Thiago Carvalho @cyrilpedia@social.cleverlibre.org

"More idiotic things may get done in the name of meeting year-end numerical goals than for any other reason in this industry, so thanks, but I'll try to ignore the recommendation to do them some more, but good and hard this time."

https://www.science.org/content/blog-post/andy-grove-rich-famous-smart-and-wrong

'Another implication of their study is that our ancestors enjoyed a malaria-free existence right up until the neolithic transition 10,000 years ago when, coincident with the shift from nomadic to agrarian lifestyles, Plasmodium falciparum, the parasite responsible for the deadliest form of human malaria, mutated to target Neu5Ac so abundantly present on human cells. It is thought that our more agricultural lifestyle made humans more vulnerable to the malaria-carrying mosquitoes that bred in stagnant pools near settlements.'

https://www.theguardian.com/science/2023/dec/10/sugar-coating-cells-illness-pathogens-evolutions-glycans-sialic-acids

"Después de una vida dedicada a la enseñanza, sobre todo en la provincia de Palencia, Ramiro Curieses, que ha sido maestro de infantil y primaria, docente y director en secundaria, y profesor asociado en la Universidad de Valladolid, está convencido de que una de las claves del buen resultado de las tres comunidades es la escuela rural, que las administraciones autonómicas y los Ayuntamientos protegen pese a su coste para intentar frenar la despoblación"

https://elpais.com/educacion/2023-12-10/el-triangulo-de-oro-de-la-educacion-en-espana-aqui-todo-el-mundo-tiene-claro-que-o-estudias-o-no-tienes-futuro.html

Today in Labor History December 10, 1865: August Spies, anarchist labor organizer and Haymarket martyr was born on this date. As he was led to the gallows (1887), he shouted, "The day will come when our silence will be more powerful than the voices you are throttling today." In 1883, he was a leader in the Revolutionary Congress, in Pittsburgh, that launched the International Working People's Association in America.

#WorkingClass #LaborHistory #anarchism #AugustSpies #haymarket #EightHourDay #execution #deathpenalty #prison #Revolution

We live in a country of widening inequalities and some of the decision making during peak Covid pandemic only added to it. I wrote this to show some of the questions I hope will be addressed tomorrow on the Covid enquiry https://open.substack.com/pub/sheenacruickshankimmunology/p/questions-for-rishi-sunak-and-the?r=11blfp&utm_medium=ios&utm_campaign=post

"Hoje justifica-se dizer que a esquerda portuguesa não está a prestar atenção à outra metade da lição das eleições espanholas, a saber: que foi possível extrair uma vitória por uma unha negra principalmente por causa da capacidade de cada partido progressista em mobilizar ou segurar o seu eleitorado, demonstrando capacidade de trabalhar em conjunto com os outros partidos progressistas no futuro."

https://leitor.expresso.pt/semanario/semanario2667/html/primeiro-caderno/opiniao/licoes-de-espanha-para-a-esquerda-portuguesa

"We therefore developed spatial transcriptomics for variable, diversity, and joining (VDJ) sequences (Spatial VDJ), which spatially resolves full-length IG and TR transcripts, tissue morphology, and the whole transcriptome simultaneously in human tissue."
#Immunology #Transcriptomics

https://www.science.org/doi/10.1126/science.adf8486

"A new study, published on Friday in the journal Science Advances, bolsters Williams’s theory using a trove of human DNA. Researchers found hundreds of mutations that could boost a young person’s fertility and that were linked to bodily damage later in life."

https://www.nytimes.com/2023/12/08/science/fertility-genes-lifespan.html

Let's mouth-pipette a toast to the good old days...

'It was Woese’s new approach to doing phylogeny that produced this completely unexpected and very newsworthy result. His method, which seems impossibly tedious now that we can sequence whole genomes over lunch, involved dangerous amounts of radioisotopes, highly flammable solvents, and weeks to months of effort to produce, for any cultured microbial species, an ‘oligonucleotide catalog’. '

https://www.cell.com/current-biology/fulltext/S0960-9822(15)00599-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0960982215005990%3Fshowall%3Dtrue

When cities run gun buyback programs, they pay a vendor to run the program and destroy the guns. Despite their marketing to the contrary, those vendors turn out to have been reselling the guns, as a matter of course, minus the receiver. 98% are resold. https://www.nytimes.com/2023/12/10/us/guns-disposal-recycling.html?unlocked_article_code=1.E00.JnYH.TqkHjf6uP1oW&smid=nytcore-ios-share&referringSource=articleShare

The foulishness cult, I see...

Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA polymerase III assembly https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00908-5?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

Pliosaur discovery: Huge sea monster emerges from Dorset cliffs https://www.bbc.com/news/science-environment-67650247

#science

PhD Researcher (f/m/x) - Developing a bioelectrochemical process for degrad

Helmholtz Centre for Environmental Research (UFZ)

See the full job description on jobRxiv: https://jobrxiv.org/job/helmholtz-centre-for-environmental-research-ufz-27778-phd-researcher-f-m-x-developing-a-bioelectrochemical-process-for-degrad/?feed_id=674...
https://jobrxiv.org/job/helmholtz-centre-for-environmental-research-ufz-27778-phd-researcher-f-m-x-developing-a-bioelectrochemical-process-for-degrad/?feed_id=67487

December 10, 1823, Mary Anning finds the first complete Plesiosaur skeleton.
She sketched her discovery in one of her letters - the #animal's anatomy was so unusual, at first nobody believed her 🎧🐉

https://futilitycloset.com/2018/06/11/podcast-episode-204-mary-annings-fossils/

December 10, 1964, Dorothy Hodgkin is the first British woman to be awarded the #NobelPrize in #Chemistry for her work on the structure of penicillin and vitamin B12 - here seen in its crystalline form 💎

https://en.wikipedia.org/wiki/Dorothy_Hodgkin