Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
How the RNA vaccines activate the innate immune response & prime the adaptive response was one of the most frequent questions I got in 2020/2021.
"We discuss innate immune sensing of mRNA vaccines at the cellular and intracellular levels and consider the contribution of both the mRNA and the LNP components to their immunogenicity. A key message that is emerging from recent observations is that the LNP carrier acts as a powerful adjuvant for this novel vaccine platform"
#RNA #rnavaccines #Immunology #InnateImmunity
https://www.cell.com/immunity/fulltext/S1074-7613(22)00555-6
How the RNA vaccines activate the innate immune response & prime the adaptive response was one of the most frequent questions I got in 2020/2021.
"We discuss innate immune sensing of mRNA vaccines at the cellular and intracellular levels and consider the contribution of both the mRNA and the LNP components to their immunogenicity. A key message that is emerging from recent observations is that the LNP carrier acts as a powerful adjuvant for this novel vaccine platform"
#RNA #rnavaccines #Immunology #InnateImmunity
https://www.cell.com/immunity/fulltext/S1074-7613(22)00555-6
That's quite an opening:
"Defective host defenses later in life are associated with changes in immune system activity. The means to correct immune defects to ensure immunity in the elderly are undefined. In this study, we found that CD8+ T cells, which are necessary for anti-tumor immunity in young mice, are not required to eradicate the same cancers later in life."
(from the Kagan lab)
Thiago Carvalho
boosted
RT @lysergicdesigns@twitter.com
Our article reporting hyperfolder YFP (#hfYFP) and other fixative-resistant fluorescent proteins based on #mGreenLantern is now available at @naturemethods@twitter.com. hfYFP enhances electron- and expansion-microscopies, protein purification, and so much more! 🧵https://www.nature.com/articles/s41592-022-01660-7
🐦🔗: https://twitter.com/lysergicdesigns/status/1589734660531449856
Thiago Carvalho
boosted
RT @SandraM_Duran@twitter.com
Fully funded PhD position @ the new Traits & Ecosystems Lab @FRStewardship@twitter.com working with me on linking biodiversity observations to remote sensing to predict ecosystem function. Full ad on the link below @ESA_org@twitter.com @theATBC@twitter.com @NEON_sci@twitter.com https://traitsandecosystems.com/
🐦🔗: https://twitter.com/SandraM_Duran/status/1590525064474112000
Thiago Carvalho
boosted
Early on in the #monkeypox outbreak, there were so few deaths it seemed hard to square with the death rates from historically endemic countries. It is still true deaths have been lower in countries with access to MPX drugs & vaccines. But they had inched up. The 110 countries that have had reported nearly 80,000 cases this year have logged 44 deaths.
"Using an RNA FISH-Flow HIV-1 reactivation assay, we demonstrate that SLFN12 expression is enriched in infected cells positive for HIV-1 transcripts but negative for HIV-1 proteins. Thus, codon-usage dependent translation inhibition of HIV-1 proteins participates in HIV-1 latency and can restrict the amount of virus release after latency reversal."
#HIV #Latency #Preprint
Thiago Carvalho
boosted
Just a reminder about Mastodon.
Try not to directly upload videos here.
You have to remember that these videos have to be stored on the server that you're hosted on.
This would also eat up on available bandwidth, storage and memory resources of said servers and slow them down. Which would force server hosts to upgrade at a substantial cost.
Suggested idea...
Upload to YouTube, Vimeo or other video streaming services and share the link to the video here instead.
Thiago Carvalho
boosted
Great back-to-back read in @ScienceAdvances@twitter.com on how dynein-driven bulk microtubule retrograde flow in immature neurites drives specification of the axon: from Mithila Burute @KapiteinLukas@twitter.com et al: https://www.science.org/doi/10.1126/sciadv.abo2343 and from @MaxSchelski@twitter.com & Frank Bradke: https://www.science.org/doi/10.1126/sciadv.abo2336
You bet
"It’s now been 16 years since the publication of The Road, which makes the arrival of not one but two new McCarthy novels — rumours of which have abounded at least since he sold his archive to the Texas State University-San Marcos in 2009 — a major literary event."
https://www.ft.com/content/f3edb5d8-968e-4d0d-8bcf-ca920e1ea5df
Modeling study using #Covid19 pandemic data from 152 countries
"Although the focus of this work is retrospective, considering the merits and consequences of a more equitable sharing of vaccine between nations, conclusions can be drawn about national and international policies going forward. The message for any emerging outbreak is clear: distributing vaccines across the globe proportional to need, rather than to wealth, will have beneficial effects for all."
"Won et al. demonstrate that PD1
inhibitor treatment alone induces
myocarditis in A/J mice, creating a mouse model for immune-checkpoint-inhibitor-associated myocarditis."
Thiago Carvalho
boosted
RT @ilonaconcha@twitter.com
Do not miss this great EMBO-IUBMB workshop
@iubmb@twitter.com @EMBO@twitter.com @stephgupton1@twitter.com @GlezBillault1@twitter.com
https://neurocytoskeleton.com/2023/
🐦🔗: https://twitter.com/ilonaconcha/status/1590349099018366976
Thiago Carvalho
boosted
We're hiring a project manager with comp neuro/ #neuroscience / data or computer science background, and #scicomm skills! Apply latest Nov 30: https://ki.varbi.com/en/what:job/jobID:559908/ #openscience #datasharing
Thiago Carvalho
boosted
I'm teaching a short course on evolutionary game theory this month. Here's a 15 second derivation of the Price equation and Hamilton's rule. Two hour version and course notes found on the course repository: https://github.com/rmcelreath/VLEGT
Thiago Carvalho
boosted
With three simple steps and in just 48 hr, EZ Clear effectively renders adult mouse organs optically transparent while preserving signals from fluorescent reporters. https://elifesciences.org/articles/77419
MRC/BBRSC grant call for "vaccinology" includes both fundamental #virology and #immunology as topics.
Up to £8 million.
Deadline November 14th
SciAm interview with environmental law professor Paulo de Bessa Antunes.
"In the conversation, Bessa Antunes decried the lawlessness of the Bolsonaro years but said that Brazil has excellent environmental regulations and plenty of highly motivated people in its agencies who are ready to help Lula achieve his goals."
"While humans have been infected by birds, they are usually workers on poultry farms and those in close contact with infected birds, and even these instances have been rare. For example, on 3 November, two farm workers in Spain tested positive; it was the second known infection of humans in Europe since 2003."
The European Commission endorses #dora
"Together with the Agreement’s signature, today also marked the Commission’s endorsement of the San Francisco Declaration on Research Assessment(DORA), which sets recommendations to improve the evaluation of researchers & the outputs of scholarly research"
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
