Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Population Genetic Considerations Regarding Evidence for Biased Mutation Rates in Arabidopsis thaliana https://doi.org/10.1093/molbev/msac275 #science #evolution #biology #genome #SciComm #evolgen_paper
Thiago Carvalho
boosted
Immunotherapy Physician Scientist Fellow
#ScienceJobs #job
Seattle #UnitedStatesUS #PostdoctoralFellow
https://jobrxiv.org/job/fred-hutchinson-cancer-center-27778-immunotherapy-physician-scientist-fellow/?feed_id=38648
Thiago Carvalho
boosted
This morning in 1971, a teletype operator at the National Emergency Warning Center in Cheyenne Mountain, Colorado, mistakenly transmitted a message via the Emergency Broadcast System notifying radio and TV stations nationwide the United States was under attack. http://conelrad.blogspot.com/2010/09/code-word-hatefulness-great-ebs-scare.html
Thiago Carvalho
boosted
Genome editing for the potential of curing diseases is taking off in directions that were not anticipated. I reviewed its recent and accelerated pace of progress
https://erictopol.substack.com/p/towards-genome-editing-cure-of-genetic
"In his 1821 book, “A Defense of Poetry,” Percy Shelley writes that an artist must learn to imagine what he knows. For many artists, the verdict of macular degeneration might have been disabling, or at least discouraging. For Jules, it was an invitation to imagine what he knew."
Details
"El problema de diseñar proteínas está resuelto. El reto es saber formular el problema que queremos resolver. Necesitamos una hipótesis molecular. Y para eso hay que comprender el origen de la enfermedad."
“Alongside the desacralisation and secularisation of public life,” Rovelli argues, “which passed from the hands of divine kings to those of citizens, came the desacralisation and secularisation of knowledge… law was not handed down once and for all but was instead questioned again and again.”
Thiago Carvalho
boosted
How Many Sirtuin Genes Are Out There? Evolution of Sirtuin Genes in Vertebrates With a Description of a New Family Member https://doi.org/10.1093/molbev/msad014 #science #evolution #biology #genome #SciComm #evolgen_paper
Thiago Carvalho
boosted
"The lack of appropriate neutralizing antibodies recognizing IL-2RG has made it difficult to thoroughly interrogate the role of γc cytokines in inflammatory and autoimmune disease settings. Here, we generated a γc cytokine receptor antibody, REGN7257, to determine whether γc cytokines might be targeted for T cell–mediated disease prevention and treatment."
Thiago Carvalho
boosted
"Ever since, he has been exploring organoid opportunities — in drug screening, disease modelling, clinical trial design and personalized medicine — in his academic lab, through biotechs and via scientific advisory boards. When he was offered the job as the head of Pharma Research & Early Development (pRED) at Roche, he jumped at the chance to take this organoid research to the next level."
"Together, our findings indicate that the AIM assay can be an effective tool for relative quantification of murine Ag-specific CD4+ T cells to protein vaccination, while demonstrating its limitations during conditions of acute and chronic infection."
“When the doctors switched off the life support machines, his mom climbed into bed beside him and I held my son’s hand as he passed away,” Puerta says. “This wasn’t an overdose because Daniel didn’t know what he was taking. He was intentionally deceived. He was poisoned.”
https://www.ft.com/content/bd1b1614-8407-4447-a0e3-3723368fbbf8
Thiago Carvalho
boosted
#Adipocyte #autophagy limits gut #inflammation by controlling #oxylipin and #interleukin IL-10
Katja Simon and coworkers
https://www.embopress.org/doi/10.15252/embj.2022112202
Thiago Carvalho
boosted
Blood Vessel Organoids for Development & Disease
Self-organizing capillary blood vessel #Organoid #EndothelialCell+#Pericyte (+Astrocyte for #BBB)
Transplant to gain vascular hierarchy
Organotypism Through Genetic Drivers
Dr. Josef Penninger lab Circ Res 2023
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.321768
Saint in Pamplona realizes what happened to Jake Barnes in "The Sun Also Rises"
Thiago Carvalho
boosted
#Immunology #cellimmunity @PLOSBiology LRRC15 is not a #SarsCoV2 entry receptor but can suppress spike-mediated entry . LRRC15 is also expressed in fibroblast cells, the cells that control lung fibrosis, a disease which causes damaged and scarred lung tissue. #COVID19 can lead to lung fibrosis, and the finding may have implications for #LongCovid.
📌https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001967
📌 https://journals.plos.org/plosbiology/issue
Thiago Carvalho
boosted
Postdoc (m/f/d) Tumor Biology - 23/02 @LeibnizFLI
#ScienceJobs #job
Jena #Germany #Researcher
https://jobrxiv.org/job/leibniz-institut-fur-alternsforschung-fritz-lipmann-institut-e-v-fli-27778-postdoc-m-f-d-tumor-biology-23-02/?feed_id=38600
Thiago Carvalho
boosted
#OtD 20 Feb 1988 20k people in Manchester marched against Margaret Thatcher's homophobic section 28 law, which made it illegal for public bodies to "promote" homosexuality, including teaching its "acceptability" in school
Thiago Carvalho
boosted
Notch signaling in development and homeostasis
In their 'Development at a glance' article and poster, Oren Gozlan and David Sprinzak provide a brief overview of the Notch signaling and function in development and homeostasis
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
