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So apparently the term "patch" in software development comes from punch cards.

"Small corrections to the programmed sequence could be done by patching over portions of the paper tape and re-punching the holes in that section."

chsi.harvard.edu/harvard-ibm-m

#til #computers #development #language #history

In it Idiscovered @mario_angst_sci 's organisation of a "conference satellite" in Zürich to avoid flying to Australia, a nice example of what we can do to avoid flying to distant conferences.

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The art of war:

"Pulling from cancer’s playbook, Roybal and his colleagues incorporated 71 mutations, found in cancerous T cells, into CAR T cells. When they looked at how these perturbations affected T-cell function, one mutation stood out. The CAR T cells carrying an aberrant protein dubbed CARD11–PIK3R3 infiltrated well into tumours and had long-lasting cancer-killing activity."

nature.com/articles/d41586-024

“Child deaths are rising, infant survival lags behind comparable countries, and preventable physical and mental health issues plague our youngest citizens,” said Professor Helen Minnis, co-chair of the report and an academic at Glasgow university.'

ft.com/content/ef9231b4-e997-4

Earth has more livestock than humans, wild mammals & birds combined.

Visualizing the Biomass of Life by scientific illustrator Mark Belan ⬇️ #science #art

Mimas’s surprise ocean prompts an update of the rule book for moons

The shifting orbit of one of Saturn’s moons indicates that the satellite has a subsurface ocean, contradicting theories that its interior is entirely solid.

nature.com/articles/d41586-024

Magrolimab is an anti-CD47

'Gilead Sciences, Inc. today announced it has discontinued the Phase 3 ENHANCE-3 study of magrolimab in AML and that the (FDA) placed all magrolimab studies in myelodysplastic syndromes and AML, including related expanded access programs, on full clinical hold'

gilead.com/news-and-press/comp

'Dados do Ministério da Saúde do Brasil indicam que o país registou 345.235 casos prováveis de dengue este ano, com 36 mortes e outras 234 em investigação. O número de casos triplicou entre os dias 21 e 27 de janeiro, comparando com o mesmo período do ano passado.'

expresso.pt/internacional/bras

#IDMastodon #Cardioimmunology Inflammation plays a pivotal role in the development and progression of #CVD & #viralinfections are potential triggers of inflammation. Women have a 4x higher risk of dying from #CVD if they have an infection with a high-risk strain of HPV. The evidence that viruses in general and HPV in particular increase the risk of adverse outcomes from ASCVD has become compelling enough to add to the already strong case for #vaccination against #influenza 🦠 , #SARSCoV2, & HPV

Natural History Museum of London's Wildlife Photographer of the Year award is Nima Sarikhani, for her captivating image of a polar bear sleeping on sea ice.

1 in 10 premature births in the US have been linked to pregnant women being exposed to chemicals in extremely common #plastic products, new study finds. @leotrasande:„Because they affect hormones, these chemicals can precipitate early labor & early birth".
phys.org/news/2024-02-prematur

'While the findings are striking, the observational study cannot determine whether Viagra and similar pills protect against Alzheimer’s or whether men who are already less prone to the condition are simply more likely to use the tablets.'

theguardian.com/society/2024/f

#AfricanArt #surrealism #surrealart #oilpainting or #artprint
Painting of the Day. The Happy Family XII
> > artcameroon.com/happy-family-g
@Anguwalters has created a tapestry of emotions, connecting lines and vivid colors that form a surreal family portrait.

'That probably nonexistent something is Yamagata, a lineage of influenza B viruses that hasn’t been spotted by global surveyors since March of 2020, shortly after COVID mitigations plummeted flu transmission to record lows.'

theatlantic.com/health/archive

"The United States government has placed detained immigrants in solitary confinement more than 14,000 times in the last five years, and the average duration is almost twice the 15-day threshold that the United Nations has said may constitute torture"

nytimes.com/2024/02/06/health/

"If you’ve presented the same arm for every dose of a particular vaccine, you may want to reconsider. Alternating arms may produce a more powerful immune response, a new study suggests."

nytimes.com/2024/02/06/health/

'Here, we present T-FINDER [T cell Functional Identification and (Neo)-antigen Discovery of Epitopes and Receptors], a system to rapidly deconvolute CD4 and CD8 TCRs and targets physiologically processed and presented by an individual’s unmanipulated, complete human leukocyte antigen (HLA) haplotype'

science.org/doi/10.1126/sciadv

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