Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"This year, countries with a combined population of 4 billion — around half the world’s people — are holding elections, in what is being described as the biggest election year in recorded history. Some researchers are concerned that 2024 could also be one of the biggest years for the spreading of misinformation and disinformation."
Thiago Carvalho
boosted
Pangenome reconstruction in rats enhances genotype-phenotype mapping and novel variant discovery https://www.biorxiv.org/content/10.1101/2024.01.10.575041v1?med=mas
Thiago Carvalho
boosted
Don't fall for the "future of finance" messaging.
And don't believe the influencers.
Within the cryptocurrency sphere, the buzz surrounding Bitcoin ETFs is entirely fueled by the "greater fool" theory, a market principle suggesting that the value of an asset is determined not by its intrinsic value but by the collective belief that someone else will pay more for it in the future.
https://joanwestenberg.com/blog/bitcoin-etfs-will-make-greater-fools-of-us-all
"A painter is like the pilot of a small boat—constantly correcting course, ever alert to changes in the weather, trying not to get swamped by the wakes of larger boats, steering toward the distant shore. A lifetime of painting requires more than just will; agility of mind helps. “Alex Katz: Gathering,” the artist’s long-awaited retrospective at the Guggenheim Museum, was both Olympian in scale and outlook and a hard-charging athletic event, sweeping in scope yet light on its feet."
https://www.nybooks.com/articles/2024/01/18/follow-the-light-alex-katz-gathering/
Thiago Carvalho
boosted
It's been well over a year, but I still haven't fully processed that I am co-author of a theory paper suggesting that "psychedelics are analogous to cognitive laxatives."
And this happened in part via a question I asked during a journal club!
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awac256/6648879
Thiago Carvalho
boosted
"Substack’s argument in response to the Atlantic article was a masterclass in how not to do it: the best way to defeat these ideas, it claimed, was through scrutiny. Frankly, if scrutiny was going to defeat neo-Nazis or the idea that the Cultural Revolution had some upsides, it would have done so already."
https://www.ft.com/content/648ec2c0-d71b-4dc6-af15-56fedc54eb2d
Thiago Carvalho
boosted
"Scientists found the thickly contextualised, sharply focused histories of now-discarded science irrelevant and indigestible. Historians bridled at the scientists’ demands for a mythologised and anachronistic version of the past. We think it’s time to restart the conversation, for the benefit of both scientists and historians."
https://aeon.co/essays/science-and-history-cannot-afford-to-be-indifferent-to-each-other
"lthough not observed in mouse ILC2s, we found that human ILC2s secrete granzyme B (GZMB) and directly lyse tumor cells by inducing pyroptosis and/or apoptosis, which is governed by a DNAM-1−CD112/CD155 interaction that inactivates the negative regulator FOXO1."
#Immunology
https://www.cell.com/cell/fulltext/S0092-8674(23)01347-8?rss=yes
"In 1988, physician scientists discovered LINE-1 insertional mutations in the blood-clotting gene factor VIII in two unrelated individuals with hemophilia, providing the foundation that LINE-1 is an active mobile element in humans (Kazazian et al. 1988). In the 35 yr since this landmark discovery, >100 LINE-1-mediated insertional mutations resulting from germline retrotransposition have been shown to cause human genetic diseases (Hancks and Kazazian 2016). In each example, LINE-1 activity inserted a retrotransposon sequence at a critical gene sequence and caused a loss-of-function allele."
Thiago Carvalho
boosted
Addgene is stopping all activity on Twitter/X
"However, IL-2’s effectiveness is hindered by its pleiotropic nature, because its receptor is found on various immune cells, including regulatory T (Treg) cells and natural killer (NK) cells, which can counteract antiviral responses or contribute to toxicity, respectively. To address this, we developed a cis-targeted CD8-IL2 fusion protein, aiming to selectively stimulate dysfunctional CD8+ T cells in chronic HBV. In a mouse model, CD8-IL2 boosted the number of HBV-reactive CD8+ T cells in the liver without substantially altering Treg or NK cell counts."
#Immunology
Thiago Carvalho
boosted
Satellite maps reveal rampant fishing by untracked "dark vessels" in the world’s oceans.
@Smithsonianmag reports: "Using satellite imagery and A.I., a new study finds about 75 percent of industrial fishing is not publicly tracked, and clandestine ships enter marine protected areas."
'Health officials in Brazil have warned that the number of dengue cases in the country could hit a record 5mn this year as climate change and the El Niño weather pattern in the Pacific Ocean fuel the spread of mosquito-borne diseases.'
#Dengue
https://www.ft.com/content/2f3b9b80-7b9a-42d4-bf7f-ea8492a8da24
Thiago Carvalho
boosted
Online now: Why incorporate plant architecture into trait-based ecology? https://www.cell.com/trends/ecology-evolution/fulltext/S0169-5347(23)00328-2?rss=yes&utm_source=dlvr.it&utm_medium=mastodon
Thiago Carvalho
boosted
'Nos termos do “acordo de atribuição de patentes e licenciamento”, a BioNTech – que desenvolveu uma das vacinas contra a covid-19 com base na tecnologia de ARN-mensageiro (mRNA) – adquiriu igualmente a “tecnologia adicional ADC (antibody-drug conjugate)”.
Thiago Carvalho
boosted
Relief etching on copper by @madparreira.bsky.social
#printmaking #etching #print #copper #art #artgallery #handmade
Thiago Carvalho
boosted
Today marks the anniversary for when insulin was used to treat diabetes for the first time, in 1922. The insulin was given to a Canadian 14 year old boy, Leonard Thompson, with Type diabetes. It was administered by Frederick Grant Banting, a Canadian medical physician. Aided by the treatment, Thompson went on to survive another 13 years. He died at the age of 27 from pneumonia. Prior to the clinical development of insulin, Type 1 diabetes was a fatal disease.
Thiago Carvalho
boosted
🌼🍈Join us to learn about the newly published paper ‘Developmental stages and episode-specific regulatory genes in andromonoecious melon flower development’ in @AnnBot by Giuliano Pechar and co-authors. (1/7)
👉 https://botany.fyi/DhuV1c #AoBpapers
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
