Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"Chama-se Gene T e o nome dá já pistas sobre a área em que o novo centro de investigação da Universidade de Coimbra se irá focar: a terapia genética. Com um financiamento de 38 milhões de euros provenientes de investimentos europeus e nacionais, ao longo de seis anos, este será, aliás, o primeiro centro de investigação dedicado à terapia genética do país, cujo objectivo passa por desenvolver terapias inovadoras para doenças graves e sem tratamento, em particular para as doenças raras e de origem genética."
Thiago Carvalho
boosted
Tbx1 haploinsufficiency causes brain metabolic and behavioral anomalies in adult mice which are corrected by vitamin B12 treatment https://www.biorxiv.org/content/10.1101/2024.02.01.578212v1?med=mas
"Não é preciso apresentar argumentos para afirmar que se trata de uma ação ilícita de natureza racista e xenófoba e que consistirá em puro incitamento ao ódio e à violência contra pessoas em razão da sua cor, nacionalidade, ascendência ou religião. Cada um de nós sabe exatamente do que se trata."
"Infections are the second-leading cause of death among cancer patients, and lead to one in five being hospitalised during treatment. Given that many cancer therapies weaken the immune system, making patients more susceptible to infections, this is to some extent to be expected. But increasingly clinicians see infections that are becoming drug-resistant — antibiotics once effective against them no longer work. Without new and effective antibiotics, this is only going to get worse, with more people surviving cancer only to die of an infection that was previously treatable."
https://www.ft.com/content/196fc183-cd54-461c-a3dc-215bfbcd90fa
Thiago Carvalho
boosted
Ultra-fast label-free quantification and comprehensive proteome coverage with narrow-window data-independent acquisition - Nature Biotechnology https://www.nature.com/articles/s41587-023-02099-7
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#proteomics #prot-paper
I wish I could see this:
"Here, at this particular moment, means a rather spartan meeting room in the Almeida Theatre’s north London rehearsal rooms. The American actor, loved by many as the wise detective Lester Freamon in HBO’s The Wire and now 71, is taking a break from working on one of Shakespeare’s most enigmatic characters: the Fool in King Lear."
https://www.ft.com/content/59f78daa-78ca-4400-aebc-fd1239324823
Thiago Carvalho
boosted
Optogenetic mapping of rhythmic phase-dependentexcitability in the mouse striatum https://www.biorxiv.org/content/10.1101/2024.02.01.578473v1?med=mas
Thiago Carvalho
boosted
Now that there are no special covid protocols in place (other than we should try and avoid getting it and spreading it, use vaccines, masks & self-isolation), why is there all that track and trace stuff still installed and active on my phone? I mean, nobody is notifying / reporting covid infections any more than they would flu or even a common cold, so all that tracking & contact tracing is being used for what, exactly?
Thiago Carvalho
boosted
Everybody I’ve seen promote the use of LLMs for writing seems to misunderstand everything about the process of writing
To pick one example: the point of first drafts isn’t to spew out a conventional structure that you then tweak, filled with generic writing that you then make personal
It’s to capture the weird, the spontant, and the disjointed but strangely appropriate
The first draft is there to lay down your raw humanity on the page, that you then polish into something comprehensible
'Almost a decade ago, Howard Chang, a dermatologist and molecular geneticist at Stanford University School of Medicine in California and a co-author of the current study, noticed that many of the proteins that interact with XIST were targets of misguided immune molecules called autoantibodies.'
#Immunology #autoimmunity #autoimmunedisease
"Over a 3-year enrollment period, 16,235 participants received either Butantan-DV (10,259 participants) or placebo (5976 participants). The overall 2-year vaccine efficacy was 79.6% (95% confidence interval [CI], 70.0 to 86.3) — 73.6% (95% CI, 57.6 to 83.7) among participants with no evidence of previous dengue exposure and 89.2% (95% CI, 77.6 to 95.6) among those with a history of exposure."
#Dengue #Vaccine #Immunology
'Extreme weather events due to climate change are increasingly affecting production: some water reservoirs in southern Spain stand at only 4% capacity, while wildfires wiped out about 20% of Greek annual farm revenue last year.'
Thiago Carvalho
boosted
"Metastatic cancers (those that have spread beyond the organ where they originated) account for around 67–90% of cancer deaths2,3, and are almost always treated systemically, meaning with drugs that enter the bloodstream. To improve treatments for people with metastatic cancer, the community urgently needs to shift from using organ-based classifications of cancer to using molecular-based ones. This will require radical changes in how medical oncology is structured, conducted and taught."
Thiago Carvalho
boosted
'Scientists are among those most trusted by the survey’s respondents to tell the truth about innovations and new technologies, with 74% of respondents saying they trust scientists to tell the truth. A similar proportion said that they wanted the introduction of innovations to be led by scientists. By comparison, just 47% of respondents said that they trusted journalists and 45% trusted government leaders to tell the truth on innovations.'
Thiago Carvalho
boosted
"With the rise of year-end reading goals on sites like Goodreads, even those of us who actually like to read can get caught up in the commodification of reading, where productivity must increase year over year. Optimization and efficiency leave very little room for meandering walks with great big books that require deep thought and engagement. And I don’t know about you but that’s what I love about literature the most."
https://lithub.com/against-disruption-on-the-bulletpointization-of-books/
Thiago Carvalho
boosted
David del Alamo & I have spent the last 18 months putting our combined experience in scientific editing, education & funding into this baby. We've been running workshops since last January & now we've launched our site 👇
Thiago Carvalho
boosted
It is February for academics, when all January deadlines are gone, and new extensions are offered to manuscripts due in 2023, and a slight panic starts to settle in.
Look at the annoyed and bored face of Jerome while writing, and enjoy this fancy book wheel.
Bonus: his lion does not approve you working too much. #academicchatter
Thiago Carvalho
boosted
Cell-material interactions in 3D bioprinted plant cells https://www.biorxiv.org/content/10.1101/2024.01.30.578043v1?med=mas
Thiago Carvalho
boosted
Thiago Carvalho
boosted
RT by @joseggusmao: A direita privatizou a EDP, a maioria PS deu-lhe uma borla fiscal, os acionistas ganharam, o país perdeu. Isto é o liberalismo a funcionar. As privatizações são a corrupção da economia, a entrega do que é nosso aos amigos dos liberais, sejam eles o PC chinês ou fundos dos EUA.
🐦🔗: https://nitter.cz/MRMortagua/status/1753067353418645618#m
[2024-02-01 14:46 UTC]
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
