Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
"A higher aneuploidy score is associated with poor prognosis following immunotherapy among tumors with low TMB, but not those with high TMB."
Thiago Carvalho
boosted
An impressive visualization of the SARS-CoV-2 life cycle. https://www.youtube.com/watch?v=XlOi2hVGtg0&t=2s
'Interestingly, combined treatments including phages and a wide range of antibiotics lead to an increased bacterial killing, a phenomenon called phage-antibiotic synergy (PAS), suggesting that antibiotic-induced changes in bacterial physiology alter the dynamics of phage propagation. Using single-phage and single-cell techniques, each step of the lytic cycle of phage HK620 was studied in E. coli cultures treated with either ciprofloxacin or cephalexin, two filamentation-inducing antibiotics.'
#Phage #Antiobiotics #preprint
https://www.biorxiv.org/content/10.1101/2022.11.28.518157v1?med=mas
Thiago Carvalho
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3,013 neurons, half a million synapses: the complete #connectome of the whole #Drosophila larval brain!
Winding, Pedigo et al. 2022. "The connectome of an insect brain" https://www.biorxiv.org/content/10.1101/2022.11.28.516756v1
We’ve mapped and analysed its circuit architecture, from sensory neurons to brain output neurons, as reconstructed from volume electron microscopy, and here is what we found. 1/
Thiago Carvalho
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Hospital wastewater shouldn't be a reservoir for *any* antimicrobial resistance really...😓 
#AMR #IDMastodon #microbiology https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(22)00326-3/fulltext?dgcid=raven_jbs_aip_email
Thiago Carvalho
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Preparations are well underway for #DevMeeting23 on ‘Unconventional and Emerging Experimental Organisms in Cell and Developmental Biology’, organised by @sarur @jamesbriscoe Gautam Dey and Cassandra Extavour.
Our meeting page is live and you can check out the list of confirmed speakers and register for updates on the programme and key dates.
https://www.biologists.com/meetings/unconventional-organisms-23/
Thiago Carvalho
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We moved to science mastodon.
@ASCBiology@sciencemastodon.com
Thiago Carvalho
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I always wondered how Bell Labs, a private lab, could be so successful and win 9 (!) Nobel Prizes. The answer seems to be a continuous stream of funding and an environment that valued longterm research goals and scientific discovery over progress reports.
Thiago Carvalho
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I am a second-year PhD student at Cambridge Uni in mathematical #epidemiology. In particular, I am interested in #virus #evolution during #epidemics
I also did my undergrad and my master's in applied #maths and theoretical physics at Cambridge, but I'm from Madrid.
Thiago Carvalho
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Do you use a lot of #genomic data in your research or are you considering getting a direct-to-consumer #WholeGenomeSequencing kit for the holidays? Here's a really great review from #NatureReviewsGenetics that covers the technological and legal protections for genomic data: https://www.nature.com/articles/s41576-022-00455-y #science #medicine #genetics #privacy #genome #WGS
Thiago Carvalho
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In 1952 Rosalind Franklin & Raymond Gosling collected their famous diffraction pattern of #DNA, photo 51.
But did you know that Elwyn Beighton, in #Leeds produced a strikingly similar image the year before? For some reason his boss, Bill Astbury wasn't interested & so they never published the work.
#HistSci #Chemistry #Chemiverse #science
https://www.sciencedirect.com/science/article/abs/pii/S1369848610001111?via%3Dihub
The Moore's Law scrolls:
'In 2005, realizing they lacked an original copy of “Cramming,” Intel executives offered $10,000 on eBay for a mint copy of the relevant issue of Electronics. At last, an engineer in Surrey, UK, found one under his floorboards. The enchanted pages now sit in climate-controlled splendor in Intel’s museum—the tech world’s Book of Kells.'
'For Volker Höffer, who directs the Stasi archive in Rostock, those who consulted their files almost always found it a liberating experience – especially if they had been persecuted as a result of Stasi spying. “In numerous conversations, those affected told me that they could now dissolve dark holes within themselves,” he says. But he also saw it as a necessary step for Germany as a whole, an attempt to “extract the eternal essence of dictatorships and to develop from it a serum against future ones”.
'However, the study of conserved regions excludes functional elements that descended from previously neutral regions. Here, we demonstrate that the fastest-evolved regions of the human genome, which we term “human ancestor quickly evolved regions” (HAQERs), rapidly diverged in an episodic burst of directional positive selection prior to the human-Neanderthal split, before transitioning to constraint within hominins.'
Thiago Carvalho
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Job: Technical & Executive Assistant to the World Conservation Monitoring Centre CEO - Cambridge, UK
#Job #NGO #Conservation #biodiversity #Cambridge #UK
Technical and Executive Assistant to the World Conservation Monitoring Centre (#WCMC) CEO
https://www.unep-wcmc.org/en/careers/technical-and-executive-assistant-ad1296b
Thiago Carvalho
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Great article on #COVID rapid antigen #testing and #hospitalization and community #transmission in the #BMJ. Bottom line: Large scale asymptomatic rapid testing for SARS-CoV-2 could help reduce transmission and prevent hospital admissions. #publichealth #causalinference #epidemiology
Thiago Carvalho
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🔖 Statistical code in a high-impact medical journal
A journal started asking authors to submit code with their manuscripts. They then analysed the next 314 papers accepted
87% denied using code, even when publishing substantial statistical analysis
10% used code but refused to share it with the journal
For the few that provided code, none scored even moderately on basic quality criteria
Assel & Vickers
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705117/
#MedMastodon
#OpenScience
#ResearchWaste
#doi:10.7326/M17-2863
Thiago Carvalho
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Wow! Structure of the divisome core complex by Löwe lab. Essential reading for bacterial cell biologists https://www.biorxiv.org/content/10.1101/2022.11.21.517367v1
Thiago Carvalho
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I have a new vacancy in my team for cryoEM scientist interested in developing cryoFIB milling approaches and cellular cryoET. As always, we will be pushing the boundaries with cryoET #teamtomo. Position is based at Oxford, UK. Please help spread the word. https://jobs.thermofisher.com/i/global/en/job/222364BR/Applications-Scientist-Cryo-Tomography
Thiago Carvalho
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I'm still finding my feet here, so it feels right to share with you the first #JournalCover I ever got with my #sciart
I was a #postdoc at the time and I had 1 evening to produce something around the idea that virulence in #bacteria is often 'all about the #phage ... '
A lucky break for me!
#MastoArt #Introduction
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
