#introduction toot!! I am a neuroscientist at Instituto Cajal in Madrid, Spain. My lab studies how the 🧠hippocampus generates activity patterns (theta, gamma and ripple oscillations) in service for memory function. We target cell-type specific microcircuits and basic neurophysiological mechs in health & disease (e.g., epilepsy). We use #ephys #neuropixels #miniscopes #uLEDs #optogenetics #computationalneuroscience #machinelearning and love developing new #openscience tools & #neurotechnologies
Uganda & @WHO will trial 3 experimental #Ebola Sudan vaccines in Uganda, the agency announced today. Interestingly, critical Phase 1 safety data will be generated in Uganda for one of the vaccines. https://www.statnews.com/2022/11/16/who-uganda-plan-to-test-three-candidate-ebola-vaccines-in-outbreak/
Job alert! Sustainability Conferencing and Communications Officer
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Care about protecting our planet?
Want to make a difference by promoting sustainability in science?
Interested in improving the sustainability of scientific meetings?
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#introduction. Group leader at IRCM. Developmental biologist by training with long standing interest in epithelial polarity and junctions.
In the lab, we study intercellular #signaling in #development and #cancer using primarily #drosophila (a bit of mice and human cancer cell lines).
Main interests:
#devbio #devbiol #DevelopmentalBiology
#physiology #cellbiology #cellbio #mechanobiology
#microscopy #imaging
Other scientific interests
#insects #evolution
#fossil #paleontology #fossilfriday
@cyrilpedia @matthewcobb Powerful words by @deborahblum, echoing strong insight from @matthewcobb:
"The rush to gene-editing brings Cobb to a kind of crisis of conscience. He is a scientist with deep respect for the profession; he’s worked with genetically modified organisms and knows they can be used for good. And yet, he cannot take that last step across the threshold of complete trust in a profession that he believes, especially recently, has failed “to speak clearly or act decisively” about its dangers. He dreams of a societal response — a world in which the public is better educated on the issues, in which scientists engage with the larger community, and informed regulation is possible. But in the interests of reality, he concedes something that, in fact, many of us outside the scientific community have also come to recognize: In the complicated reality that technology has built for us, far too often “dreams and nightmares must go hand in hand.”"
"In mice, the loss of Sharpin leads to severe dermatitis due to excessive cell death in keratinocytes. Here we report the first patient with SHARPIN deficiency, manifesting fever, arthritis, colitis, chronic otitis media and hepatic glycogenosis but unexpectedly, not associated with dermatologic manifestations."
#Immunology #HumanGenetics #Immunedeficiency #LUBAC #Sharpin
https://www.medrxiv.org/content/10.1101/2022.11.09.22281431v1
RT @zhang_chuchu
We are paying $3400 for infant daycare at Harvard. In 2017 as a first year postdoc, this is higher than my post tax salary. It does not make sense financially to work as a postdoc and to raise a kid. You wonder why some women quit science at this point?? https://twitter.com/sa_redmond/status/1592253642655993856
"The need remains for the funding and development of predesigned, adaptive trial protocols for diseases with epidemic or pandemic potential that can be timely pulled off the shelf and launched early in an outbreak, leveraging ready clinical trial networks and infrastructure for rapid discovery and implementation of new treatments."
RT @NicolaKelly@twitter.com
As part of an investigation into the drownings of 32 people in the Channel last year, the French authorities have disclosed their call log, which shows more than 20 distress calls were made to British and French coastguards. It took 9 hours for anyone to respond.
The transcripts:
🐦🔗: https://twitter.com/NicolaKelly/status/1592189573094060034
OK so hi I’m an astrophysicist and a sometimes science writer who spends way too much time on the ~~~other site~~~ so is checking this one out. I enjoy clever word things and science and dogs. #introduction
📢 Please RT
Join our #fly neuroscience lab.
4 year fully funded #phD fellowship to study how animals make decisions during conflicting situations. #neuroscience #drosophila
Deadline 20th Jan
Get in touch with questions.
Nanoscale resolution with Iterative U-Expansion microscopy (iU-ExM). Check out @louvel_vincent 's paper. Yes it is an image of a centriole with a simple confocal 😱😱https://www.biorxiv.org/content/10.1101/2022.11.14.516383v1.full.pdf
Improved discovery of RNA-binding protein binding sites in eCLIP data using DEWSeq
from Hentze lab
@brian_gettler I've been saying for many years that for STEM students, courses in philosophy are indispensable both for detecting and refuting bad arguments, as well as for thinking well more generally. My view is that philosophy, literature, and history should be elevated at the expense of all the science requirements we impose.
That said, for Scientific American I was asked to write about what needs to be different *in the science classroom*.
Perhaps that is the source of confusion.
O Nº1 da Almanaque está online em
https://almanaquemag.com/
_
Ilustração de Lia Ferreira (@liaferreira),
layout de João Lagido.
Que palavra ou discurso poderia
Dizer amar na língua da semente?
100 anos de #Saramago.
📷 João Francisco Vilhena
"Early on Tuesday, Mr. Musk’s team ordered nearly two dozen Twitter employees who had pushed back publicly and privately against him to be fired, three people with knowledge of the matter said. The billionaire, who completed a $44 billion acquisition of Twitter last month, later confirmed the exits on the platform and mocked the former employees."
https://www.nytimes.com/2022/11/15/technology/elon-musk-twitter-fired-criticism.html
"Despite revolutions, sieges, World War I shelling, and World War II bombings, Paris still possesses a remarkable architectural unity. The city’s center looks much as it did in the late 19th century. But while the scars are not immediately visible, they are there, and the worst of them are self-inflicted: the product of a single hideous week in May 1871. This was the week that the Paris Commune died."
#InnateImmunity #MucosalImmunology #Covid19 #SarsCoV2 #Preprint #Immunology
"We designed a study to characterize the expression of interferon alpha-2 (IFNA2) and interferon beta-1 (IFNB1), both type-1 interferons (IFN-1), interferongamma (IFNG), a type-2 interferon (IFN-2), ISGs, and NF-κB response genes in the upper respiratory tract (URT) of patients with mild (outpatient) versus severe (hospitalized) COVID-19. Further, we characterized the weekly dynamics of these responses in the upper and lower respiratory tracts (LRTs) and blood of severe patients to evaluate for compartmental differences."
https://www.medrxiv.org/content/10.1101/2022.11.08.22281846v1
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com