Thiago Carvalho @cyrilpedia@social.cleverlibre.org

'The present study illustrates great potentials of chimeric antigen receptor (CAR-T) cells targeting B cell maturation antigen in treating anti-signal recognition particle myopathy, with sustained depletion of autoantibodies and therapeutic efficacies beyond 18 mo.'
#immunotherapy #CARTcells

https://www.pnas.org/doi/10.1073/pnas.2315990121

'The Shanahan Foundation Fellowship at the Interface of Data and Neuroscience was created to provide freedom and flexibility to promising young scientists from diverse fields, as they work alongside neuroscientists at the Allen Institute and University of Washington. The three-year fellowship provides Ph.D.s from data science, computer science, physics, mathematics, and many other fields the mentorship and support to pursue their own research interests with our data.'

https://alleninstitute.org/careers/internships-and-postbac/shanahan-foundation-fellowship/

'There are lots of lurid tales about the Wa, who once made a practice of beheading intruders. But the book’s bigger story involves America’s hapless war on drugs. Winn spent several years interviewing Wa citizens, U.S. Drug Enforcement Agency lifers and CIA spies. He learned that Wa-produced heroin found its way to American soldiers in Vietnam, and in the years that followed, CIA-linked opportunists helped the Wa become a force in Southeast Asia’s meth trade.'

https://crimereads.com/patrick-winn-narcotopia-wa-state/

'The Duchess was a vanishingly rare creature: a self-taught natural philosopher writing in the decades when natural philosophy was developing into what we now call science, a professionalized field that would embrace the new disciplines of astronomy, geography, mathematics, and physics. She also belonged to an emergent species: the female intellectual.'

https://www.newyorker.com/magazine/2024/02/05/pure-wit-the-revolutionary-life-of-margaret-cavendish-francesca-peacock-book-review

Is this "the first human-made textbook"?

Huge drawing of touchable animal tracks would be an ideal teaching tool for young hunters & trackers.

Some of the carvings are in a narrow crevice, almost like it was a "test" where the student could move through the prints identifying them by touch. (that's my guess for how they used it)

Some of the prints are from animals who no longer live in the region.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0289560

How does the microbiome shape host physiology?

New study provides evidence that certain groups within the fly microbiome have critical functions for host development.

#ReviewedPreprint with public reviews by @eLife.

https://sciety.org/articles/activity/10.1101/2023.08.01.551563?utm_source=mastodon&utm_medium=social&utm_campaign=sci_mastodon_2023_163

A late #ADHD diagnosis helped Tigist Tamir find the strategies and coping skills she needed to do research while preserving her mental health.

She shares her story and six tactics that worked for her in #SparksOfChange 15/n https://elifesciences.org/articles/95068?utm_source=mastodon&utm_medium=social&utm_campaign=organi_features

Antibody-mediated protein degradation is a cool method to eliminate proteins that e.g. behave badly in disease. This new method PACTAC uses PCSK9-antibody fusions to target receptors for lysosomal degradation.

https://www.embopress.org/doi/full/10.1038/s44319-024-00063-3

#CellBiology #Biochemistry

not for the first time I've been part of a team doing the southern-most direct ocean observations on the planet... we have just emerged from the Bay of Whales (yes there were #whales). Its where #Amundsen took #Fram and set up base for his successful round trip to the pole. It was also mind-meltingly spectacular. We got to around 78o 40'S and took a temperature-salinity profile. Why wouldn't you do all you can to preserve this planet?

The deadline for the next JEB Travelling Fellowship applications is this Friday 2 February, so make sure you don't miss out on this great opportunity

To find out more, go to https://biologists.com/travelling-fellowships/

Tracks.

📖 What is #OpenScience for? Introducing the Heliocentric Model of Open Science Documentation

📅 5 February, 4 PM – Online

🎤 Speaker: Monica Gonzalez-Marquez, Forschungszentrum Jülich

➡ Register for the Zoom Meeting (includes discussion part): www.nfdi.de/talks
➡ Join the YouTube stream: https://www.youtube.com/watch?v=gIS59CknqFo

#fdm #NFDI #forschungsdaten #data

Biological rhythms have been broadly ignored in #ecotoxicology.

@michaelgbertram &co highlight the importance of biological rhythms for understanding, predicting, and mitigating the complex ecological repercussions of chemical #pollution.

https://plos.io/49gwU6E

Irving Langmuir American physical chemist who was awarded the 1932 Nobel Prize for Chemistry was born #OTD in 1881.

Besides surface chemistry, his scientific research, spanning more than 50 years, included chemical reactions, thermal effects, and electrical discharges in gases; atomic structure; surface phenomena in a vacuum; and atmospheric science.

https://en.wikipedia.org/wiki/Irving_Langmuir

#science #chemistry #physics

French lawmakers vote to enshrine abortion in constitution

> France's lower house of parliament, the National Assembly, on Tuesday overwhelmingly approved a bill that would enshrine a woman's right to an abortion in the French Constitution.
https://www.dw.com/en/french-lawmakers-vote-to-enshrine-abortion-in-constitution/a-68127309 #France #abortion #womensrights #abortionrights

"Fixation on a narrow idea of success often leads to burnout, mental-health issues and the abandonment of promising careers." https://www.nature.com/articles/d41586-024-00239-w