Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Interesting @EMBO@twitter.com podcast episode with @ChanZuckerberg@twitter.com’s head of science, Steve Quake.
In the interview's second half, Quake talks about #preprints, #OpenScience, open peer review, his experience posting preprints, and how they can accelerate science.
https://buff.ly/3Qr7zP7
Thiago Carvalho
boosted
Amazing new preprint from @KhademF Lab:
Paradoxical consequences of early hippocampal damage: greater atrophy is associated with better recall, working memory and visuospatial perception in developmental amnesia
Thiago Carvalho
boosted
RT @eggersnsf
Swiss universities are fighting to retain their position in Europe’s research and education landscape. Interesting piece in @swissinfo_en.
https://www.swissinfo.ch/eng/swiss-universities-rush-to-join-alliances-as-eu-talks-stall-/48220410
Thiago Carvalho
boosted
🚨 Please note! mstdn.science will likely **go down** for about 15 minutes at 11am GMT/UTC tomorrow (26 Jan). 🚨
This is to make some changes & allocate more space for all your amazing tooting! 🎺
Thanks to @happykhan for all is efforts in keeping mstdn.science, & to all of you for choosing mstdn.science as your instance! (And for your patience!) 🙏
Thiago Carvalho
boosted
Quick pastel after Warhol,
Lia Ferreira 2023
#uglydrawings in #softpastel on paper (mi-teintes, 32x41cm).
Gosh, I was in deprivation.
#portrait #quicksketch #quickdrawing #warhol #marilyn #marilynmonroe #drawing #pastelseco #retrato #desenhorapido #desenhosfeios #blonde #liaferreira
Thiago Carvalho
boosted
Come join our outstanding team of researchers at the Lunenfeld-Tanenbaum Research Institute! We are seeking applications for a Principal Investigator position in the broad area of Data Science. See link for more info or DM me. Please RT. apply.interfolio.com/118539
@SinaiHealth
"Using novel humanized IBC mouse models, we discovered that EGFR-targeted therapy remodels the IBC TME by increasing cytotoxic T cells and reducing immunosuppressive regulatory T cells and M2 macrophages. These changes were due to diminishing immunosuppressive chemokine expression regulated by transcription factor EGR1. We also showed that induction of an immunoactive IBC TME by an anti-EGFR antibody improved the antitumor efficacy of an anti–PD-L1 antibody."
#Immunology #Immunotherapy #EGFR #DrugDevelopment #MonoclonalAntibody
Thiago Carvalho
boosted
Glazed stoneware (15x16cm) by Madalena
Thiago Carvalho
boosted
ICYMI at the end of last year.
This was a really interesting episode of the #EMBOPodcast with Roberto di Lauro, a former group leader at the EMBL, professor at the University of Naples Federico II, and President of the Stazione Zoologica Anton Dohrn.
One aspect I really enjoyed was the discussion on the need for different types of research for different communities and applications - as well as some great discussions on the history of #MolecularBiology
(since this is essentially radio, one can also add: what a great voice).
https://www.embo.org/podcasts/we-should-know-more-this-is-our-main-job/
"One such example, the Mexican cavefish Astyanax mexicanus, has lost moderate-to-vigorous activity following cave colonization, reaching basal swim speeds ~3.7-fold slower than their river-dwelling counterpart. This change in behavior is accompanied by a marked shift in body composition, decreasing total muscle mass and increasing fat mass."
Thiago Carvalho
boosted
RT @ImmPRes_
did you notice that in the last release we added a feature to study protein families. For example, how about looking at the glycolytic proteins and how they change upon T cell activation in CD8s? #glycolysis #tcells #proteomics
Easily done in the heatmap section 😎
Thiago Carvalho
boosted
RT @GQuattrocolo@twitter.com
We are hiring! We have 2 open positions (1PhD and 1 postdoc). If you want to unravel the secrets of neuronal wiring, join the #QuattrocoloLab @KISNeuro@twitter.com. Info on Jobbnorge and lab website. Links in thread!
🐦🔗: https://twitter.com/GQuattrocolo/status/1618212222072918016
Thiago Carvalho
boosted
I love vivid words that Philip Ball peppers through his writing:
Indefatigable chronicler > Oliver Sacks.
Gloriously wrought device > the eye.
Fleshy cogitator > the brain.
The slings and arrows of experience > the nurture of nature/nurture.
Inspired, let's try a few out for ourselves (join me!). Hmmm. What am I thinking about today? It's still early, so ...
rationality elixer > coffee
Dusting away the horizontal fog > waking up
Battling the blinking cursor > writing
How about you?
Ball's book:
https://press.uchicago.edu/ucp/books/book/chicago/B/bo180760293.html
The physics big science wish list
"The future belongs to those who prepare for it, as scientists who petition federal agencies like NASA and the Department of Energy for research funds know all too well. The price of big-ticket instruments like a space telescope or particle accelerator can be as high as $10 billion.
And so this past June, the physics community began to consider what they want to do next, and why."
Thiago Carvalho
boosted
RT @jsauce7@twitter.com
5 open rank tenure-track/tenured faculty positions in any area of Biomedical Engineering @UVABME@twitter.com! Helping all of society through biomedical engineering research and education. https://uva.wd1.myworkdayjobs.com/en-US/UVAJobs/job/Charlottesville-VA/Open-Rank-Track-Faculty_R0043670
Thiago Carvalho
boosted
FL politicians, universities, DEI, transgender healthcare
In the last 3 weeks the Florida government has signaled an assault on universities:
1. Legislature issues sweeping request for employee names, correspondence & work related to DEI https://unfspinnaker.com/98971/news/florida-house-of-representatives-demands-dei-related-documents-from-state-institutions/
2. Governor's office requests information on transgender students seeking healthcare https://www.nbcnews.com/nbc-out/out-politics-and-policy/desantis-seeks-transgender-university-students-health-care-information-rcna66495
3. Governor requests spending data on all DEI efforts https://www.chronicle.com/article/fla-governor-asked-all-public-universities-for-spending-data-on-diversity-and-critical-race-theory
Its a frightening time in higher ed in Florida.
Thiago Carvalho
boosted
These are stories because insurance companies & Pharma run health care:
Who gets expensive new therapies? https://www.nytimes.com/2023/01/24/health/gene-therapies-cost-zolgensma.html?smid=nytcore-ios-share&referringSource=articleShare
Moderna to charge >$100/dose of publicly-funded vaccines https://www.thenation.com/article/economy/big-pharma-greed-knows-no-bounds/
More hospital layoffs https://www.beckershospitalreview.com/workforce/memorial-sloan-kettering-lays-off-337-employees.html?utm_campaign=bhr&utm_source=website&utm_content=featured-articles
"Following infection, hematopoietic stem and progenitor cells (HSPCs) support immunity by increasing the rate of innate immune cell production but the metabolic cues that guide this process are unknown. To address this question, we developed MetaFate, a method to trace the metabolic expression state and developmental fate of single cells in vivo."
#Preprint #Metabolism #InfetionImmunity #InnateImmunity #Immunology
https://www.biorxiv.org/content/10.1101/2023.01.24.525166v1?med=mas
Thiago Carvalho
boosted
Mandatário nacional do CHEGA causou perdas de centenas de milhares de euros a 20 pessoas
Empresa de Pedro Arroja rescindiu unilateralmente contratos com os clientes lesados. A CMVM não soube, o Banco de Portugal não tinha de saber, os clientes não foram informados e o economista nunca foi responsabilizado. O que falhou?
Por Ana Patrícia Silva: https://setentaequatro.pt/enfoque/mandatario-nacional-do-chega-causou-perdas-de-centenas-de-milhares-de-euros-20-pessoas
Regulatory challenges for AI in healthcare
"There is great excitement about the potential of AI to improve healthcare in a variety of ways, but such algorithms evolve rapidly and sometimes learn continuously. An approved AI algorithm can be locked but this has a disadvantage, as it may perform worse in sites outside of where it was trained, and a locked model that cannot learn will not improve."
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
