener, who formulated the 1st complete statement of the continental drift hypothesis was born #OTD in 1880.

About 1910 he began toying with the idea that in the late Paleozoic Era all the present-day continents had formed a single large mass, or supercontinent, which had subsequently broken apart. He called this ancient continent Pangaea & he proposed that it's constituent portions had slowly moved thousands of miles apart over long periods of geologic time.

#Alphafold might be getting much better in ligand binding prediction https://deepmind.google/discover/blog/a-glimpse-of-the-next-generation-of-alphafold/ - sounds similar to #RoseTTAFold AA (#RFAA) https://www.biorxiv.org/content/10.1101/2023.10.09.561603v1 can't wait to get both on my hands... 😀 @strucbio #StructuralBiology

@halama_immuno @cyrilpedia thank you. Love the expression 'to be continued'! Should be final line of all our papers!

@gpollara @cyrilpedia Well...trials so far have shown: big toxicity, limited clinical effects and some suggest an increase in inhibitory Tregs...why there are modified IL-2 therapies around to limit toxic and Treg induction...to be continued #Immunotherapy #immunology #cytokines

@cyrilpedia an interesting idea, but personally, I think there's going to be way too small a therapeutic window to use IL-2 based therapies in a useful way. So ubiquitous and if it's function is so concentration dependent, then local tissue concentrations etc... will have big effect on function. Happy to be proved wrong!

Always boost/repost animal cognition breakthroughs, especially cephalopods!

From: @cyrilpedia
https://qoto.org/@cyrilpedia/111329215284092059

"Discussions around neurodivergence and neurodiversity have become more common over the past few years. However, this increased awareness has not necessarily led to better support and understanding."

https://elifesciences.org/inside-elife/44d04224/being-neurodivergent-in-academia-why-sparks-of-change-is-publishing-stories-from-neurodivergent-researchers

Thanks to the #EMERALD #MDPhD program students and the European MD/PhD Association for the invitation to speak at their "Finding the Creative Spark in Biomedical Research" conference at Centre for Genomic Regulation (CRG)/PRBB (Barcelona Biomedical Research Park).

When leaning becomes falling

"The tower, which, along with the Asinelli Tower, makes up the “two towers,” a symbol of the city, has historically slanted four degrees. But recent surveys have found traces of unexpected rotation in its incline and other imperceptible movements that need to be studied more carefully, the authorities said."

https://www.nytimes.com/2023/10/30/world/europe/italy-leaning-garisenda-tower-bologna.html

Happy Halloween! Here's a scary glia 👻🎃

'This is a central Laurencin paradox: She thrived in an art world that was almost entirely male by painting a world filled almost exclusively by women. When Laurencin pursued the French tradition of the 18th-century fête galante painting — pastoral scenes of courtship, flirtation and romantic intrigue epitomized by the work of Antoine Watteau — she excised all the men.'

https://www.nytimes.com/2023/10/25/style/marie-laurencin-barnes-foundation.html

Trains are in terrible shape, but yes let's all focus on TAP & airports

"A história tem vindo a ser relatada nas páginas do PÚBLICO: a linha ferroviária da Beira Alta, que se encontra encerrada desde Abril de 2022, permanecerá interrompida à circulação por “pelo menos mais seis meses”

https://www.publico.pt/2023/10/30/opiniao/opiniao/incuria-investimento-publico-2068413

"By his mid-20s, Mr. Holmes thought about what was ahead for him — sickle cell emergency after emergency, begging for help in Alabama hospitals that saw a Black man and assumed him to be a drug addict — and he started to think about ending his life. “Every time I tried anything, the disease would come and knock me away,” he remembered. “You get tired. You get worn out.”'

https://www.nytimes.com/2023/10/30/opinion/sickle-cell-gene-therapy-crispr.html

The #chemistry of #pumpkins. #halloween