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#IDMastodon #Immunology #Drugdevelopment Modulating #Eselectin/NLRP3 inflammasome/GSDMD-dependent activation pathway in #Neutrophils might therefore offer an interesting therapeutic approach for the treatment
of acute and chronic inflammatory disorders with unwanted neutrophil accumulation.
- S100A8/S100A9 is a proinflammatory mediator released by myeloid cells during many acute and chronic inflammatory disorders.

Postdoc.Mobility: fellowships for researchers after the doctorate who wish to gain more in-depth knowledge in their field and become more scientifically independent. The new call will be open until 1 February 2024.
snf.ch/en/UvraHFKsmICJXGYd/new

“We’re seeing the emergence of dengue in areas where we’ve never seen it before,” Adam Waickman, an immunologist at SUNY Upstate Medical University in Syracuse, New York, said during the meeting. “Effective dengue control is going to require multi-layered efforts.”

Particles of dengue virus (red; artificially coloured) infect a tissue specimen.
Image Credit: Science Source/SPL'

nature.com/articles/d41586-023

'Concerns over zoonotic diseases have greatly increased since the Sars-Cov-2 coronavirus emerged in China in late 2019 and spread swiftly across the globe. A study published by BMJ Global Health on Thursday found that environmental and population changes over the past six decades were driving growing numbers of such “spillover events” such as that which caused the coronavirus pandemic.'

ft.com/content/17c0ebb6-8391-4

Fully funded Doctoral (PhD) Positions at IMPRS- Biological Intelligence

Max Planck Institute for Biological Intelligence

Apply for your PhD at IMPRS-BI!
Application period: October 1st to November 15th.
Find out more: imprs-bi.mpg.de

See the full job description on jobRxiv: jobrxiv.org/job/max-planck-ins...
jobrxiv.org/job/max-planck-ins

As the great Groucho Marx said, “Those are my principles, and if you don't like them, I have others.”

'The EU is poised to water down a landmark piece of car pollution legislation after extensive lobbying from the automotive industry, which experts say will cause an estimated €100bn in health and environmental costs.'

theguardian.com/environment/20

"In a mouse model, neutralizing IL-10 signaling through antibodies, genetically ablating IL-10R1 in sensory neurons, or depleting monocytes with clodronate all impaired the resolution of pain hypersensitivity in both sexes."

biorxiv.org/content/10.1101/20

'In this illuminating study, he presents the outbreak of the revolution in Paris in 1789 as the culmination of 40 years’ worth of political scandals and cultural polemics, which — fueled by a barrage of real and fake news from a diverse range of sources — fostered in the public “a revolutionary temper that was ready to destroy one world and construct another.”

nytimes.com/2023/11/04/books/r

"Here, we describe an mRNA-based platform enabling delivery of pathogen-specific immunoglobulin A (IgA) monoclonal antibodies into mucosal secretions. The platform consists of synthetic mRNA encoding IgA heavy, light, and joining (J) chains, packaged in lipid nanoparticles (LNPs) that express glycosylated, dimeric IgA with functional activity in vitro and in vivo."

cell.com/cell-reports-medicine

"Uma startup de saúde ginecológica do Reino Unido lançou, recentemente, um tampão que funciona como um teste PCR para diagnóstico de doenças sexualmente transmissíveis (DST) nas mulheres. Segundo a empresa Daye, o tampão funciona como substituto do cotonete ou espéculo vaginal utilizados nos testes de rastreio e consegue igualmente identificar clamídia, gonorreia, microplasma, ureaplasma e tricomonas."

publico.pt/2023/11/06/p3/notic

It's going to take all the running in the world just to stand still.

"A machine-learning tool can easily spot when chemistry papers are written using the chatbot ChatGPT, according to a study published on 6 November in Cell Reports Physical Science1. The specialized classifier, which outperformed two existing artificial intelligence (AI) detectors, could help academic publishers to identify papers created by AI text generators."

nature.com/articles/d41586-023

Deflection of starlight by the Sun’s gravitational field, measured during a solar eclipse and confirming a central prediction of Einstein's general relativity, was announced at a joint meeting of the Royal Society and the Royal Astronomical Society #OTD in 1919.

This spider looks like an angry squirrel, and now I can't unsee it.

#Spiders

'Now the Centers for Disease Control and Prevention is reinforcing those findings via new research presented in October at the American Society of Tropical Medicine and Hygiene's conference, suggesting that a specific strain of the Leishmania parasite has likely been living in the U.S. for years.'

npr.org/sections/goatsandsoda/

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