Thiago Carvalho @cyrilpedia@social.cleverlibre.org

@PessoaBrain @hsalis @jason_ritt @neuralreckoning @WorldImagining @NicoleCRust @matthewcobb @WiringtheBrain

Classical cytoarchitectonic work of reptile cerebral cortex is wrong. Tosches and Laurent (2018) https://www.science.org/doi/full/10.1126/science.aar4237 demonstrated that not only all inhibitory neuron types are there except for Chandelier cells, but also the layering is far more elaborate and much closer to mammals than ever known before.

I'm asking a ton of questions this week...

How do you #license your #bioinformatics code? What about tools? Software packages? New analysis methods? Code you wrote specifically for one project?

Do you keep your repositories private or public before #publication?

Can we discuss #intellectualproperty of #code during and after the publication process? Do you fear someone might "steal" your idea if you work for a long time in public repos before publication?

Development of an antibody fused with an antimicrobial peptide targeting Pseudomonas aeruginosa: a new approach to prevent and treat bacterial infections http://biorxiv.org/cgi/content/short/2022.12.28.522163v1?rss=1

#IDMastodon #Immunology @cellpress Understanding the mechanisms of viral clearance & immunopathology that accompanies #COVID19 & role Plasmacytoid dendritic cell during #SarsCoV2 infection .
📌https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00957-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124722009573%3Fshowall%3Dtrue
📌https://europepmc.org/article/med/35996885
📌 https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9538918&blobtype=pdf

An #assembloid -like model system was used in a cohort of #breastcancer patients to test the utility in #treatments selection...with interesting results, putting approaches with #organoids and #explantmodels in #Oncology to the test for #stratification and #PersonalizedMedicine
@gpollara @cyrilpedia
https://www.pnas.org/doi/10.1073/pnas.2209856120

A reminder for biologists about this great resource by Robert I. Colautti. Free pdf here: https://github.com/ColauttiLab/RCrashCourse_Book #RStats

Check out this amazing lineup of workshops at Janelia!
https://www.janelia.org/you-janelia/our-research/conferences-and-workshops

It’s not always easy to identify a #COVID19 death. New research shows such inaccuracies also are more likely for Americans who are #Black, Hispanic, Asian, or Native. https://www.texasobserver.org/the-uncounted-people-of-color-are-dying-at-much-higher-rates-than-covid-data-suggest/

With the Documenting COVID-19 Project at Columbia University’s Brown Institute for Media Innovation, MuckRock, Boston University’s School of Global Public Health the USA TODAY Network, the #Arizona Center for Investigative Reporting and Willamette Week in #Portland.

#news #health #indigenous #covid

We’ve just launched a new research program for immuncompromised individuals in the US with free home molecular testing and rapid access to medications when needed. Please help spread the word 👇
https://immunocare.scripps.edu

I did not realize murine and human LNs have these differences.

"mouse LNs have a clear paracortical sinus system; these sinuses originate from the paracortical lymphocyte-rich area of the LN parenchyma without forming physical contact with the SCS, and empty into the medullary sinus. In humans, the SCS makes prominent radial invaginations (trabecular sinuses) into the LN stroma, whereas this sinus system is not found in mice." #Immunology

https://www.cell.com/action/showPdf?pii=S1471-4906%2822%2900235-6

Rest in Power, REI
---
RT @TheKingCenter
Rest in Peace, #Pele. Thank you for all the joy you brought to the world.
https://twitter.com/TheKingCenter/status/1608558891188494336

Over many years, I have been gradually replacing all of the paragraphs in the Ship of Theseus Wikipedia article.

Our new paper on modelling the #spatiotemporal dynamics of a beneficial genetic variant is out @eLife.
Muktupavela et al: https://elifesciences.org/articles/73767
Plus a digest highlight here: https://elifesciences.org/digests/73767/evolving-through-time-and-space

We extend a #diffusion method for inferring the spread of a strongly selected allele, originally developed by Novembre et al. (https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.0030339). We now incorporate #ancientDNA and allow for #advection dynamics.

#EvolutionaryGenetics #Evolution #Genetics #EcoEvo #archaeology #HumanEvolution

The delicate balance between CD4 and CD8 T cells within solid tumors: a new aspect of the role of CD4 T cells in a glioblastoma model reveals possible synergies with a CD40 agonistic approach. #immunology #Oncology #Immunotherapy #Lymphocytes
https://jitc.bmj.com/content/10/12/e005293

I cannot keep this to myself. There is a website (radio.garden) where you can listen to radio stations all over the world for free. No log in. No email address. Nothing.

When the site loads, you are looking at the globe. Slide the little white circle over the green dots (each green dot is a radio station) until you find one you like.

I have been listening to this station in the Netherlands and it absolutely slaps. I have no idea what they're saying but the music is fantastic.

#Introduction Time! I'm a developmental neurobiologist doubling as a cell biologist & microscopist. My fantastic team and I work at St. Jude Children's Research Hospital in #Memphis.

Our lab interfaces with neural development and tech implementation to produce a quantitative and mechanistic entry point to understand cell polarization and neuronal differentiation. We work with a strong team mindset to discern the role of cell polarity health & disease.

Here's a little #sciart video: