Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
'What types of responses can occur transgenerationally? Can the brain coordinate these responses?'
Throwback to the Fall of 2021, the second #EMBOPodcast with @Odedrechavi "Physiologically Irreverent"
'Using genetic knockouts and specific inhibitors, we demonstrate that glycosaminoglycans, integrins, and the TGF-β signaling axis are required for S-mediated barrier dysfunction. Notably, we show that SARS-CoV-2 infection caused leak in vivo, which was reduced by inhibiting integrins. Our findings offer mechanistic insight into SARS-CoV-2-triggered vascular leak, providing a starting point for development of therapies targeting COVID-19.'
#SarsCoV2 #Covid19 #TGFbeta
https://www.nature.com/articles/s41467-022-34910-5
"The concept that scientific articles can be bought and sold (8–12) contradicts everything that most researchers wish to believe about scientific publishing, and some readers may doubt that paper mills exist. We will therefore summarise what is known or predicted of paper mill operations and their likely drivers and enablers. We will summarise the evidence that paper mills have contributed to the human gene research literature at scale and describe why human gene research may be particularly vulnerable to industrial-scale research fraud."
Thiago Carvalho
boosted
@explainpaper inspired by @halama_immuno
Targeting Tumor-Promoting Microenvironment Through CCR5 Blockade in @colorectal @cancer @liver Metastases
#Cancer progression is a process in which cancer cells and #immune cells interact with each other in a way that can lead to the growth and spread of cancer. In #colorectal cancer, when the cancer has spread to other parts of the body, it is called @metastasis and it is very difficult to treat.
Thiago Carvalho
boosted
RT @RareGenomicsRSA
@danrdanny @shahida_moosa We're not a consortium (yet), but our rapidly expanding Undiagnosed Disease Programme is a first for sub-Saharan Africa.
#Genomics for #RareDiseases in #Africa
https://onlinelibrary.wiley.com/doi/10.1002/ajmg.a.62847
- for initial results. Since then, more than double the number of families have been tested!
Thiago Carvalho
boosted
Anne Collier era uma das pessoas responsáveis pela segurança e moderação no Twitter. Ela e dois colegas demitiram-se hoje, em colisão com Musk.
Mike Cernovich é um neo-fascista responsável por uma máquina de fake news e promotor de teorias do QAnon.
Instrumentalizando o tema da pedofilia (técnica habitual do QAnon), Cernovich ataca Collier.
Musk sai em defesa do neo-fascista, atacando a perita em segurança e moderação digital.
A mini-novela termina com o ex-dono do Twitter a desmentir Musk.
'In #malaria parasites, sexual reproduction coincides with transmission to the vector host. Sex determination is non-genetic, with each haploid parasite capable of producing either a male or a female gametocyte in the human host. The hierarchy of events and molecular mechanisms that trigger sex determination and maintenance of sexual identity are yet to be elucidated.'
#Plasmodium
'It is remarkable, for example, that much of the funding for challenging current practice in evolutionary biology comes from The John Templeton Foundation (Pennisi 2016), which is committed to using science to reveal underlying purpose, and rejecting what Nagel (2012) calls “the Materialist Neo-Darwinian Conception of Nature”. But perhaps this is just history repeating itself as farce: if poetry couldn’t save us, nothing on the laundry lists will either.'
(fm 2017)
Thiago Carvalho
boosted
From superman squirrels to turtle bridges - the winners of the 2022 Comedy Wildlife Photography Awards:
https://www.comedywildlifephoto.com/competition/competition-2022-winners.php
Thiago Carvalho
boosted
Did you know that for centuries, a “gossip” was a woman who attended her pregnant daughter’s, sister’s, or friend’s delivery? The word was a corruption of “god-sib” or “god-sibling,” meaning “sister in the Lord.” The gossips offered emotional and physical support to mother and midwife. It was only later that the term took on a derogatory meaning.
This remarkably detailed wax anatomical model (c.1787) is now housed at the Javier Puerta Museum.
Thiago Carvalho
boosted
RT @PSarkies@twitter.com
I have a postdoctoral position available for a computational project in my lab.
Advert is here:
https://my.corehr.com/pls/uoxrecruit/erq_jobspec_version_4.display_form
Although currently short-term there may be opportunities to extend, and also to use the position to apply for fellowships.
Please retweet!
Thiago Carvalho
boosted
"The pandemic has been a very challenging time for preprints in the Health Sciences. There was a lot of media reporting on preprints in the early days of the pandemic. Many of these didn't get to be published and had serious flaws"
< I was interviewed on my #OpenResearch practices
Thiago Carvalho
boosted
Delighted to share that my first ever first-author paper is now out from Cell Reports! We started out with a gene, a behavioral phenotype, and no idea what was going on at the circuit level to link those things. Classic genetic methods (temporal-specific and cell-type-specific rescue) told us the gene acts acutely in neurons-- but which ones? We developed a computational method that ended up IDing a new projection to the decision-making circuit! https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01678-3
'In an equivocal recommendation letter to the dons at Oxford, R.S. Thompson, a housemaster at Sherborne School, Dorset, wrote that his former pupil David Cornwell “strikes me as the sort who might become either Archbishop of Canterbury or a first-rate criminal!”
https://thebaffler.com/salvos/the-father-of-all-secrets-adler-bell
Thiago Carvalho
boosted
I'd better do another #introduction now I've moved my #fediverse home.
Hi, I'm Dave. I'm a Principal Laboratory #Research #Scientist (aka. Scientific officer) at the Francis Crick Insititute in #London.
I'm a #StructuralBiologist by training. I help run a group that studies #Kinase #signaling in human #health and #disease.
I do #Crystallography #CryoEM #Biophysics #DrugDesign and #Glycobiology. #Science
Thiago Carvalho
boosted
Very cool Preprint another the antibacterial arms race:
Structural basis for translation inhibition 1 by the glycosylated antimicrobial peptide Drosocin from Drosophila melanogaster
@strucbio #CryoEM #Science
http://biorxiv.org/cgi/content/short/2022.12.08.519698v1?rss=1
'Tutankhamun himself was beset with poor health. CT scans and DNA analysis of his mummified body have revealed that he suffered from a cleft palate, withered leg (he walked with the aid of a stick, several examples of which were buried with him), and multiple bouts of malaria. His death, before he reached his 20s, was not unusual for the time.'
https://aeon.co/essays/what-king-tuts-treasures-reveal-about-daily-life-in-ancient-egypt
Thiago Carvalho
boosted
During winter in lockdown, myself and a few friends had a #photography project which was basically walking around the streets at night, taking photos of #Bristol and the 'nightlife' that remained when we were without our usual social venues. It was actually really good for our collective mental health to have something to focus on, and important to document a time in our lives that was just really weird.
Thiago Carvalho
boosted
Big effort @BRxAD & co looking at impact of #COVID19 on #AMR.
Heterogeneity in many factors but possibly some increase in Gram negative resistance seen overall.
#MedMastodon #IDMastodon
Thiago Carvalho
boosted
It's that time of the year where I teach our 1st year #DataScience students about data *in the wild*
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
