Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Our latest Issue is now complete! Check out the full Table of contents here: https://journals.biologists.com/jcs/issue/136/4
#cellbiology #research #science #sciencemastodon

Excited to present our work on measuring reproducibility of self-organized stem-cell assemblies in collab with @gregorscience at the #DevStem conference @ISTAustria today!

Many awesome talks and posters across the field lined up for this yearly Vienna conference!

A throwback piece on the Instituto Gulbenkian de Ciencia page about a small workshop that Miguel Soares & I organised on resistance and tolerance in 2010. This was back when most immunologists hearing "tolerance" would think only of T and B cell selection (and the occasional regulatory T cells). I'm a big fan of the small workshop, where everyone discusses unpublished work and feels free to speculate. We need more of these meetings.

https://gulbenkian.pt/ciencia/news/scientists-retreat-gave-away-new-era-fight-against-infections/

Eight storytelling tips from one of my favorite writers. Here's #1:

"Use the time of a total stranger in such a way that he or she will not feel the time was wasted."
#KurtVonnegut

https://www.themarginalian.org/2012/04/03/kurt-vonnegut-on-writing-stories/

#OtD 3 Mar 1976, in Vitoria-Gasteiz, Basque Country, Spanish police killed 5 workers and injured another 100 during a general strike. More information here: https://libcom.org/library/responses-questionnaire-submitted-txema-garc%C3%ADa-crespo-behalf-el-diario-miguel-amor%C3%B3s

A milestone for a young field:

Our community recommendations for single-cell proteomics are published OA in Nature Methods

https://nature.com/articles/s41592-023-01785-3

Preclinical study of anti-IL8 in endometriosis:

"We created a long-acting recycling antibody against IL-8 (AMY109) and evaluated its clinical potency. Because rodents do not produce IL-8 and do not experience menstruation, we analyzed the lesions in cynomolgus monkeys that spontaneously developed endometriosis and in a surgically induced endometriosis monkey model."
#Immunology #monoclonalantibodies #Endometriosis #inflammation

https://www.science.org/doi/10.1126/scitranslmed.abq5858

With a beautiful view of the Canals

'Yet it is still early days for AI drug discovery. There are a lot of AI companies making claims they can’t back up, says Prakash: “If somebody tells you they can perfectly predict which drug molecule can get through the gut or not get broken up by the liver, things like that, they probably also have land to sell you on Mars.”

https://www.technologyreview.com/2023/02/15/1067904/ai-automation-drug-development/?utm_campaign=site_visitor.unpaid.engagement&utm_medium=tr_social&utm_source=LinkedIn

Haruki Murakami on originality in art & literature (from "Novelist as a Vocation".

#books #writers #bookshelf #literature

Postdoctoral position in ecology, evolution, and genetics of Dictyostelium discoideum and its bacteria
The Queller-Strassmann group at Washington University in St. Louis has a postdoctoral position for a highly motivated individual interested in exploring this fascinating microbial system. We will begin reviewing applications by March 20 and will continue to accept them until the positions are filled. Start date is flexible.

Cis- and Trans-variations of Stearoyl-CoA Desaturase Provide New Insights into the Mechanisms of Diverged Pattern of Phenotypic Plasticity for Temperature Adaptation in Two Congeneric Oyster Species https://doi.org/10.1093/molbev/msad015 #science #evolution #biology #genome #SciComm #evolgen_paper

Tracing the origin of a group of ion channels important for neuronal communication sheds light on how these proteins evolved their role in the nervous system. https://elifesciences.org/digests/81613/making-new-with-old?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Rest in power #WayneShorter, brilliant #jazz saxophonist and composer in Miles Davis' Quintet and Weather Report. *NO ONE ELSE* wrote melodies with the mature, reflective poignancy of tunes like "Iris." Thanks for all the beauty, Wayne. 🙏https://youtu.be/bVtVobH3GDo

Had the chance to chat with Klaus Mäkelä, the 27 year-old conductor leading some of the world’s best orchestras

https://bachtrack.com/interview-klaus-makela-orchestre-de-paris-february-2023

Excited that our paper is now online! @veraksa @Ken_Moberg We show that the Hippo pathway and its new member, TIF1/TRIM ortholog Bon, control cell fate decisions in the Drosophila eye via a non-canonical transcriptional program. 50 days of free access link: https://authors.elsevier.com/c/1ggtb5Sx5gtwIP. #DevBio #Drosophila #HippoPathway #GeneRegulation #PaperThread 🧵 1/8