Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
"People survive by passing information between themselves...We’re putting that fundamental quality through a process with an inherent incentive for corruption and degradation" https://www.theguardian.com/technology/2022/nov/27/jaron-lanier-tech-threat-humanity-twitter-social-media
Thiago Carvalho
boosted
We're hiring a senior editor at Scientific American to help run our opinion, commentary & analysis coverage. Thanks for applying or recommending the job to people you think would be good candidates. https://careers.springernature.com/job/New-York-Senior-Opinion-Editor%2C-Scientific-American/866115301/
Thiago Carvalho
boosted
RT @LabListon@twitter.com
For anyone doing #flowcytometry, would you like to have a new protocol that reduces your #antibody costs by ~10-fold and also gives you higher quality data, with better signal-to-noise ratio?
Yes? Then read work by @olivertburton@twitter.com and @CarlyEWhyte@twitter.com. 1/6
https://currentprotocols.onlinelibrary.wiley.com/doi/epdf/10.1002/cpz1.589
🐦🔗: https://twitter.com/LabListon/status/1592270393578065921
Thiago Carvalho
boosted
Nothing in biology makes sense except in the light of RNA sequencing, but what if you can't analyze the data? We (mostly Guy) created a software to make your life easy! Read our NEW preprint & REBLOG. Please try it (follow the detailed tutorial) and give us feedback! 🤟🙏
"RNAlysis: analyze your RNA sequencing data without writing a single line of code"
https://www.biorxiv.org/content/10.1101/2022.11.25.517851v1
Here's Guy's thread with all the details:
https://twitter.com/GuyTeichman/status/1596193414885810180?s=20&t=25MH4VPG-6PcqObk04bjVA
Thiago Carvalho
boosted
So I hope the study is interesting and useful! In some ways, it is a negative results paper. But we believe it contributes an important set of observations for the field. We find AMPs do not intrinsically affect lifespan in flies.
We also show how a cryptic viral infection can greatly impact how we might have interpreted our results (fig incl), and reflect on the many challenges we were conscious of as we prepared our final manuscript.
Thiago Carvalho
boosted
https://www.biorxiv.org/content/10.1101/2022.08.24.504952v2
Our study on intrinsic effects of AMPs to healthy aging has now been reviewed by Review Commons! You can find the reviews via TRiP and our response letter (✅ in tabs on bioRxiv). Reviewers commented on a lack of sex-specific effect discussion, which I think makes for a great thread topic 🧵:
“Your scientists were so preoccupied with whether or not they could, they didn't stop to think if they should.”
Clive Barker entomology
(Lisbon Natural History Museum)
'My argument was that it’s a really bad scientific strategy to just invent some mathematics, then proclaim we have to go and test it when there’s no reason it should work. There are infinitely many of those particles you can make up, and it’s not working. Just look at what’s come out of it in the past 40 years.'
'Here, we used genetically diverse C. elegans strains to perform dose-response analyses across 26 anthelmintic drugs that represent the three major anthelmintic drug classes (benzimidazoles, macrocyclic lactones, and nicotinic acetylcholine receptor agonists) in addition to seven other anthelmintic classes.'
'An abstractionist before the official advent of abstraction, Hilma af Klint was a member of an all-female group called the Five from 1896 to 1907, participating in meditation and séances to channel the messages of mystics. In the studio, she harnessed this spiritual practice into unorthodox, nonfigurative paintings.'
Thiago Carvalho
boosted
RT @angifeldmann@twitter.com
Apply now. Our lab is hiring to work on exciting projects at the interface of gene regulation, 3D genomics and carcinogenesis. https://twitter.com/michael_boutros/status/1595476612446838784
🐦🔗: https://twitter.com/angifeldmann/status/1596756908546801669
Thiago Carvalho
boosted
RT @marcsdionne@twitter.com
This is an absolute monster of a paper, borne of @Krista_L_Grimes@twitter.com and @EstebanBeckwith@twitter.com making the mistake of taking me seriously when I said we should knock down *all* the enzymes—and then, when we still weren't sure of phenotypes, making isoform-specific mutants https://twitter.com/Krista_L_Grimes/status/1596539924148551688
🐦🔗: https://twitter.com/marcsdionne/status/1596552311630962689
Thiago Carvalho
boosted
@francoisleulier Thanks François! Ob link to paper https://www.biorxiv.org/content/10.1101/2022.11.25.517956v1
'In a cleverly designed experiment, Galvez-Pol et al. used electrocardiography to record the cardiac activity of participants while they performed a simple tactile discrimination task. Without looking, the participants had to figure out whether the objects they touched had vertical or horizontal grooves. They found that touches initiated during systole were held for longer than touches initiated during diastole'
Thiago Carvalho
boosted
Let me introduce myself! My name is Ilenna Jones, I am a computational neuroscientist with keen interest on how dendrites contribute to a singular neuron's ability to compute functions and learn tasks. I build biophysical models of neurons in #pytorch and use #deeplearning principles to investigate how #neuron models can learn and compute given their biologically realistic constraints.
I'm looking for postdocs right now! Feel free to connect if you're looking for someone like me!
I'm very interested in helping other students find resources and guidance as they consider science and #neuroscience in general. Feel free to connect if you're looking for advice/perspectives!
#computationalneuroscience #theoreticalneuroscience #neuroscience #neuralcomputation #learning #modeling #BlackInNeuro #FirstGen #Questbridge
ilenna.com
'Whether these trees succeed in this slow-motion migration — and eventually grace new landscapes with their noble, carbon-sequestering, shelter-providing, wildlife-nourishing presence — will be a function of countless encounters between a mouse or a vole and an acorn.'
https://www.nytimes.com/2022/11/25/science/climate-forests-seeds-mice.html
Thiago Carvalho
boosted
Our UPenn group led by Scott Hensley just published a paper in @sciencemagazine on multivalent (universal) mRNA flu vaccine that targets all 20 clades.
Animal study produced high neutralizing antibodies vs all 20 , and protected vs severe/fatal disease.
Next steps NHP studies and phase 1 clinical trials
Since one of the main challenges with vaccinating fluid inability to target all 20 clades, this is a potential game changer
https://www.science.org/doi/10.1126/science.abm0271
Thiago Carvalho
boosted
RT @sevillegauthier@twitter.com
EXTRA EXTRA, looking for an outstanding PhD candidate to join our team @cabimer@twitter.com @FProgresoysalud@twitter.com @saludand@twitter.com in our fight against #t1d and other autoimmune diseases. Tweeter friends please retweet to spread the news 👍💪⬇️⬇️⬇️
🐦🔗: https://twitter.com/sevillegauthier/status/1596143058793689088
"In 2019, the U.S. Centers for Disease Control and Prevention estimated that 18 superbugs—both drug-resistant fungi and bacteria—cause at least 2.8 million drug-resistant infections every year in the United States, resulting in more than 35,000 deaths (2). Of the 18 microbes, three are fungi: Candida auris, according to the CDC, is an “urgent threat,” drug-resistant Candida species are “serious threats,” and azole-resistant Aspergillus fumigatus is on the “watch list.”"
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
