'At the core of these attempts to stratify sensation was the implicit assertion that pain was a physical phenomenon, expressive of the relation between peripheral nerves and the brain. Through most of the 20th century, Western medical scientists laboured under the misconception that the experience of pain could be pegged to a scale of intensity.'
https://aeon.co/essays/pain-is-not-the-purview-of-medics-what-can-historians-tell-us
An RNA labelling approach for measuring the cellular response to tissue dissociation, a major confounding factor in #singlecell #transcriptomics ➡️ http://bit.ly/3VJFSC5
Junker Lab, BIMSB,
@MDC_Berlin
#SystemsBiology #Genomics #GeneExpression #SLAMseq
"Ali El Mekaniki works in an orchard overlooking the town, owned by the local Greek Orthodox monks. It once enjoyed a favourable, sheltered climate, but now the olive flowers wilt in the April heat and unpredictable blasts of cold in May hobble the fruit. In town, the herbalist, Ahmed Saleh, said the drier weather had led to dustier winds: ‘The herbs are unhappy.’"
📢SEASONAL JOBS CLOSING: @RSPB #RSPBScience is looking for ~40 seasonal #Research Assistant & Senior Research Assistants for 2023 #fieldwork!
From #Seabirds to Ring Ouzels, Turtle Doves to Hen Harriers, please check out the webpage & apply! https://bit.ly/3uW8GfO #Ornithology
In the same context of #gene regulation #epigenetics my second read of today:
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001944
I just found my read of the day:
https://www.biorxiv.org/content/10.1101/2022.12.31.521782v2
It makes so much sense to me that differentiation pathways in T cells(and biological processes i general) are much more flexible than currently depicted in literature! Why would a cell be fully stuck in one state with no way to return? HIgh time for studies like this to correct our current view on #immunology #memory #T cell #differentiation #gene regulation. So i look forward to read it!
Happy New Year 2023!
Our first issue brings:
#Calreticulin conformation changes in cold response
Mammalian #CDC14 #phosphatase controls #stemness exit in #pluripotent cells
#Exosomal #interleukin release via #IQGAP1-mediated #gasdermin-#ESCRT bridging
#Microglial TNFα and cortical protein #phosphorylation during #sleep
...and more:
https://www.embopress.org/toc/14602075/2023/42/1
Flore Castellan & Naoki Irie set up a transgenic mouse model to specifically deplete maternal cells in neonates. Subsequent immunophenotyping reveals that this depletion leads to early activation of splenic T and natural killer cells:
#Immunity #ImmuneSystem #AcademicMastodon #BiologyOpen #Biology #Science #MaternalCells
We found novel #papillomaviruses, that are prevalent, diverse, and with complete genomes, in the critically endangered Malayan and Chinese pangolins #paleovirology
https://royalsocietypublishing.org/doi/10.1098/rsbl.2022.0464
The painting features even more bottles with paper wrappers or paper pluggers. Have a look yourself. #PaperHistory
As this room is full of papers, almanacs glued on the wall, old paper books lying around, a broadside glued on the window shutter, another broadside glued to the wall storing also letters or comments made on paper sheets, I sense this paper re-usage to protect liquids in bottles was a common thing? Historians of early modern apothecaries, do you know more? #histodons
3/3
Be sure to ask for Lando Calrissian, the administrator of this facility.
"Support academic access to automated cloud labs to improve reproducibility"
@PLOSBiology
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001919
🆕 #HorizonEU 2023 calls for proposals for #EU funding on #food, the #bioeconomy, #naturalresources, #agriculture & the #environment are now open!
Applicants can apply by 23 March and 12 April (depending on the call).
Over €890 million is available to fund innovative solutions that support:
🍎 #Healthy food
♻️ the #circulareconomy
🌍 the protection of #forests and #oceans
More information: https://europa.eu/!bHUYQP
At the NSF #ScienceFunding
"The success rate of proposals led by Asian scientists is about 20 percent below the overall rate — a disparity that has persisted for two decades and runs counter to the common narrative that Asian Americans dominate the sciences and engineering fields in the United States."
https://www.nytimes.com/2023/01/04/science/asian-scientists-nsf-funding.html
It's back!
AI in Drug Discovery 2022 - A Highly Opinionated Literature Review
https://practicalcheminformatics.blogspot.com/2023/01/ai-in-drug-discovery-2022-highly.html
RT @iaincheeseman@twitter.com
This is huge! American Cancer Society post-doc fellowships now open to all post-docs in the US (with appropriate visa) regardless of citizenship status. Fantastic move from this great organization in its support of trainees and science.
🐦🔗: https://twitter.com/iaincheeseman/status/1610797091873333248
In Japanese Buddhist cosmology Gakido is a parallel realm, said to be one of the four unhappy rebirths. In this barren & inhospitable wasteland, a #yokai spirit known as gaki lives in terrible torment & suffering. As punishment for sins in a past life they wander this awful place, eternally hungry & thirsty. Even if they eat they'll never feel satisfied. During obon some Buddhist traditions perform ceremonies to ease the suffering of gaki.
#folklore @folklore #japodon #JapaneseFolklore
In the aging research field, probably everyone knows this review: The Hallmarks of #Aging . Now there is a revised version with brand new hallmarks! 🌟👇
RT @gabbystern
Hi folks! In case you're not aware, @WHO has an informational YouTube channel: https://www.youtube.com/channel/UC07-dOwgza1IguKA86jqxNA I was just re-watching this October video of @mvankerkhove talking about the XBB recombinant, which was discussed at yesterday's presser as well: https://www.youtube.com/watch?v=pfwJdi1tuys
'Western health officials say privately that the checks on travellers have mostly been introduced to avert potential variants spreading undetected but that the current measures are not justified by any existing threat. One senior European official, who declined to be named, said it was a “political” decision, citing “governments that want to be seen as protecting their own people”.
https://www.ft.com/content/7623c671-6fc7-4e95-a177-594467a5d65e
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com