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'Las protestas contra las condiciones en las que trabajan los moderadores, encargados de que a su móvil no llegue (más) contenido tóxico y extremadamente violento, han llegado hasta los juzgados en países como Kenia, donde 184 africanos pelean desde hace meses en los tribunales contra Meta (empresa matriz de Facebook, Instagram y WhatsApp). Exigen 1.600 millones de euros como compensación por ser despedidos en enero de este año, tras quejarse de sus condiciones de trabajo y del daño a su salud mental y tratar de montar un sindicato.'

elpais.com/planeta-futuro/2023

'AI, through its inhuman ability to process and find connections between huge quantities of data, is also obfuscating how these breakthroughs happen, by producing results without explanation. Unlike human researchers, the technology tends not to show its work—a curious development for the scientific method that calls into question the meaning of knowledge itself.'

theatlantic.com/newsletters/ar

Finally got to know I3S Porto! A discussion of scientific publication & communication during the first year of the pandemic that could have gone on much longer. Thanks to Perpetua Pinto-do-Ó & Margarida Saraiva for the invitation.

'AI, through its inhuman ability to process and find connections between huge quantities of data, is also obfuscating how these breakthroughs happen, by producing results without explanation. Unlike human researchers, the technology tends not to show its work—a curious development for the scientific method that calls into question the meaning of knowledge itself.'

theatlantic.com/newsletters/ar

'Las protestas contra las condiciones en las que trabajan los moderadores, encargados de que a su móvil no llegue (más) contenido tóxico y extremadamente violento, han llegado hasta los juzgados en países como Kenia, donde 184 africanos pelean desde hace meses en los tribunales contra Meta (empresa matriz de Facebook, Instagram y WhatsApp). Exigen 1.600 millones de euros como compensación por ser despedidos en enero de este año, tras quejarse de sus condiciones de trabajo y del daño a su salud mental y tratar de montar un sindicato.'

elpais.com/planeta-futuro/2023

@cyrilpedia @medrxivpreprint precisely - and this is backed up by registry data that has never shown a signal for TB reactivation with tocilizumab etc.... unlike for TNF inhibitors. Redundancy at best in this pathway, and too much IL-6 may even be bad!

"Lunch—dinner, drinks, any occasion—with Christopher always was. One of our lunches, at Café Milano, the Rick’s Café of Washington, began at 1 p.m., and ended at 11:30 p.m.At about nine o’clock (though my memory is somewhat hazy), he said, “Should we order more food?” I somehow crawled home, where I remained under medical supervision for several weeks, packed in ice with a morphine drip. Christopher probably went home that night and wrote a biography of Orwell. His stamina was as epic as his erudition and wit."
(Via The Browser)

newyorker.com/news/news-desk/p

"E, com o passar do tempo, a corrupção institucionalizada e legal com dinheiros europeus passou mesmo a ser a principal forma de a Comissão Europeia e o Conselho Europeu lidarem com Orbán. Precisas do meu voto? Dá cá uns milhares de milhões."

@ruitavares

leitor.expresso.pt/semanario/s

@medrxivpreprint v cool - thanks for sharing @cyrilpedia - we have a stake in this IL-6 game. Actually, with knowledge of this area and pathway, I'm not that surprised to see this result. Consistent with many other chronic inflammatory / autoimmune conditions. (and #TB too! medrxiv.org/content/10.1101/20) #immunology

Pay attention. Learn from history. Don’t let this man anywhere near the White House ever again.

"Here we show that hypoxia results in reversible entry into the cell cycle in monocyte derived macrophages (MDM) and mouse peritoneal macrophages. Cell cycle progression is largely limited to G1/S phase with very little progression to G2/M."

biorxiv.org/content/10.1101/20

"Spatial transcriptomics revealed that liver abscesses are associated with heterogenous immune cell clusters comprised of macrophages, neutrophils, dendritic cells, innate lymphoid cells, and T-cells that surround necrotic regions of the liver."

pnas.org/doi/10.1073/pnas.2310

It was great to be back at the IGC on Friday. I'm going to miss it.

Genetic evidence for efficacy of targeting IL-2, IL-6, and TYK2 signaling in prevention of type 1 diabetes: A Mendelian randomization study medrxiv.org/content/10.1101/20

RNA vax for RSV

"Vaccine efficacy was 83.7% (95.88% confidence interval [CI], 66.0 to 92.2) against RSV-associated lower respiratory tract disease with at least two signs or symptoms and 82.4% (96.36% CI, 34.8 to 95.3) against the disease with at least three signs or symptoms."

nejm.org/doi/full/10.1056/NEJM

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