Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Well played

"Despite the multifactorial pathogenesis, available data show that long COVID is an organic post-acute infection syndrome (PAIS) with clear physiological dysfunction that is often not consistently apparent using standard medical diagnostic tests."

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00053-1/fulltext?s=09

"Recognizing that more is better is now an invalid assumption,1 the 2023 US Senate appropriations bill for FDA (included in S. 4661) and its report language encourage FDA to organize dose optimization clinical trials of marketed anticancer agents in an effort to reduce waste and/or toxicities of treatment without compromising efficacy."

https://ascopubs.org/doi/full/10.1200/JCO.22.02049?role=tab

'In the following review, we perform a synthesis of the different types of tumor antigens now being targeted with TCR-T cell therapy in the clinic and new promising antigens developed at the preclinical stage.'

#immunology #immunotherapy

https://www.science.org/doi/10.1126/sciadv.adf3700#.Y-1cGIGJPoE.linkedin

"According to Neruda’s family, a new forensics report conducted by a group of international experts has concluded that he was poisoned while already gravely ill—a victim, most probably, of the Chilean military he had politically opposed."

https://www.theatlantic.com/books/archive/2023/02/poet-pablo-neruda-poisoned-to-death-by-chilean-military/673078/

'A new study offers a glimpse of the future by looking to the past. Mosquitoes that transmit malaria in sub-Saharan Africa have moved to higher elevations by about 6.5 meters (roughly 21 feet) per year and away from the Equator by 4.7 kilometers (about three miles) per year over the past century, according to the study.'

#Malaria #climatechange

https://www.nytimes.com/2023/02/14/health/malaria-mosquitoes-climate-change.html?action=click&module=Well&pgtype=Homepage&section=Health

"We observed increased TGFβ-mediated induction of FoxP3+ cells in the presence of extracellular lactic acid, in a glycolysis-independent, acidity-dependent manner."

#immunology #Metabolism #Tregs

https://www.nature.com/articles/s41579-022-00837-3?utm_source=nrmicro_etoc&utm_medium=email&utm_campaign=toc_41579_21_3&utm_content=20230216

'What doctors eventually found inside the sample — inside the baby's respiratory tract — has fueled a shift in scientists' understanding of how pandemics begin and made them reconsider the way they search for new threatening viruses. It has made them realize there could be an easier, more efficient way to find viruses like SARS-CoV-2 before they evolve into a global nightmare.'

https://www.npr.org/sections/goatsandsoda/2023/02/15/1152892721/how-to-stop-pandemics