A belated introductory toot. I'm a journalist at the Financial Times, and currently work at Alphaville, our finance blog.
I live in Oslo, and I'm Norwegian despite the weird last name. (That means I am required to care more about the Eurovision Song Contest than any sane person should.) I also wrote a book, Trillions, which you should buy.
Btw, FTAV has our own server now, alphaville.club, which we might - time permitting - try to turn into a little community for finance geeks like us.
Modeling mammalian spermatogonial differentiation and meiotic initiation in vitro
An #OpenAccess T&R article from Oleksandr Kirsanov, Christopher Geyer and colleagues
This article is available under our Read & Publish Open Access initiative.
Researchers can find out about the benefits, read what researchers are saying and view a list of participating institutions at https://www.biologists.com/library-hub/read-publish/researchers/
"Here, we have identified the mTOR pathway as a major determinant of chemosensitivity through a genome-wide CRISPR knockout screen. We show that mTOR inhibition causally leads to the emergence of a reversible drug-tolerant persister population with a senescence phenotype, which is dependent on autophagy and G2/M cell cycle arrest for survival."
'Seen in this light, the defensive survival circuits of humans and other mammals can be conceptualized as manifestations of an ancient survival function—the ability to detect danger and respond to it—that may in fact predate animals and their nervous systems, and perhaps may go back to the beginning of life. Fear, on the other hand, from my perspective, is a product of cortical cognitive circuits.'
- J. LeDoux
https://royalsocietypublishing.org/doi/full/10.1098/rstb.2021.0292
Did you ever wonder about the differences between engineered T cell receptors (TCRs) and chimeric antigen receptors (CARs) in current T-cell therapy approaches for the treatment of #cancer?
Here is a comprehensive #openaccess review article by researchers at Miltenyi Biotec and the German Cancer Research Center (DKFZ) summarizing similarities and differences by directly comparing the architecture, synapse formation, and signaling of TCRs and CARs: https://www.mdpi.com/1422-0067/23/23/14563
Human immunology from the Eisenbarth lab
"The aim of our study was to characterize infant gut food-specific IgA responses and determine whether gut and plasma food-specific IgA are related to tolerance to food allergens. We found that non–food-allergic infants make gut peanut-specific IgA. We next demonstrated that gut peanut-specific IgA did not correlate with measures of future peanut allergy outcome nor did it correlate with peanut tolerance. We also observed that gut egg white-specific IgA was higher in egg-allergic children and did not predict outgrowth of egg allergy. Our data also revealed that there are no differences in the epitopes targeted by gut peanut-specific IgA between peanut-allergic and nonallergic children but that epitope specificity is different between gut peanut-specific IgA and plasma peanut IgE. Overall, these findings challenge the commonly presumed protective role of food-specific IgA."
Doing an interview with the BBC to promote my upcoming musical “Allegiance” in London.
This is my legacy project, the work I am most proud of and am most eager to share with UK audiences. It tells the story of our community, when 120,000 Japanese Americans were put into barbed wire prison camps during WWII because we resembled the people who bombed Pearl Harbor.
Allegiance is a celebration of the human spirit over adversity. #NeverForget
For tickets visit: https://allegiancemusical.com
RT @uni_tue_exstra@twitter.com
Apply now! Join the Teach@Tübingen Postdoc Fellowship Program and stay fully funded for 1-2 semesters at a German top university with an excellent research environment: https://uni-tuebingen.de/en/141598 #Postdocs #ExcellenceStrategy #Civis_eu
🐦🔗: https://twitter.com/uni_tue_exstra/status/1595357834937507847
"But some tragedies really are catastrophically destructive. The fire at the National Museum of Brazil in 2018 destroyed mountains of unique recordings of indigenous languages, irreplaceable archives of extinct languages, and physical artefacts. When a copy of a book gets burned, it can always be replaced if people care. But much of what was lost that day was lost for good. The fire of Rio de Janeiro was far more destructive than the incidents at Baghdad or Alexandria."
http://kiwihellenist.blogspot.com/2022/11/alexandria.html?ref=the-browser
A VICTORIAN MERMAN.
Objects like this were sometimes made from the torsos of monkeys and the tails of fish. They were displayed by showmen like P. T Barnum to audiences who believed they were real. This particular one is on display at the Horniman Museum. It was recently x-rayed and curators discovered it had a wooden and wire frame inside with fish skin stretched over its tail. It has rows of teeth that were carved from bone and the hair is human.
Follow me for more #WeirdHistory! #histodon
Why shouldn’t you just delete your #twitter ? Abandoned social media accounts represent the same risk as abandoned domain names. Name #squatting works because reputation and influence gets attached over an account’s life -Those followers you spent time building up don’t just dissipate when you go. For a threat actor this is a huge opportunity. Some accounts carry more #influence than presidents. So if you stop using an account purge it, leave a last message, then securely lock it. (Please share)
RT @matthewcobb@twitter.com
@ewanbirney@twitter.com And for the bicentenary there is a terrific new biography out by Michel Morange! https://www.fnac.com/SearchResult/ResultList.aspx?Search=pasteur+michel+morange&SCat=0%211&sft=1&sa=1
🐦🔗: https://twitter.com/matthewcobb/status/1595351701921439745
RT @yoavrec
🔥 My PhD work is finally published! @CellReports
We showed how running improves neuronal code quality and affects its stability in mice. Here’s a short thread on what we found (and how we studied it) >>
https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01569-8
RT @emollick@twitter.com
Humans are pattern-finding machines & some patterns call to us more.
This neat paper finds that, across 27 cultures, we tend to name the same patterns of stars, mostly because the perceptual systems of humans are all drawn to the same types of patterns. http://www.charleskemp.com/papers/kemphlc_perceptualgroupingexplainssimilaritiesinconstellationsacrosscultures.pdf
RT @BIRDlab_ENS@twitter.com
Louis Pasteur fête ses 200 ans!
Regard, dans @lemonde_science@twitter.com, sur ce personnage scientifique dont les idées en germes ont ensemencé bien des recherches ultérieures et des changements dans la société.
🐦🔗: https://twitter.com/BIRDlab_ENS/status/1595336919503802370
'The discussion swirling around immunity debt shows how easy it is for a plausible-sounding theory to circulate as misinformation. In this case, misinformation risks promoting the unfounded assertion that infections are clinically beneficial to children, as well as feeding the revisionist narrative that Covid measures did more harm than good.'
cc @BLMG
#Immunology #Virology #COVID19
https://www.ft.com/content/0640004d-cc15-481e-90ce-572328305798
Five white egrets. 1927.
By Ohara Koson, Tokyo.
From Te Papa, Wellington https://collections.tepapa.govt.nz/object/1529420
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com