Thiago Carvalho @cyrilpedia@social.cleverlibre.org

We have a new memory-based framework for thinking about replay, showing that a surprisingly large range of the characteristics of wake and sleep replay can be explained by simple memory mechanisms. We are very eager to get your thoughts and feedback on this new model!

https://www.biorxiv.org/content/10.1101/2023.03.22.533833v1

IL-11 as a therapeutic target for lung #Fibrosis #Emphysema in #MarfanSyndrome

In Marfan🐭🫁, IL11-GFP reporter is active in #EndothelialCell #SmoothMuscleCell Fibroblast but not alveolar epithelia

Dr. Stuart A Cook & Wei Wen Lim lab ATVB 2023
https://www.ahajournals.org/doi/10.1161/ATVBAHA.122.318802

Also don't miss the story on IL-11 as mediator of Mafan #Aortopathy from Circ Res 2022

https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.320381

We had previously discovered TRIM34 as a novel inhibitor of HIV replication through an HIV-CRISPR Screen

https://doi.org/10.1371/journal.ppat.1008507

Similar to our previous findings for human TRIM34, we show that the antiviral of TRIM34 is dependent on its close paralog TRIM5

Our model is that TRIM34 and TRIM5 are able to interact and form a higher-order lattice that is able to inhibit the replication of some HIV viruses and primate lentiviruses more broadly

2/2

Wow!
https://www.biorxiv.org/content/10.1101/2023.03.21.533680v1

Human #microbiome research: Growing pains and future promises | PLOS Biology

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002053

The hummingbird as the Thermus aquaticus of RNA editing tools?

"We exogenously expressed different heterologous ADARs to reveal their distinct editing potential and identified two exceptionally active A-to-I editors: the hummingbird ADAR2, and primarily the mallard-duck ADAR1, whose core body temperature is 40–42°C."

https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010661

Op ed by Barney Graham

"We have entered a new era of ‌‌vaccine science, but can we ‌apply our extraordinary technical capabilities toward the goal of improving public health?"

#publichealth #vaccines

https://www.nytimes.com/2023/03/26/opinion/barney-graham-vaccine-science.html

"O Banco Central Europeu defende interesses e podemos ter a certeza que não são os das pessoas ou, como agora se diz tanto, os das famílias. Para quem tem dúvidas: reparem que ainda na semana passada, e enquanto anunciava o aumento das taxas de juro, Lagarde apelava ao fim dos apoios governamentais às famílias e às empresas."

https://www.publico.pt/2023/03/27/opiniao/opiniao/senhora-lagarde-cruella-2043912

Head of a child, 1939 #expressionism #paulklee https://www.wikiart.org/en/paul-klee/flower-stand-with-watering-can-and-bucket-1910

TFEB-dependent lysosome biogenesis is required for #senescence
by Bernadette Carroll and coworkers

Transcription factor #TFEB induces #lysosome proliferation in #senescent cells, counterbalancing reduced lysosomal efficiency and maintaining #autophagic capacity
https://www.embopress.org/doi/10.15252/embj.2022111241

A modular #transposon-based platform for dynamically rewiring gene regulatory networks in bacteria ➡️ https://www.embopress.org/doi/full/10.15252/msb.202211398
from J Collins, Broad Institute, MIT
#functionalgenomics #SynBio #SyntheticBiology #SystemsBiology #GeneRegulatoryNetwork

@NicoleCRust @MatteoCarandini @Iris @knutson_brain @albertcardona @schoppik @cyrilpedia
Nicole, I am not sure this is what you are loking for:
Perich MG, Rajan K (2020): Rethinking brain-wide interactions through multi-region ‘network of networks’ models. Current Opinion in Neurobiology 65:146–151.
Stringer C, Pachitariu M, Steinmetz N, Reddy CB, Carandini M, Harris KD (2019): Spontaneous behaviors drive multidimensional, brainwide activity. Science 364:255.

@NicoleCRust @MatteoCarandini @Iris @knutson_brain @schoppik @cyrilpedia

Only to add that present-day "AI" is built on artificial neural network architectures inspired by early neuroscience work in the 60's and 70's or so, mostly the visual system of the cat as far as I know.

We now know that biological neural networks are far more complex in both architecture and operation, and it is unclear to what extent such complexity serves the house-keeping operations of the cellular substrate (the neurons and glia) or is very much part of the implementation.

On that last point: not unlike Adrian Thompson's 2005 "An evolved circuit, intrinsic in silicon, entwined with physics" https://link.springer.com/chapter/10.1007/3-540-63173-9_61 where surprising and unexpected aspects of FPGA operation contribute significantly to the performance of circuits evolved with genetic algorithms.

#neuroscience #computing

Bioinformatics Analyst I @NazarianLabs

https://jobrxiv.org/job/childrens-national-hospital-27778-bioinformatics-analyst-i/?feed_id=41460

#ScienceJobs #job
Washington, D.C. #UnitedStatesUS #Bioinformatician
https://jobrxiv.org/job/childrens-national-hospital-27778-bioinformatics-analyst-i/?feed_id=41460