Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'The Portuguese singer, songwriter and guitarist Sara Tavares in 2018. “It will be a long time,” she once said, “before the people from my generation do not have to choose between being African or European.”
Credit: Sipa, via Associated Press
https://www.nytimes.com/2023/12/12/arts/music/sara-tavares-dead.html
"The bulk of 2023’s retractions were from journals owned by Hindawi, a London-based subsidiary of the publisher Wiley (see ‘A bumper year for retractions’). So far this year, Hindawi journals have pulled more than 8,000 articles, citing factors such as “concerns that the peer review process has been compromised” and “systematic manipulation of the publication and peer-review process”, after investigations prompted by internal editors and by research-integrity sleuths who raised questions about incoherent text and irrelevant references in thousands of papers."
"The tradition of extended families living together in multistorey buildings, compounded by relatives moving in together for safety in wartime, has meant that hundreds of multigenerational families have suffered the same fate as the Aghas, all but wiped out in single or multiple strikes."
https://www.ft.com/content/c09cc412-ae5c-423e-8e1d-b888d9f65598
Thiago Carvalho
boosted
Immunopeptidomics in the Era of Single-Cell Proteomics https://www.mdpi.com/2079-7737/12/12/1514
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#proteomics #prot-paper
Thiago Carvalho
boosted
Gene therapy offered this 7-year-old freedom. The price: a grueling year
'Recentemente, foi divulgado um estudo (O Futuro da Ciência e da Universidade, por Maria de Lurdes Rodrigues e Jorge Rodrigues da Costa, Edições Almedina) que indica que o investimento público em investigação e desenvolvimento (I&D) está hoje abaixo do que era em 1991, sendo de apenas 0,32% do PIB (menos de metade da média da OCDE).'
https://www.publico.pt/2023/12/13/ciencia/opiniao/futuro-ciencia-portugal-2073279
Thiago Carvalho
boosted
Combining STING & TLR9 pathway agonists:
"The aim of this study was to develop a highly immunogenic vaccine using pattern recognition receptor agonists in combination with synthetic long peptides to induce potent neoantigen-specific T cell responses. We determined that the combination of the TLR9 agonist K-type CpG oligodeoxynucleotides (K3 CpG) with the STING agonist c-di-AMP (K3/c-di-AMP combination) significantly increased dendritic cell activation."
#Immunology #Immunotherapy #Vaccines
Thiago Carvalho
boosted
Method
"Robert De Niro was suggested by the producer, Arnon Milchan – it turned out Bobby was a big Python fan. Though his character, Tuttle, is a relatively small part, he’s the hero really, as he’s the only person who’s achieving anything. I said to him: “You’re a plumber, but I want you to treat the plumbing like it’s brain surgery.” He actually found a New York neurosurgeon and sat in on an operation as part of his preparation, though when you see Tuttle handling equipment in closeup, those hands are mine."
Thiago Carvalho
boosted
PhD student in Evolutionary Genetics
University of Tartu, Institute of Genomics
@genomicstartu is looking for a motivated PhD student with a background in archaeology, genetics, medical genomics, statistics and/or bioinformatics
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-tartu-institute-of-genomics-27778-phd-student-in-evolutionary...
https://jobrxiv.org/job/university-of-tartu-institute-of-genomics-27778-phd-student-in-evolutionary-genetics/?feed_id=67746
Thiago Carvalho
boosted
Transcriptomics and Spatial Proteomics for Discovery and Validation of Missing Proteins in the Human Ovary https://pubs.acs.org/doi/10.1021/acs.jproteome.3c00545
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#proteomics #prot-paper
'An artist’s rendering of a young Gorgosaurus eating a small, feathered dinosaur called Citipes. The prey animal was consumed during the last week of the Gorgosaurus’s life. Credit: Julius Csotonyi/Royal Tyrrell Museum'
https://www.nytimes.com/2023/12/08/science/tyrannosaur-last-meal-gorgosaurus.html
Thiago Carvalho
boosted
Med student, 27, diagnoses own breast cancer with patient chart after doctor withheld results
Thiago Carvalho
boosted
"I wrote about long Covid in June 2020. In the following days, I got more than 100 emails from people who thought they were going mad — or had been told as much — and felt validated to see their reality reflected. That story was the first of an octet; those responses were the vanguards of thousands more."
#Covid #covid19 #LongCovid
Thiago Carvalho
boosted
"The Anglo-Swedish drugmaker (AstraZeneca) said on Tuesday that it had struck a deal for Seattle-based Icosavax, which has a potential vaccine for two common respiratory diseases that can cause severe illness in older adults: respiratory syncytial virus (RSV) and human metapneumovirus."
https://www.ft.com/content/1ededcba-dd40-455e-8fe0-fc3084389184
Thiago Carvalho
boosted
Thiago Carvalho
boosted
Domestic cats eat more than 2000 species including turtles and insects https://www.newscientist.com/article/2408124-domestic-cats-eat-more-than-2000-species-including-turtles-and-insects/
Thiago Carvalho
boosted
Heads up to folks in the US seeking abortions or gender-affirming care in an increasingly criminalized environment: pharmacies share medical data with police without a warrant because of course they do.
https://www.washingtonpost.com/technology/2023/12/12/pharmacy-records-police-privacy-abortion/
Method
"Robert De Niro was suggested by the producer, Arnon Milchan – it turned out Bobby was a big Python fan. Though his character, Tuttle, is a relatively small part, he’s the hero really, as he’s the only person who’s achieving anything. I said to him: “You’re a plumber, but I want you to treat the plumbing like it’s brain surgery.” He actually found a New York neurosurgeon and sat in on an operation as part of his preparation, though when you see Tuttle handling equipment in closeup, those hands are mine."
Thiago Carvalho
boosted
How do #bacteria sense repellents? @zhulinlab show that although the #attractant citrate & the #repellent malate bind to the same site in the receptor ligand-binding domain of a #chemoreceptor, they induce different conformational changes #PLOSBiology https://plos.io/47Teus6
Thiago Carvalho
boosted
STAT+: Pharmalittle: Sanofi scraps rare-disease drug deal under FTC pressure; patients regain weight after stopping Lilly's Zepbound
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
