Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
1/2
You may find this ☝️ article interesting in the context of Omran's "epidemiological transition" from infectious disease to so-called "chronic disease" that was posited to have occurred in the USA circa 1970.
Interestingly, the CDC has a webpage heavily influenced by this concept of "chronic disease", with absolutely no mention of infectious disease, and an exasperating conflation of the terms "cause" and "risk factor":
https://www.cdc.gov/chronicdisease/about/index.htm
'Let me start by laying my cards on the table. I’m the son of a missionary. My father’s parents were atheists and scientists. He, in adolescent rebellion, became a Christian; I, ditto, became an atheist.'
Thiago Carvalho
boosted
Referenced link: https://www.nature.com/articles/s41570-022-00456-9
Discuss on https://discu.eu/q/https://www.nature.com/articles/s41570-022-00456-9
Originally posted by Nature Portfolio / @NaturePortfolio: http://nitter.platypush.tech/NaturePortfolio/status/1637113903275450370#m
There is increasing demand for synthetic DNA. But, our ability to make DNA lags behind our ability to sequence it. A Review in @NatRevChem discusses commercialized DNA synthesis technologies in the pursuit of closing the DNA writing gap. 🔒 https://www.nature.com/articles/s41570-022-00456-9
"The World Health Organization rebuked Chinese officials on Friday for withholding research that may link Covid’s origin to wild animals, asking why the data had not been made available three years ago and why it is now missing."
Thiago Carvalho
boosted
Striking how benefits of Hybrid Closed-loop systems in Type 1 Diabetes are greater at night.
"Just let the system correct itself to perfection"
A good reference to have if you're working with nude mice:
"Here we present the genome assemblies for the NOD/SCID and BALB/c nude strains to overcome this short-coming for the future and improve our understanding of these models in the process."
#Preprint #Immunology
https://www.biorxiv.org/content/10.1101/2023.03.16.532783v1?med=mas
Based on data collected in Uganda between 2003 and 2018.
"This study suggests that male-targeted HIV programs to increase HIV suppression are critical to reduce incidence in women, close gender gaps in infection burden and improve men's health in Africa."
https://www.medrxiv.org/content/10.1101/2023.03.16.23287351v1
"Over and over, trials evaluating PD-1/PD-L1 inhibitors in advanced prostate cancer have missed the mark. The failures have led to questions as to why—and have prompted oncologists to conclude that new treatment strategies are needed."
#Immunology #immunotherapy #checkpointinhibitors #prostatecancer
Thiago Carvalho
boosted
That's a great question - the ability to attack bugs in biofilms was a big plus of phage therapy when we discussed it on the #EMBOPodcast precisely because traditional drugs were so bad at targeting them there https://www.embo.org/podcasts/the-enemy-of-my-enemy/
Thiago Carvalho
boosted
Thanks to @marcdionne for arranging an authentically grey & wet London experience.
It was a pleasure discussing the science behind the development of RNA vaccines with his students at Imperial.
Thiago Carvalho
boosted
we discussed this below paper from @vscooper on our journal back in 2019 (here is the link: https://onlinelibrary.wiley.com/doi/abs/10.1111/mec.15307), which was online just in time to motivate our setup, e.g. longer intervals of certain plant in the alternating environment, instead of alternating host each cycle
---
RT @EvolvedBiofilm
Story started by Chris Blake (MSc thesis) under the supervision of @MathildeNordga1, where we want…
https://twitter.com/EvolvedBiofilm/status/1637061757574299651
Thiago Carvalho
boosted
In this #house lives the #Blue.
There is no #deadend without an exit for it.
#street #streetphotograpjy #architecture #urban #urbanscape #sky #bluesky #photography #photodons
Hanuman inspired ceramics by @hunchbacksociety
#ceramics #handmade #ceramic #stoneware #handmade #ArtMastodon
"We tracked behavior of rewilded laboratory mice of three inbred strains in outdoor enclosures and examined contributions of behavior, including social associations, to immune phenotypes. We found that the more associated two individuals were, the more similar their immune phenotypes were. Social association was particularly predictive of similar memory T and B cell profiles and was more influential than sibling relationships or worm infection status."
https://www.biorxiv.org/content/10.1101/2023.03.15.532825v1?med=mas
This feels like it deserves a drum roll
"But to solidify the case for the hypothetical protoribosome, Yonath and her laboratory would have to build it."
'The World Health Organization said data from China suggesting Covid-19 arose from animals in Wuhan’s wet market should have been shared with the world three years ago, adding that the findings “do not provide a definitive answer” as to the origin of the virus.'
https://www.ft.com/content/939ed85a-2d07-4e11-a3a9-8781f802174f
Thiago Carvalho
boosted
Chef's kiss
"That is surely worth it just to preserve the lovely Icelandic word for computer: tölva, meaning number prophetess."
https://www.ft.com/content/262542a7-6616-4f4e-87b0-d0e39b27727f
Thiago Carvalho
boosted
'Recent studies have highlighted the value of using ancient genomes from different epochs, known as aDNA time series, to reconstruct the evolutionary history of immune disorders and past epidemics'
Thiago Carvalho
boosted
In a recent commentary in Nature Reviews Molecular Cell Biology, @Odedrechavi & Pavel Tomancak present some ideas on how to credit the work of co-authors on publications - essentially how to figure who did what, now that it is not unheard to see papers with three or more joint first authors (and senior authors as well).
https://www.nature.com/articles/s41580-023-00587-x
The issue matters, of course, for research assessment and career progression. Bernd Pulverer and Thomas Lemberger discussed some alternatives beyond simple authorial credit, making use of emerging #OpenScience tools. You can listen to our conversation at the link below.
#EMBOPodcast
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
