Thiago Carvalho @cyrilpedia@social.cleverlibre.org

'Using two independent real-world datasets from three different countries and an independent validation cohort based on the global, double-blind, placebo-controlled, phase 3 RECOURSE trial, we demonstrate that codon-specific KRAS mutations predict OS benefit for patients treated with the chemotherapeutic agent FTD/TPI in late-stage mCRC.'

#NatureMedicine #KRAS #PrecisionMedicine

https://www.nature.com/articles/s41591-023-02240-8#Sec7

'Election deniers won races for secretary of state—the post that oversees election administration—in Alabama, Indiana, South Dakota, and Wyoming. They make up most of the Republican freshman class in Congress. Even some of the losers came very close. Lake’s election-denying ticket mate, Abe Hamadeh, lost the Arizona attorney general’s race by 280 votes.'

https://www.theatlantic.com/politics/archive/2023/03/maricopa-county-arizona-election-officials-stop-the-steal/673235/

'Researchers on Monday announced promising results for a #tuberculosis #vaccine that can be freeze-dried and safely stored at higher temperatures for months, hailing a major breakthrough in the fight against one of humanity’s biggest killers and a major step towards overcoming one of the big barriers to vaccine distribution in poorer parts of the world.'

https://www.forbes.com/sites/roberthart/2023/03/06/breakthrough-for-tuberculosis-one-of-the-worlds-biggest-killers-as-new-vaccine-shows-promise-in-early-trials/?ss=health&sh=3ddaa04d293f

Getting ready to produce a few more episodes

https://www.embo.org/category/podcasts/

'Durante un año, Zhang ha buscado cualquier información sobre los tres bebés que nacieron tras los experimentos de Jiankui. “Es un secreto nacional”, resume la investigadora. No se sabe quiénes son, dónde están y, peor aún, si siguen vivas y sanas, aunque la científica aventura: “Asumimos que están bien”.

https://elpais.com/ciencia/2023-03-08/la-pregunta-mas-inquietante-de-la-ciencia-actual-sigue-sin-respuesta-estan-bien-los-primeros-bebes-modificados-geneticamente.html

The Falling Walls global call is open until May1st

"Falling Walls fosters discussion on research and innovation and promotes the latest scientific findings among a broad audience from all parts of society. We look forward to honouring the people who are finding solutions to these challenges at the Falling Walls Science Summit 2023."

https://falling-walls.com/global-call/

Molecular brain atlas

"An essential step towards understanding brain function is to obtain a parts list, i.e., a catalog of cell types, of the brain. Here, we report a comprehensive and high-resolution transcriptomic and spatial cell type atlas for the whole adult mouse brain."

#neuroscience #preprint

https://www.biorxiv.org/content/10.1101/2023.03.06.531121v1?utm_content=240482098&utm_medium=social&utm_source=linkedin&hss_channel=lcp-52151009

Opening in a moment at Museu Nacional de Arte Contemporânea do Chiado: “I-II-III-IV-V cinco décadas do Ar.Co - Centro de Arte e Comunicação Visual”

http://www.museuartecontemporanea.gov.pt/pt/programacao/2054

A privilege to work with @richardsever on this brief commentary piece on preprints, peer review & the special problems posed by medical/clinical manuscripts.
(it should be open access).

#Preprints #PeerReview #RefereedPreprints #scientificpublication

https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/19675/15075

Because blockchain technology has uses beyond crypto:

"Implementing Findable, Accessible, Interoperable, Reusable (FAIR) data solutions can be challenging. Semi-automated decentralised data sharing tools could support reserchers in making their data FAIR. Here the authors explore one possible solution."

https://network.febs.org/posts/a-revolution-of-data-in-the-life-sciences