Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'After a father and daughter were diagnosed with bird flu, officials in Cambodia scrambled to test nearly a dozen of their contacts for infection the H5N1 virus, which has been causing mass die-offs of birds worldwide. The daughter, an 11-year-old, has died, but the World Health Organization said on Friday that 11 contacts have so far tested negative for the infection.'
Thiago Carvalho
boosted
Apparently there's going to be a new Three Musketeers movie with a Black D'Artagnan, and the usual suspects are doing the usual howling about wokeness and ahistoricity and so on. So here's your regular reminder the The Three Musketeers was written by a Black man. Dumas' father was the son of an enslaved African woman and a French Marquis (not a pretty story there), and he rose to become a hero of the French Revolutionary Wars and a General-in-Chief in the French army.
Thiago Carvalho
boosted
RT @NAR_Open
When translation elongation is impaired, the mRNA is uniformly destabilized by the RNA degradosome, while the concentration of mRNA is altered along the molecule https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad104/7058182
'The trafficking of monkeys, primarily long-tailed macaques, has become a growing concern in the region since Covid. In March 2020, China suspended the export of macaques, disrupting the supply of monkeys to laboratories in the US and creating a shortage that traffickers have sought to exploit, say animal rights experts.
Prior to the pandemic, trafficking of long-tailed macaques wasn’t a significant problem, said Wiek. “The price of long-tailed macaques on the illegal wildlife market was really low – $20 or $30 per piece. I wouldn’t call that a really sustainable kind of wildlife trade. But now the prices went up to five to 10 times more.”
"Here we report a murine model that expresses tumor-like levels of human APOBEC3B after Cre-mediated recombination. Animals appear to develop normally with full-body expression of APOBEC3B. However, adult males manifest infertility and older animals of both sexes show accelerated rates of tumorigenesis (mostly lymphomas or hepatocellular carcinomas)"
Thiago Carvalho
boosted
'Lingering Snow at Sanno' - Hasui Kawase, 1926.
#ukiyoe #JapaneseArt #Japan
Thiago Carvalho
boosted
Excess mortality among non #COVID19 surgical patients in 🇫🇷 French intensive & intermediate care units during #pandemic, nationwide study demonstrating considerable increase in surgical death risk during periods of high hospital exposure to #SARSCoV2 cases in ICU/IMCU beds. The majority of excess in‐hospital mortality resulted from inpatient deaths outside of #ICU/IMCU, suggesting limited access to critical care following surgery.
Free to read #FOAMcc on @ICM
https://rdcu.be/c6oHy
Thiago Carvalho
boosted
Postdoc for studying proteostasis, aging, biological clock and metabolism @LabZhu
Postdoc position for studying 12h clock regulation of phase separation dynamics, proteostasis, liver metabolism and aging at University of Pittsburgh
Thiago Carvalho
boosted
New preprint, by Victor Rossier with the group of Christophe Dessimoz (#UNIL and #SIB), introducing #Matreex, a new dynamic tool to scale-up the visualisation of gene families, and its application to showing loss of intraflagellar transport in a myxozoan
https://www.biorxiv.org/content/10.1101/2023.02.18.529053v1
#phylogeny #phylogenomics #bioinformatics #BigData #visualization #vizbi #myxozoan @dee_unil
1/thread
Thiago Carvalho
boosted
Thiago Carvalho
boosted
RT @Marc_Veld
Some #Immunology101:
A virus infection induces a strong T cell response. In the case of a virus; a type-1 response: involving Th1 cells and CD8 T cells. These cells are known to make the cytokine interferon-gamma (IFNg). They express activation markers, including PD-1.
'The N.I.H. said its scientists, some of whom had been collaborating for years with Moderna, had helped to design that sequence. Moderna also received nearly $10 billion in taxpayer funding to develop and test the vaccine, and to provide doses to the federal government. The company has sold roughly $36 billion worth of coronavirus vaccines worldwide.'
'How does amphibian MHC diversity fit in the landscape of vertebrate evolution? Minias et al. (2022) address this gap in the field of MHC evolution by focusing on the lesser described MHC class I in salamanders'
https://academic.oup.com/evolut/advance-article/doi/10.1093/evolut/qpad033/7051149?searchresult=1
Still the best parenting video ever made
'Derrotado frente a su hijo, el coronel Márquez volvió a la vida civil y vivió más de tres décadas como veterano de guerra, hasta que murió en 1937. García Márquez vivió con él, sus padres lo dejaron a su cuidado desde que era un bebé, y siempre contaba que uno de sus primeros recuerdos de infancia era dormir en un colchón junto a la cama del coronel.'
Regulatory CARTs #preprint
"The InsB-g7 CAR re-directed NOD Treg specificity such that insulin B 10-23-peptide stimulation enhanced suppressive function, measured via reduction of proliferation and IL-2 production by BDC2.5 T cells and CD80 and CD86 expression on dendritic cells. Co-transfer of InsB-g7 CAR Tregs prevented adoptive transfer diabetes by BDC2.5 T cells in immunodeficient NOD mice"
A reasonable proposition:
"Given the growth of withdrawals due to negative confirmatory trials and emerging evidence on the high spending associated with AA drugs, it is critical to balance early access against population-level exposure to cancer therapies with no benefit over standard of care."
In Aicardi-Goutières syndrome patient samples
"Using machine-learning approaches and differential gene expression we identified a drastic loss of transcription factor hypoxia induced factor 1 alpha (HIF-1a) expression and activity associated with features of a metabolic switch and mitochondrial stress in monocytes/dendritic cells."
Fits well with earlier work from Jocelyne's lab:
"Type I IFN sets the stringency of B cell repertoire selection in the bone marrow" (1999)
https://academic.oup.com/intimm/article/11/2/279/759572
and
"Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice" (2003)
https://www.sciencedirect.com/science/article/abs/pii/S0896841102001099
'The results provide evidence that elevated IFNα levels act directly on B cells to facilitate autoantibody production and further highlight the importance of IFN signaling as a potential therapeutic target in SLE.'
#immunology #interferon #Lupus #SLE #AutoAntibodies #Autoimmunity
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
