"We had done one heart transplant during my rotating internship in Nigeria. He was a kid with rheumatic heart disease, and it was the first cardiac transplant in Nigeria. I was on that service; I worked hard but unfortunately the patient died and I kept thinking it was a futile exercise. If the child had had penicillin, he would never have damaged his heart — that got me thinking about prevention. Those were moments that were transformative for me in thinking about how I wanted to spend the rest of my life as a doctor."
'Those customers are both on the author side and the editorial side. You too can be a co-author if you just pony up, and if you're an editor, well, you can earn extra cash by slotting these papers into the journal. An especially good route to that has been the "Special Issue" racket, where a group of themed papers are rounded up by a guest editor'
https://www.science.org/content/blog-post/just-bribe-everyone-it-s-only-scientific-record
When people first came to Australia 65,000 years ago, the Earth was in an ice age. Then the seas rose, drought and floods came – and still people endured.
https://theconversation.com/ecology-on-steroids-how-australias-first-nations-managed-australias-ecosystems-214854?utm_term=Autofeed&utm_medium=Social&utm_source=Facebook#Echobox=1705646011
The telomeric lncRNA known as #TERRA is no longer “non coding”! Jack Griffith and colleagues 👏 found out that #telomeres are actually translated into val-arg and gly-leu repeat peptides! This is most unexpected without a possible function in sight! Amazing! 😳 https://www.pnas.org/doi/10.1073/pnas.2221529120
'The last time the Northern Illinois Brood’s 17-year cycle aligned with the Great Southern Brood’s 13-year period, Thomas Jefferson was president. After this spring, it’ll be another 221 years before the broods, which are geographically adjacent, appear together again.'
https://www.nytimes.com/2024/01/19/science/cicadas-emergence-broods.html
'Here, we review our present understanding of the various pathways to cell death. The literature is extensive and, at times, confusing and even contradictory. As such, at the risk of missing certain advances, we have chosen to emphasize concepts that have been pressure-tested through a combination of biochemistry and genetics and are therefore likely to stand the test of time.'
'This was Coppola’s bid to take his place among the cinema’s image-masters, such as F. W. Murnau and King Vidor, who took bare-bones stories of an abstracted simplicity—at the edge of legend—and endowed them with overwhelming power through sheer visual impact.'
'The microscope revealed an eerie landscape of destruction. All that was left in the patient’s cortex were astrocytes and microglia, and the few remaining neurons showed extensive vacuolation of their bodies and processes. Such blazing destruction of the brain was indicative of just one diagnosis: Creutzfeldt-Jakob disease, a spongiform encephalopathy caused by enigmatic infectious agents called prions.'
Judd Legum weighs on the filthy racist meme developing in right-wing circles now, which blames "diversity" on the Boeing incident in which a door popped off a plane in flight:
"The overwhelming majority of C-Suite executives at both companies are white men. Boeing’s CEO, CFO, Chief Compliance Officer, and Chief Aerospace Safety Officer are all white men."
''The neurons derive from mathematical models of biological neurons originally formulated by Warren S. McCulloch and Walter Pitts, in a landmark 1943 paper, titled “A Logical Calculus of the Ideas Immanent in Nervous Activity.” McCulloch and Pitts argued that brain activity could be reduced to a model of simple, interconnected processing units, receiving and sending zeros and ones among themselves based on relatively simple rules of activation and deactivation.
https://www.newyorker.com/culture/annals-of-inquiry/how-much-of-the-world-is-it-possible-to-model
For #FindsFriday a gorgeous object: the Mannetje van Willemstad (the little man from Willemstad, Netherlands) aka The Oldest #Smile in the world. The #Mesolithic figurine, dating about 5,400 BC, was carved in oak wood. Its purpose isn't clear: Ritual? A doll?
Height 12.5 cm. On display at RMO Leiden.
Big news in bug math. This is the first year since 1803 when both 13-year cicadas and 17-year cicadas will emerge from the ground simultaneously in the US!
13 and 17 are both prime. It's believed cicadas evolved to have prime-number life cycles to avoid predators that emerge more frequently, like once every 4 years or 5 years or... whatever. By showing up infrequently, with a prime number life cycle, they can starve out those predators.
And since 13 and 17 are both prime and 13 × 17 = 221, both kinds of cicadas emerge simultaneously only once every 221 years. And
1803 + 221 = 2024
so now they'll both emerge simultaneously and we'll have 𝑙𝑜𝑡𝑠 of cicadas!
Also, this year the two kinds can interbreed!
The last time the Northern Illinois Brood’s 17-year cycle aligned with the Great Southern Brood’s 13-year cycle, Thomas Jefferson was president.
https://www.nytimes.com/2024/01/19/science/cicadas-emergence-broods.html
"But where the drop in severe-COVID incidence is clear and prominent, the drop in long-COVID cases is neither as certain nor as significant. Plenty of new cases of the chronic condition are still appearing with each passing wave—even as millions of people who developed it in years past continue to suffer its long-term effects."
https://www.theatlantic.com/health/archive/2024/01/long-covid-dropping-risk-incidence/677183/
'Now, as Adam Shatz tells us in this insightful biography, Fanon is even more of an icon for the left — thanks partly to the force of his writing, with “its mood of revolt, protest and insubordination”. If you want to know what makes today’s radicals tick, from demands for “decolonisation” in museums and universities, to Black Lives Matter, then Fanon is a good place to start.'
https://www.ft.com/content/8e94438a-c89c-495a-9123-9eb860123fa6
'The evidence is plain to see. A woman dies somewhere in the world every two minutes during pregnancy or childbirth, and each day more than 6,000 neonatal babies die within their first four weeks of life. This unacceptable death toll is especially high in sub-Saharan Africa.'
https://www.ft.com/content/35ce3cff-7579-4784-8af6-16ba7fd54d14
CD4+ T cell immunity against cutaneous melanoma encompasses multifaceted MHC II–dependent responses
'The UK is falling behind the EU on almost every area of environmental regulation, as the bloc strengthens its legislation while the UK weakens it. In some cases, ministers are removing EU-derived environmental protections from the statute book entirely.'
#OTD 19 January 1839 Paul Cézanne was born. Cézanne is said to have formed the bridge between late 19th-century Impressionism and the early 20th century's new line of artistic enquiry, Cubism.
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com